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protein coding gene - fim1 (SPBC1778.06c) - fimbrin

Gene summary

Standard name
fim1
Systematic ID
SPBC1778.06c
Product
fimbrin
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
O59945
ORFeome ID
46/46C02
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome II: 3106242..3108808 reverse strand

Annotation

Disease association

MONDO:0032917 - hearing loss, autosomal dominant 76

References:

MONDO:0010606 - hernia, anterior diaphragmatic

References:

MONDO:0018315 - X-linked osteoporosis with fractures

References:

GO biological process

GO:0044396 - actin cortical patch organization

References:

GO:0051017 - actin filament bundle assembly

References:

GO:0051639 - actin filament network formation

References:

GO:0044837 - actomyosin contractile ring organization

References:

GO:0072583 - clathrin-dependent endocytosis

References:

GO:0110009 - formin-nucleated actin cable organization

References:

GO cellular component

GO:0099079 - actin body

References:

GO:0030479 - actin cortical patch

References:

GO:0005884 - actin filament

References:

GO:0032432 - actin filament bundle

References:

GO:0032153 - cell division site

References:

GO:0031097 - medial cortex

References:

GO:0120106 - mitotic actomyosin contractile ring, distal actin filament layer

References:

GO:0070648 - formin-nucleated actin cable

References:

GO molecular function

GO:0051015 - actin filament binding

References:

GO:7770064 - actin-filament cross-linking activity

References:

GO:0005509 - calcium ion binding

References:

Modification

MOD:00046 - O-phospho-L-serine

References:

MOD:00047 - O-phospho-L-threonine

References:

MOD:01148 - ubiquitinylated lysine

References:

Multi-locus phenotype

FYPO:0002031 - abnormal actin cable morphology

References:

Genotypes:

FYPO:0000190 - abnormal actin cortical patch localization during vegetative growth

References:

Genotypes:

FYPO:0000164 - abnormal cell separation after cytokinesis

References:

Genotypes:

FYPO:0002023 - abnormal septum morphology during vegetative growth

References:

Genotypes:

FYPO:0005095 - abolished protein localization to chromatin at replication origin

References:

Genotypes:

FYPO:0003315 - actin cables absent from cell

References:

Genotypes:

FYPO:0006030 - actin cortical patches absent from cell

References:

Genotypes:

FYPO:0005853 - aggregated filamentous actin in cytoplasm

References:

Genotypes:

FYPO:0000422 - decreased endocytosis during vegetative growth

References:

Genotypes:

FYPO:0005628 - decreased rate of cell separation after cytokinesis

References:

Genotypes:

FYPO:0001355 - decreased vegetative cell population growth

References:

Genotypes:

FYPO:0000745 - delayed onset of actin cortical patch internalization

References:

Genotypes:

FYPO:0002021 - dispersed actin cortical patch localization during vegetative growth

References:

Genotypes:

FYPO:0001253 - elongated multinucleate multiseptate vegetative cell, single septa between nuclei

References:

Genotypes:

FYPO:0005096 - increased duration of protein localization to mitotic spindle pole body during anaphase

References:

Genotypes:

FYPO:0002262 - inviable after spore germination, multiple cell divisions, elongated cell

References:

Genotypes:

FYPO:0002302 - inviable after spore germination, multiple cell divisions, spheroid cell

References:

Genotypes:

FYPO:0004603 - inviable after spore germination, without cell division, elongated cell

References:

Genotypes:

FYPO:0002415 - inviable swollen vegetative cell with abnormal cell shape

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

FYPO:0002436 - misoriented actin cables

References:

Genotypes:

FYPO:0001390 - misoriented septum during vegetative growth

References:

Genotypes:

FYPO:0006082 - normal actin filament depolymerization

References:

Genotypes:

FYPO:0004257 - swollen multinucleate vegetative cell

References:

Genotypes:

FYPO:0002437 - thick actin cables

References:

Genotypes:

FYPO:0000647 - vegetative cell lysis

References:

Genotypes:

FYPO:0001495 - viable elongated multinucleate vegetative cell

References:

Genotypes:

FYPO:0001492 - viable elongated vegetative cell

References:

Genotypes:

