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protein coding gene - npg1 (SPBC17D1.07c) - GTPase regulator Rng2-like

Gene summary

Standard name
npg1
Systematic ID
SPBC17D1.07c
Product
GTPase regulator Rng2-like
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
Q10201
ORFeome ID
48/48A02
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome II: 3340660..3344365 reverse strand

Annotation

GO biological process

GO:0032120 - ascospore-type prospore membrane formation

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GO cellular component

GO:0005634 - nucleus

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GO:0005628 - prospore membrane

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GO:0070057 - prospore membrane spindle pole body attachment site

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GO molecular function

GO:0051015 - actin filament binding

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GO:0005509 - calcium ion binding

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GO:0005516 - calmodulin binding

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GO:0005096 - GTPase activator activity

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Modification

MOD:00046 - O-phospho-L-serine

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Protein features

PBO:0111860 - calponin homology (CH) domain

PBO:0111829 - IQ domain

Qualitative gene expression

PomGeneEx:0000018 - protein level increased

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PomGeneEx:0000021 - protein present

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PomGeneEx:0000011 - RNA level increased

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Quantitative gene expression

PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0001914 - abnormal prospore membrane formation

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Genotypes:

FYPO:0003549 - abnormal protein localization during meiosis

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Genotypes:

FYPO:0000121 - abnormal sporulation

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Genotypes:

FYPO:0003066 - abnormal sporulation resulting in formation of ascus with fewer than four spores

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Genotypes:

FYPO:0006010 - abolished shmoo contact with partner cell

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Genotypes:

FYPO:0003789 - decreased frequency of meiosis II

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Genotypes:

FYPO:0000581 - decreased spore germination frequency

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Genotypes:

FYPO:0004806 - incomplete cell wall disassembly at cell fusion site

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Genotypes:

FYPO:0002150 - inviable spore population

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Genotypes:

FYPO:0003790 - normal protein localization during meiosis

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Genotypes:

FYPO:0000764 - resistance to cycloheximide

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Genotypes:

FYPO:0002693 - resistance to diamide

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Genotypes:

FYPO:0009038 - resistance to egtazic acid

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Genotypes:

FYPO:0001453 - resistance to ethanol

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Genotypes:

FYPO:0002578 - resistance to hydroxyurea

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Genotypes:

FYPO:0009043 - resistance to potassium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0003383 - resistance to tert-butyl hydroperoxide

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Genotypes:

FYPO:0000830 - resistance to vanadate

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Genotypes:

FYPO:0009086 - sensitive to lithium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0001492 - viable elongated vegetative cell

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Genotypes:

FYPO:0002060 - viable vegetative cell population

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Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

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Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0009798 - faster evolving duplicate

Warnings

PBO:0000070 - gene structure updated

References:

Protein features

IDNameInterPro nameDB name
PF00307CHCH_domPfam
cd21206CH_IQGAPCDD
PS50021CHCH_domPROSITE profiles
SM00033CHCH_domSMART
G3DSA:1.10.418.10CH_dom_sfCATH-Gene3D
SSF47576CH_dom_sfSUPERFAMILY
PTHR14149PANTHER

Orthologs

References / Literature

GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:12161753 - The transcriptional program of meiosis and sporulation in fission yeast.
Mata J et al. Nat Genet 2002 Sep;32(1):143-7
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:25146394 - The meiosis-specific nuclear passenger protein is required for proper assembly of forespore membrane in fission yeast.
Takaine M et al. J Cell Sci 2014 Oct 15;127(Pt 20):4429-42
PMID:28410370 - A systematic screen for morphological abnormalities during fission yeast sexual reproduction identifies a mechanism of actin aster formation for cell fusion.
Dudin O et al. PLoS Genet 2017 Apr;13(4):e1006721
PMID:29259000 - Genes Important for Schizosaccharomyces pombe Meiosis Identified Through a Functional Genomics Screen.
Blyth J et al. Genetics 2018 Feb;208(2):589-603
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
GO_REF:0000050 - Manual transfer of GO annotation data to genes by curator judgment of sequence model