protein coding gene - nto1 (SPBC17D11.04c) - histone acetyltransferase complex PHD finger subunit Nto1

Gene summary

Standard name

nto1

Systematic ID

SPBC17D11.04c

Product

histone acetyltransferase complex PHD finger subunit Nto1

Organism

Schizosaccharomyces pombe (fission yeast)

UniProt ID

O74759

ORFeome ID

38/38B12

Characterisation status

biological role inferred

Feature type

mRNA gene

Genomic location

chromosome II: 3310435..3312909 reverse strand

Annotation

Protein features

Orthologs

• BRD1 (HGNC:1102) Homo sapiens
• BRPF1 (HGNC:14255) Homo sapiens
• BRPF3 (HGNC:14256) Homo sapiens
• nto1 (SJAG_02629) Schizosaccharomyces japonicus
• NTO1 (YPR031W) Saccharomyces cerevisiae

References / Literature

PMID:22184112 - Histone H3 lysine 14 acetylation is required for activation of a DNA damage checkpoint in fission yeast.

Wang Y et al. J Biol Chem 2012 Feb 03;287(6):4386-93

PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36

PMID:26988418 - The proper connection between shelterin components is required for telomeric heterochromatin assembly.

Wang J et al. Genes Dev 2016 Apr 01;30(7):827-39

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.

Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7

PMID:18818364 - Conservation and rewiring of functional modules revealed by an epistasis map in fission yeast.

Roguev A et al. Science 2008 Oct 17;322(5900):405-10

PMID:33260998 - High-Throughput Flow Cytometry Combined with Genetic Analysis Brings New Insights into the Understanding of Chromatin Regulation of Cellular Quiescence.

Zahedi Y et al. Int J Mol Sci 2020 Nov 27;21(23)

PMID:32269268 - Abo1 is required for the H3K9me2 to H3K9me3 transition in heterochromatin.

Dong W et al. Sci Rep 2020 Apr 08;10(1):6055

PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs

PMID:21289066 - Elimination of a specific histone H3K14 acetyltransferase complex bypasses the RNAi pathway to regulate pericentric heterochromatin functions.

Reddy BD et al. Genes Dev 2011 Feb 01;25(3):214-9

PMID:25774602 - Rapid epigenetic adaptation to uncontrolled heterochromatin spreading.

Wang J et al. Elife 2015 Mar 16;4

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.

Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.

Rodríguez-López M et al. Elife 2023 Oct 03;12

GO_REF:0000033 - Annotation inferences using phylogenetic trees

PMID:24909977 - A histone H3K36 chromatin switch coordinates DNA double-strand break repair pathway choice.

Pai CC et al. Nat Commun 2014 Jun 09;5:4091