protein coding gene - nak1 (SPBC17F3.02) - PAK-related GC kinase Nak1

Gene summary

Standard name

nak1

Systematic ID

SPBC17F3.02

Product

PAK-related GC kinase Nak1

Organism

Schizosaccharomyces pombe (fission yeast)

Synonyms

orb3, mor4

UniProt ID

O75011

ORFeome ID

39/39F06

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome II: 2482067..2484425 reverse strand

Annotation

Protein features

Orthologs

• STK24 (HGNC:11403) Homo sapiens
• STK25 (HGNC:11404) Homo sapiens
• STK26 (HGNC:18174) Homo sapiens
• nak1 (SJAG_04461) Schizosaccharomyces japonicus
• KIC1 (YHR102W) Saccharomyces cerevisiae

References / Literature

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.

Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7

PMID:38442865 - The fission yeast NDR kinase Orb6 and its signalling pathway MOR regulate cytoplasmic microtubule organization during the cell cycle.

Kume K et al. Open Biol 2024 Mar;14(3):230440

GO_REF:0000033 - Annotation inferences using phylogenetic trees

PMID:17317928 - A method for Pmo25-associated kinase assay in fission yeast: the activity is dependent on two gC kinases Nak1 and Sid1.

Kume K et al. Biosci Biotechnol Biochem 2007 Feb;71(2):615-7

PMID:12427731 - Nak1, an essential germinal center (GC) kinase regulates cell morphology and growth in Schizosaccharomyces pombe.

Huang TY et al. J Biol Chem 2003 Jan 10;278(2):991-7

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:29996109 - Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe.

Swaffer MP et al. Cell Rep 2018 Jul 10;24(2):503-514

PMID:15731009 - Ste20/GCK kinase Nak1/Orb3 polarizes the actin cytoskeleton in fission yeast during the cell cycle.

Leonhard K et al. J Cell Sci 2005 Mar 01;118(Pt 5):1033-44

PMID:20826805 - Fission yeast germinal center (GC) kinase Ppk11 interacts with Pmo25 and plays an auxiliary role in concert with the morphogenesis Orb6 network (MOR) in cell morphogenesis.

Goshima T et al. J Biol Chem 2010 Nov 05;285(45):35196-205

PMID:20805322 - The mitosis-to-interphase transition is coordinated by cross talk between the SIN and MOR pathways in Schizosaccharomyces pombe.

Ray S et al. J Cell Biol 2010 Sep 06;190(5):793-805

PMID:19547744 - Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.

Beltrao P et al. PLoS Biol 2009 Jun 16;7(6):e1000134

PMID:8187760 - Genetic analysis of cell morphogenesis in fission yeast--a role for casein kinase II in the establishment of polarized growth.

Snell V et al. EMBO J 1994 May 01;13(9):2066-74

PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.

Halova L et al. Open Biol 2021 Apr;11(4):200405

PMID:24972934 - Cross talk between NDR kinase pathways coordinates cytokinesis with cell separation in Schizosaccharomyces pombe.

Gupta S et al. Eukaryot Cell 2014 Aug;13(8):1104-12

PMID:19808887 - Ste20-kinase-dependent TEDS-site phosphorylation modulates the dynamic localisation and endocytic function of the fission yeast class I myosin, Myo1.

Attanapola SL et al. J Cell Sci 2009 Nov 01;122(Pt 21):3856-61

PMID:39476757 - Characterization of Ksg1 protein kinase-dependent phosphoproteome in the fission yeast S. pombe.

Cipak L et al. Biochem Biophys Res Commun 2024 Oct 25;736:150895

PMID:15821139 - Systematic deletion analysis of fission yeast protein kinases.

Bimbó A et al. Eukaryot Cell 2005 Apr;4(4):799-813

PMID:23615447 - Compartmentalized nodes control mitotic entry signaling in fission yeast.

Deng L et al. Mol Biol Cell 2013 Jun;24(12):1872-81

PMID:15615784 - Nak1 interacts with Hob1 and Wsp1 to regulate cell growth and polarity in Schizosaccharomyces pombe.

Huang TY et al. J Cell Sci 2005 Jan 01;118(Pt 1):199-210

GO_REF:0000051 - S. pombe keyword mapping

PMID:16096637 - Fission yeast MO25 protein is localized at SPB and septum and is essential for cell morphogenesis.

Kanai M et al. EMBO J 2005 Sep 07;24(17):3012-25

PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.

Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87

PMID:21712547 - Mitotic substrates of the kinase aurora with roles in chromatin regulation identified through quantitative phosphoproteomics of fission yeast.

Koch A et al. Sci Signal 2011 Jun 28;4(179):rs6

PMID:19646873 - The conserved NDR kinase Orb6 controls polarized cell growth by spatial regulation of the small GTPase Cdc42.

Das M et al. Curr Biol 2009 Aug 11;19(15):1314-9

PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.

Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105

PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.

Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:23462181 - Crosstalk between casein kinase II and Ste20-related kinase Nak1.

Cipak L et al. Cell Cycle 2013 Mar 15;12(6):884-8

PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.

Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:27984744 - Survival in Quiescence Requires the Euchromatic Deployment of Clr4/SUV39H by Argonaute-Associated Small RNAs.

Joh RI et al. Mol Cell 2016 Dec 15;64(6):1088-1101

PMID:23649273 - Fission yeast leucine-rich repeat protein Lrp1 is essential for cell morphogenesis as a component of the morphogenesis Orb6 network (MOR).

Kume K et al. Biosci Biotechnol Biochem 2013;77(5):1086-91

PMID:8522609 - Fission yeast cell morphogenesis: identification of new genes and analysis of their role during the cell cycle.

Verde F et al. J Cell Biol 1995 Dec;131(6 Pt 1):1529-38

PMID:23394829 - Identification of SIN pathway targets reveals mechanisms of crosstalk between NDR kinase pathways.

Gupta S et al. Curr Biol 2013 Feb 18;23(4):333-8

PMID:27474797 - Spatial control of translation repression and polarized growth by conserved NDR kinase Orb6 and RNA-binding protein Sts5.

Nuñez I et al. Elife 2016 Jul 30;5

PMID:22629372 - Conserved Orb6 phosphorylation sites are essential for polarized cell growth in Schizosaccharomyces pombe.

Liu G et al. PLoS One 2012;7(5):e37221

PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36

PMID:27298342 - Identification of S-phase DNA damage-response targets in fission yeast reveals conservation of damage-response networks.

Willis NA et al. Proc Natl Acad Sci U S A 2016 Jun 28;113(26):E3676-85

PMID:34523683 - Cdc42 reactivation at growth sites is regulated by local cell-cycle-dependent loss of its GTPase-activating protein Rga4 in fission yeast.

Rich-Robinson J et al. J Cell Sci 2021 Oct 01;134(19)

PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.

Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7