Protein features

PBO:0111860 - calponin homology (CH) domain

PBO:0111761 - EF hand

Qualitative gene expression

PomGeneEx:0000011 - RNA level increased

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0005900 - abnormal actin filament-based movement

References:

Genotypes:

FYPO:0003338 - abnormal actomyosin contractile ring morphology

References:

Genotypes:

FYPO:0000164 - abnormal cell separation after cytokinesis

References:

Genotypes:

FYPO:0000032 - abnormal cytokinesis during vegetative growth

References:

Genotypes:

FYPO:0000196 - abnormal prospore formation

References:

Genotypes:

FYPO:0003066 - abnormal sporulation resulting in formation of ascus with fewer than four spores

References:

Genotypes:

FYPO:0001894 - abnormal sporulation resulting in formation of ascus with more or fewer than four spores

References:

Genotypes:

FYPO:0006025 - abolished actin filament binding

References:

Genotypes:

FYPO:0006026 - abolished actin filament bundle assembly

References:

Genotypes:

FYPO:0005095 - abolished protein localization to chromatin at replication origin

References:

Genotypes:

FYPO:0003315 - actin cables absent from cell

References:

Genotypes:

FYPO:0006027 - actin cables present in increased numbers

References:

Genotypes:

FYPO:0004964 - actin cortical patches present in decreased numbers

References:

Genotypes:

FYPO:0004972 - actin cortical patches present in increased numbers

References:

Genotypes:

FYPO:0001008 - actomyosin contractile ring absent

References:

Genotypes:

FYPO:0004562 - binucleate aseptate vegetative cell

References:

Genotypes:

FYPO:0002656 - decreased actin filament binding

References:

Genotypes:

FYPO:0005980 - decreased actin filament bundle assembly

References:

Genotypes:

FYPO:0006029 - decreased actin filament depolymerization

References:

Genotypes:

FYPO:0009053 - decreased cell population growth on glutamate nitrogen source

References:

Genotypes:

FYPO:0000684 - decreased cell population growth on glycerol carbon source

References:

Genotypes:

FYPO:0009091 - decreased cell population growth on lysine and proline nitrogen source

References:

Genotypes:

FYPO:0002924 - decreased cell population growth on maltose carbon source

References:

Genotypes:

FYPO:0001176 - decreased cell population growth on sucrose carbon source

References:

Genotypes:

FYPO:0004446 - decreased endocytosis during meiotic cell cycle

References:

Genotypes:

FYPO:0000422 - decreased endocytosis during vegetative growth

References:

Genotypes:

FYPO:0000470 - decreased mating type switching

References:

Genotypes:

FYPO:0006028 - decreased protein localization to actin cortical patch, with protein mislocalized to cytoplasm

References:

Genotypes:

FYPO:0003208 - decreased protein localization to cell tip, with protein distributed in plasma membrane or cortex

References:

Genotypes:

FYPO:0004444 - decreased protein localization to prospore membrane during meiosis II with protein mislocalized to plasma membrane

References:

Genotypes:

FYPO:0005628 - decreased rate of cell separation after cytokinesis

References:

Genotypes:

FYPO:0000581 - decreased spore germination frequency

References:

Genotypes:

FYPO:0000584 - decreased sporulation frequency

References:

Genotypes:

FYPO:0001355 - decreased vegetative cell population growth

References:

Genotypes:

FYPO:0000745 - delayed onset of actin cortical patch internalization

References:

Genotypes:

FYPO:0002021 - dispersed actin cortical patch localization during vegetative growth

References:

Genotypes:

FYPO:0002049 - elongated multinucleate aseptate vegetative cell

References:

Genotypes:

FYPO:0000133 - elongated multinucleate vegetative cell

References:

Genotypes:

FYPO:0005261 - increased cell population growth on galactose carbon source

References:

Genotypes:

FYPO:0009072 - increased cell population growth on lysine nitrogen source

References:

Genotypes:

FYPO:0005096 - increased duration of protein localization to mitotic spindle pole body during anaphase

References:

Genotypes:

FYPO:0006097 - increased protein localization to actin cable

References:

Genotypes:

FYPO:0006081 - increased protein localization to actin cortical patch

References:

Genotypes:

