PomBase home

protein coding gene - acr1 (SPBC17D1.04) - RNA polymerase I upstream activation factor complex subunit Acr1

Gene summary

Standard name
acr1
Systematic ID
SPBC17D1.04
Product
RNA polymerase I upstream activation factor complex subunit Acr1
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
Q10204
ORFeome ID
43/43B05
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome II: 3333546..3335085 forward strand

Annotation

GO biological process

GO:0023052 - signaling

References:

GO:0006360 - transcription by RNA polymerase I

References:

GO:0006409 - tRNA export from nucleus

References:

GO cellular component

GO:0005829 - cytosol

References:

GO:0005730 - nucleolus

References:

GO:0000500 - RNA polymerase I upstream activating factor complex

References:

GO molecular function

GO:0001181 - RNA polymerase I general transcription initiation factor activity

References:

Qualitative gene expression

PomGeneEx:0000019 - protein level decreased

References:

PomGeneEx:0000027 - ribosomal density decreased

References:

Quantitative gene expression

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0003738 - abnormal mitotic cell cycle arrest with condensed chromosomes

References:

Genotypes:

FYPO:0004506 - abnormal nucleolar chromatin organization resulting in peripheral chromatin distribution

References:

Genotypes:

FYPO:0003829 - abolished mitotic spindle elongation

References:

Genotypes:

FYPO:0002391 - decreased protein localization to chromatin at rDNA

References:

Genotypes:

FYPO:0001514 - decreased protein localization to nucleus during vegetative growth

References:

Genotypes:

FYPO:0002170 - inviable after spore germination, multiple cell divisions, branched, elongated cell

References:

Genotypes:

FYPO:0001489 - inviable vegetative cell

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

FYPO:0000228 - lagging mitotic chromosomes

References:

Genotypes:

FYPO:0002901 - normal protein localization to kinetochore during vegetative growth

References:

Genotypes:

FYPO:0000732 - short bipolar mitotic spindle

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011063 - conserved in fungi only

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
CoilCoilCOILS
mobidb-lite-Disorderdisorder_predictionMOBIDB-Disorder

Orthologs

References / Literature

GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
GO_REF:0000111 - Gene Ontology annotations Inferred by Curator (IC) using at least one Inferred by Sequence Similarity (ISS) annotation to support the inference
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.
Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:24713849 - Post-transcriptional regulation of meiotic genes by a nuclear RNA silencing complex.
Egan ED et al. RNA 2014 Jun;20(6):867-81
PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.
Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399
GO_REF:0000051 - S. pombe keyword mapping
PMID:18362178 - Dissection of the essential steps for condensin accumulation at kinetochores and rDNAs during fission yeast mitosis.
Nakazawa N et al. J Cell Biol 2008 Mar 24;180(6):1115-31
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7