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protein coding gene - pgr1 (SPBC17A3.07) - mitochondrial glutathione reductase Pgr1 OR mitochondrial glutathione reductase Pgr1

Gene summary

Standard name
pgr1
Systematic ID
SPBC17A3.07
Product
mitochondrial glutathione reductase Pgr1 OR mitochondrial glutathione reductase Pgr1
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
pi039
UniProt ID
P78965
ORFeome ID
33/33A07
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome II: 1414254..1416156 forward strand

Annotation

Disease association

MONDO:0019531 - hemolytic anemia due to glutathione reductase deficiency

References:

GO biological process

GO:0045454 - cell redox homeostasis

References:

GO:0098869 - cellular oxidant detoxification

References:

GO:0034599 - cellular response to oxidative stress

References:

GO:0006749 - glutathione metabolic process

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GO:0070301 - cellular response to hydrogen peroxide

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GO cellular component

GO:0005737 - cytoplasm

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GO:0005829 - cytosol

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GO:0005739 - mitochondrion

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GO molecular function

GO:0050660 - flavin adenine dinucleotide binding

References:

GO:0004362 - glutathione-disulfide reductase (NADPH) activity

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Modification

MOD:00689 - disulfide crosslinked residues

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MOD:01148 - ubiquitinylated lysine

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Multi-locus phenotype

FYPO:0001355 - decreased vegetative cell population growth

References:

Genotypes:

FYPO:0001753 - normal anaerobic cell population growth

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Genotypes:

FYPO:0000087 - sensitive to hydrogen peroxide

References:

Genotypes:

FYPO:0002060 - viable vegetative cell population

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Genotypes:

Qualitative gene expression

PomGeneEx:0000011 - RNA level increased

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PomGeneEx:0000013 - RNA level unchanged

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PomGeneEx:0000014 - RNA present

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Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0001430 - abnormal mitotic cell cycle arrest with unreplicated DNA

References:

Genotypes:

FYPO:0010034 - abolished nuclear pore clustering during cellular response to hydroxyurea

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Genotypes:

FYPO:0002008 - decreased aconitate hydratase activity

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Genotypes:

FYPO:0003238 - decreased anaerobic cell population growth

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Genotypes:

FYPO:0001570 - decreased cellular glutathione level during vegetative growth

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Genotypes:

FYPO:0000342 - decreased cellular respiration

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Genotypes:

FYPO:0002009 - decreased oxygen consumption during vegetative growth

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Genotypes:

FYPO:0003949 - decreased sulfite reductase activity

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Genotypes:

FYPO:0001355 - decreased vegetative cell population growth

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Genotypes:

FYPO:0001111 - increased cellular glutathione disulfide level

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Genotypes:

FYPO:0002006 - increased cellular iron level

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Genotypes:

FYPO:0001108 - increased glutathione-disulfide reductase activity

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Genotypes:

FYPO:0001110 - inviable after spore germination, multiple cell divisions, normal morphology

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Genotypes:

FYPO:0002111 - inviable tapered vegetative cell

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Genotypes:

FYPO:0002061 - inviable vegetative cell population

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Genotypes:

FYPO:0001753 - normal anaerobic cell population growth

References:

Genotypes:

FYPO:0000962 - normal growth on hydrogen peroxide

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Genotypes:

FYPO:0003994 - normal succinate dehydrogenase activity

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Genotypes:

FYPO:0001109 - resistance to menadione

References:

Genotypes:

FYPO:0000087 - sensitive to hydrogen peroxide

References:

Genotypes:

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

Taxonomic conservation

PBO:0011067 - conserved in bacteria

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF02852Pyr_redox_dimPyr_nucl-diS_OxRdtase_dimerPfam
PF07992Pyr_redox_2FAD/NAD-binding_domPfam
PS00076PYRIDINE_REDOX_1Pyr_OxRdtase_I_ASPROSITE patterns
PR00368FADPNRPRINTS
PR00411PNDRDTASEIPRINTS
G3DSA:3.30.390.30:FF:000003CATH-FunFam
G3DSA:3.50.50.60:FF:000109CATH-FunFam
G3DSA:3.30.390.30FAD/NAD-linked_Rdtase_dimer_sfCATH-Gene3D
G3DSA:3.50.50.60FAD/NAD-bd_sfCATH-Gene3D
SSF51905FAD/NAD-bd_sfSUPERFAMILY
SSF55424FAD/NAD-linked_Rdtase_dimer_sfSUPERFAMILY
PTHR42737GSHR/TRXR-likePANTHER
PIRSF000350Mercury_reductase_MerAPyr_nuc-diS_OxRdtasePIRSF
NF004776gorANCBIFAM
TIGR01421gluta_reduc_1Glutathione_Rdtase_euk/bacNCBIFAM

Orthologs

References / Literature

PMID:36408920 - UniProt: the Universal Protein Knowledgebase in 2023.
UniProt Consortium Nucleic Acids Res 2023 Jan 06;51(D1):D523-D531
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:25375137 - Systematic analysis of the role of RNA-binding proteins in the regulation of RNA stability.
Hasan A et al. PLoS Genet 2014 Nov;10(11):e1004684
PMID:41259369 - Hydroxyurea induces an oxidative stress response that triggers ER expansion and cytoplasmic protein aggregation.
Sánchez-Molina A et al. PLoS Biol 2025 Nov 19;23(11):e3003493
PMID:9287302 - Isolation, expression, and regulation of the pgr1(+) gene encoding glutathione reductase absolutely required for the growth of Schizosaccharomyces pombe.
Lee J et al. J Biol Chem 1997 Sep 12;272(37):23042-9
PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.
Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:16537923 - Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.
Todd BL et al. Mol Cell Biol 2006 Apr;26(7):2817-31
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:16950927 - Glutathione reductase and a mitochondrial thioredoxin play overlapping roles in maintaining iron-sulfur enzymes in fission yeast.
Song JY et al. Eukaryot Cell 2006 Nov;5(11):1857-65
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:26412298 - A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.
Beckley JR et al. Mol Cell Proteomics 2015 Dec;14(12):3132-41
PMID:28640807 - Lack of a peroxiredoxin suppresses the lethality of cells devoid of electron donors by channelling electrons to oxidized ribonucleotide reductase.
Boronat S et al. PLoS Genet 2017 Jun;13(6):e1006858
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:30824696 - Systematic analysis reveals the prevalence and principles of bypassable gene essentiality.
Li J et al. Nat Commun 2019 Mar 01;10(1):1002
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7