FYPO:0002025 - inviable elongated multinucleate vegetative cell with abnormal septum morphology

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

FYPO:0000245 - loss of viability in stationary phase

References:

Genotypes:

FYPO:0003988 - mislocalized actin cortical patches during vegetative growth

References:

Genotypes:

FYPO:0001369 - mislocalized actomyosin contractile ring

References:

Genotypes:

FYPO:0002436 - misoriented actin cables

References:

Genotypes:

FYPO:0001019 - monopolar actin cortical patch localization during vegetative growth

References:

Genotypes:

FYPO:0002487 - normal actin cable morphology

References:

Genotypes:

FYPO:0001294 - normal actin cortical patch localization

References:

Genotypes:

FYPO:0003717 - normal actin cytoskeleton morphology during vegetative growth

References:

Genotypes:

FYPO:0006024 - normal actin filament binding

References:

Genotypes:

FYPO:0004652 - normal actomyosin contractile ring morphology

References:

Genotypes:

FYPO:0000744 - normal protein localization to actin cortical patch

References:

Genotypes:

FYPO:0006876 - normal protein localization to cell cortex of cell tip

References:

Genotypes:

FYPO:0001357 - normal vegetative cell population growth

References:

Genotypes:

FYPO:0001120 - pear-shaped vegetative cell

References:

Genotypes:

FYPO:0006092 - polarized actin cortical patch localization during vegetative growth

References:

Genotypes:

FYPO:0009036 - resistance to benzamidine

References:

Genotypes:

FYPO:0009038 - resistance to egtazic acid

References:

Genotypes:

FYPO:0001583 - resistance to lithium

References:

Genotypes:

FYPO:0009085 - resistance to lithium chloride and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0009087 - resistance to magnesium chloride and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0000077 - resistance to rapamycin

References:

Genotypes:

FYPO:0005968 - resistance to sodium chloride

References:

Genotypes:

FYPO:0009040 - resistance to tea tree oil

References:

Genotypes:

FYPO:0007933 - sensitive to 2,2′-dipyridyl

References:

Genotypes:

FYPO:0001097 - sensitive to amitrole

References:

Genotypes:

FYPO:0000094 - sensitive to benomyl

References:

Genotypes:

FYPO:0001501 - sensitive to brefeldin A

References:

Genotypes:

FYPO:0000097 - sensitive to caffeine during vegetative growth

References:

Genotypes:

FYPO:0000104 - sensitive to cycloheximide

References:

Genotypes:

FYPO:0000842 - sensitive to ethanol during vegetative growth

References:

Genotypes:

FYPO:0007928 - sensitive to ethylenediaminetetraacetic acid

References:

Genotypes:

FYPO:0000785 - sensitive to formamide

References:

Genotypes:

FYPO:0000087 - sensitive to hydrogen peroxide

References:

Genotypes:

FYPO:0000088 - sensitive to hydroxyurea

References:

Genotypes:

FYPO:0000107 - sensitive to latrunculin A

References:

Genotypes:

FYPO:0006836 - sensitive to magnesium chloride

References:

Genotypes:

FYPO:0009088 - sensitive to magnesium chloride and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0000089 - sensitive to methyl methanesulfonate

References:

Genotypes:

FYPO:0001214 - sensitive to potassium chloride

References:

Genotypes:

FYPO:0007924 - sensitive to potassium chloride and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0000841 - sensitive to sodium dodecyl sulfate

References:

Genotypes:

FYPO:0000797 - sensitive to tert-butyl hydroperoxide

References:

Genotypes:

FYPO:0001457 - sensitive to tunicamycin

References:

Genotypes:

FYPO:0000115 - sensitive to valproic acid

References:

Genotypes:

FYPO:0003656 - sensitive to vanadate

References:

Genotypes:

FYPO:0000129 - spherical vegetative cell

References:

Genotypes:

FYPO:0000021 - spheroid vegetative cell

References:

Genotypes:

FYPO:0002437 - thick actin cables

References:

Genotypes:

FYPO:0000647 - vegetative cell lysis

References:

Genotypes:

FYPO:0002106 - viable stubby vegetative cell

References:

Genotypes:

FYPO:0001491 - viable vegetative cell

References:

Genotypes:

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

Protein features

IDNameInterPro nameDB name
PF00307CHCH_domPfam
cd21294CH_FIMB_rpt1CDD
cd21297CH_FIMB_rpt2CDD
cd21300CH_FIMB_rpt3CDD
cd21303CH_FIMB_rpt4CDD
PS00019ACTININ_1Actinin_actin-bd_CSPROSITE patterns
PS00020ACTININ_2Actinin_actin-bd_CSPROSITE patterns
PS50021CHCH_domPROSITE profiles
PS50222EF_HAND_2EF_hand_domPROSITE profiles
SM00033CHCH_domSMART
G3DSA:1.10.418.10:FF:000010CATH-FunFam
G3DSA:1.10.418.10:FF:000016CATH-FunFam
G3DSA:1.10.418.10:FF:000027CATH-FunFam
G3DSA:1.10.418.10:FF:000042CATH-FunFam
G3DSA:1.10.238.10CATH-Gene3D
G3DSA:1.10.418.10CH_dom_sfCATH-Gene3D
SSF47473EF-hand-dom_pairSUPERFAMILY
SSF47576CH_dom_sfSUPERFAMILY
PTHR19961Fimbrin/PlastinPANTHER

Orthologs

References / Literature

PMID:29996109 - Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe.
Swaffer MP et al. Cell Rep 2018 Jul 10;24(2):503-514
PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.
Halova L et al. Open Biol 2021 Apr;11(4):200405
PMID:28281664 - Genetic interactions and functional analyses of the fission yeast gsk3 and amk2 single and double mutants defective in TORC1-dependent processes.
Rallis C et al. Sci Rep 2017 Mar 10;7:44257
PMID:39012625 - Arp2/3-dependent endocytosis ensures Cdc42 oscillations by removing Pak1-mediated negative feedback.
Harrell MA et al. J Cell Biol 2024 Sep 02;223(10)
PMID:28914606 - Nanoscale architecture of the Schizosaccharomyces pombe contractile ring.
McDonald NA et al. Elife 2017 Sep 15;6
PMID:31509478 - The intrinsically disordered region of the cytokinetic F-BAR protein Cdc15 performs a unique essential function in maintenance of cytokinetic ring integrity.
Mangione MC et al. Mol Biol Cell 2019 Oct 15;30(22):2790-2801
PMID:21642440 - Actin filament bundling by fimbrin is important for endocytosis, cytokinesis, and polarization in fission yeast.
Skau CT et al. J Biol Chem 2011 Jul 29;286(30):26964-77
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:31495586 - Capping Protein Insulates Arp2/3-Assembled Actin Patches from Formins.
Billault-Chaumartin I et al. Curr Biol 2019 Oct 07;29(19):3165-3176.e6
PMID:34382996 - Ultrastructural plasma membrane asymmetries in tension and curvature promote yeast cell fusion.
Muriel O et al. J Cell Biol 2021 Oct 04;220(10)
PMID:16224022 - Counting cytokinesis proteins globally and locally in fission yeast.
Wu JQ et al. Science 2005 Oct 14;310(5746):310-4
PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.
Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963
PMID:30044717 - Roles of the fission yeast UNC-13/Munc13 protein Ync13 in late stages of cytokinesis.
Zhu YH et al. Mol Biol Cell 2018 Sep 15;29(19):2259-2279
PMID:11294907 - Roles of a fimbrin and an alpha-actinin-like protein in fission yeast cell polarization and cytokinesis.
Wu JQ et al. Mol Biol Cell 2001 Apr;12(4):1061-77
PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.
Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87
PMID:16866873 - Actin-capping protein is involved in controlling organization of actin cytoskeleton together with ADF/cofilin, profilin and F-actin crosslinking proteins in fission yeast.
Nakano K et al. Genes Cells 2006 Aug;11(8):893-905
PMID:27168121 - Discovery of genes involved in mitosis, cell division, cell wall integrity and chromosome segregation through construction of Schizosaccharomyces pombe deletion strains.
Chen JS et al. Yeast 2016 Sep;33(9):507-17
PMID:21832151 - Endocytosis is essential for dynamic translocation of a syntaxin 1 orthologue during fission yeast meiosis.
Kashiwazaki J et al. Mol Biol Cell 2011 Oct;22(19):3658-70
PMID:28218250 - Chromatin remodeller Fun30 Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.
Lee J et al. Nat Commun 2017 Feb 20;8:14527
PMID:28282023 - Competition between Tropomyosin, Fimbrin, and ADF/Cofilin drives their sorting to distinct actin filament networks.
Christensen JR et al. Elife 2017 Mar 10;6
PMID:20705466 - Fimbrin and tropomyosin competition regulates endocytosis and cytokinesis kinetics in fission yeast.
Skau CT et al. Curr Biol 2010 Aug 24;20(16):1415-22
PMID:37531259 - Membrane binding of endocytic myosin-1s is inhibited by a class of ankyrin repeat proteins.
Willet AH et al. Mol Biol Cell 2023 Oct 01;34(11):br17
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:26187949 - Evolutionarily conserved sites in yeast tropomyosin function in cell polarity, transport and contractile ring formation.
Cranz-Mileva S et al. Biol Open 2015 Jul 17;4(8):1040-51
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:20587778 - Quantitative analysis of the mechanism of endocytic actin patch assembly and disassembly in fission yeast.
Sirotkin V et al. Mol Biol Cell 2010 Aug 15;21(16):2894-904
PMID:20705471 - Differential regulation of unconventional fission yeast myosins via the actin track.
Clayton JE et al. Curr Biol 2010 Aug 24;20(16):1423-31
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:22119525 - SIN-inhibitory phosphatase complex promotes Cdc11p dephosphorylation and propagates SIN asymmetry in fission yeast.
Singh NS et al. Curr Biol 2011 Dec 06;21(23):1968-78
PMID:23770677 - In vitro contraction of cytokinetic ring depends on myosin II but not on actin dynamics.
Mishra M et al. Nat Cell Biol 2013 Jul;15(7):853-9
PMID:19713940 - Fission yeast IQGAP arranges actin filaments into the cytokinetic contractile ring.
Takaine M et al. EMBO J 2009 Oct 21;28(20):3117-31
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.
Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
PMID:15274920 - Structure of the actin crosslinking core of fimbrin.
Klein MG et al. Structure 2004 Jun;12(6):999-1013
PMID:29852001 - New insights into donor directionality of mating-type switching in Schizosaccharomyces pombe.
Maki T et al. PLoS Genet 2018 May;14(5):e1007424
PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.
Strachan J et al. J Cell Sci 2023 Dec 01;136(23)
GO_REF:0000002 - Comments
PMID:34250083 - Barcode sequencing and a high-throughput assay for chronological lifespan uncover ageing-associated genes in fission yeast.
Romila CA et al. Microb Cell 2021 Jul 05;8(7):146-160
PB_REF:0000003 - Disease Association Curation
PMID:26124291 - A stable microtubule array drives fission yeast polarity reestablishment upon quiescence exit.
Laporte D et al. J Cell Biol 2015 Jul 06;210(1):99-113
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:11694585 - Interactions among a fimbrin, a capping protein, and an actin-depolymerizing factor in organization of the fission yeast actin cytoskeleton.
Nakano K et al. Mol Biol Cell 2001 Nov;12(11):3515-26
PMID:15743909 - Profilin-mediated competition between capping protein and formin Cdc12p during cytokinesis in fission yeast.
Kovar DR et al. Mol Biol Cell 2005 May;16(5):2313-24
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:24115772 - SIN-dependent phosphoinhibition of formin multimerization controls fission yeast cytokinesis.
Bohnert KA et al. Genes Dev 2013 Oct 01;27(19):2164-77
PMID:16537923 - Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.
Todd BL et al. Mol Cell Biol 2006 Apr;26(7):2817-31
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:22740629 - α-Actinin and fimbrin cooperate with myosin II to organize actomyosin bundles during contractile-ring assembly.
Laporte D et al. Mol Biol Cell 2012 Aug;23(16):3094-110
PMID:26412298 - A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.
Beckley JR et al. Mol Cell Proteomics 2015 Dec;14(12):3132-41
PMID:27918601 - Identifying genes required for respiratory growth of fission yeast.
Malecki M et al. Wellcome Open Res 2016;1:12