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protein coding gene - rct1 (SPBC17G9.05) - cyclophilin family peptidyl-prolyl cis-trans isomerase, RRM-containing Rct1

Gene summary

Standard name
rct1
Systematic ID
SPBC17G9.05
Product
cyclophilin family peptidyl-prolyl cis-trans isomerase, RRM-containing Rct1
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
cyp6
UniProt ID
Q9UUE4
ORFeome ID
22/22E11
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome II: 2177773..2179449 forward strand

Annotation

GO biological process

GO:0006357 - regulation of transcription by RNA polymerase II

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GO cellular component

GO:0000785 - chromatin

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GO:0005634 - nucleus

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GO molecular function

GO:0003755 - peptidyl-prolyl cis-trans isomerase activity

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GO:0003723 - RNA binding

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Modification

MOD:00046 - O-phospho-L-serine

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MOD:00047 - O-phospho-L-threonine

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MOD:00048 - O4'-phospho-L-tyrosine

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MOD:00696 - phosphorylated residue

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Protein features

PBO:0111764 - rrm RNA recognition motif

Qualitative gene expression

PomGeneEx:0000011 - RNA level increased

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Quantitative gene expression

PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0000350 - abnormal actin cytoskeleton morphology during vegetative growth

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Genotypes:

FYPO:0000026 - abnormal vegetative cell polarity

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Genotypes:

FYPO:0004067 - decreased phosphorylation of RNA polymerase II C-terminal domain serine 2 residues during vegetative growth

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Genotypes:

FYPO:0004068 - decreased phosphorylation of RNA polymerase II C-terminal domain serine 5 residues during vegetative growth

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Genotypes:

FYPO:0000584 - decreased sporulation frequency

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Genotypes:

FYPO:0005229 - decreased transcription from RNA polymerase II promoter during vegetative growth

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Genotypes:

FYPO:0000636 - increased cell population growth rate

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Genotypes:

FYPO:0001043 - increased mating efficiency

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Genotypes:

FYPO:0005041 - increased phosphorylation of RNA polymerase II C-terminal domain serine 2 residues during vegetative growth

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Genotypes:

FYPO:0005184 - increased phosphorylation of RNA polymerase II C-terminal domain serine 5 residues during vegetative growth

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Genotypes:

FYPO:0004557 - increased vegetative cell population growth

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Genotypes:

FYPO:0002430 - inviable after spore germination, multiple cell divisions

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Genotypes:

FYPO:0002061 - inviable vegetative cell population

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Genotypes:

FYPO:0000245 - loss of viability in stationary phase

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Genotypes:

FYPO:0000764 - resistance to cycloheximide

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Genotypes:

FYPO:0001453 - resistance to ethanol

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Genotypes:

FYPO:0002578 - resistance to hydroxyurea

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Genotypes:

FYPO:0009087 - resistance to magnesium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0009039 - resistance to potassium chloride

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Genotypes:

FYPO:0009081 - resistance to potassium chloride and methyl methanesulfonate

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Genotypes:

FYPO:0009043 - resistance to potassium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0003383 - resistance to tert-butyl hydroperoxide

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Genotypes:

FYPO:0001034 - resistance to tunicamycin

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Genotypes:

FYPO:0001234 - slow vegetative cell population growth

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Genotypes:

FYPO:0002106 - viable stubby vegetative cell

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Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0000055 - no apparent S. cerevisiae ortholog

PBO:0006222 - predominantly single copy (one to one)

Warnings

PBO:0091770 - The Bioneer strain does not appear contain a deletion

Protein features

IDNameInterPro nameDB name
PF00076RRM_1RRM_domPFAM
PF00160Pro_isomeraseCyclophilin-type_PPIase_domPFAM
cd01921cyclophilin_RRMCyclophilin_PPIL4CDD
cd12235RRM_PPIL4CDD
PS50072CSA_PPIASE_2Cyclophilin-type_PPIase_domPROSITE_PROFILES
PS50102RRMRRM_domPROSITE_PROFILES
SM00360rrm1_1RRM_domSMART
PR00153CSAPPISMRASECyclophilin-type_PPIase_domPRINTS
G3DSA:2.40.100.10:FF:000015FUNFAM
G3DSA:3.30.70.330:FF:000287FUNFAM
SSF54928RNA-binding domain, RBDRBD_domain_sfSUPERFAMILY
SSF50891Cyclophilin-likeCyclophilin-like_dom_sfSUPERFAMILY
G3DSA:3.30.70.330Nucleotide-bd_a/b_plait_sfGENE3D
G3DSA:2.40.100.10Cyclophilin-like_dom_sfGENE3D
PTHR45843PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-LIKE 4CRIPPANTHER
mobidb-lite-Disorderdisorder_predictionMOBIDB-Disorder
mobidb-lite-Polyampholytedisorder_predictionMOBIDB-Polyampholyte

Orthologs

References / Literature

GO_REF:0000051 - S. pombe keyword mapping
PMID:12161753 - The transcriptional program of meiosis and sporulation in fission yeast.
Mata J et al. Nat Genet 2002 Sep;32(1):143-7
PMID:34250083 - Barcode sequencing and a high-throughput assay for chronological lifespan uncover ageing-associated genes in fission yeast.
Romila CA et al. Microb Cell 2021 Jul 05;8(7):146-160
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:20118936 - Schizosaccharomyces pombe genome-wide nucleosome mapping reveals positioning mechanisms distinct from those of Saccharomyces cerevisiae.
Lantermann AB et al. Nat Struct Mol Biol 2010 Feb;17(2):251-7
PMID:28636937 - The Conserved RNA Binding Cyclophilin, Rct1, Regulates Small RNA Biogenesis and Splicing Independent of Heterochromatin Assembly.
Chang AY et al. Cell Rep 2017 Jun 20;19(12):2477-2489
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:23163955 - Analysis of stress-induced duplex destabilization (SIDD) properties of replication origins, genes and intergenes in the fission yeast, Schizosaccharomyces pombe.
Yadav MP et al. BMC Res Notes 2012 Nov 19;5:643
PMID:39476757 - Characterization of Ksg1 protein kinase-dependent phosphoproteome in the fission yeast S. pombe.
Cipak L et al. Biochem Biophys Res Commun 2024 Oct 25;736:150895
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.
Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.
Halova L et al. Open Biol 2021 Apr;11(4):200405
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.
Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:17339332 - Rct1, a nuclear RNA recognition motif-containing cyclophilin, regulates phosphorylation of the RNA polymerase II C-terminal domain.
Gullerova M et al. Mol Cell Biol 2007 May;27(10):3601-11
PMID:25452419 - Parallel profiling of fission yeast deletion mutants for proliferation and for lifespan during long-term quiescence.
Sideri T et al. G3 (Bethesda) 2014 Dec 01;5(1):145-55
PMID:26167880 - SR protein kinases promote splicing of nonconsensus introns.
Lipp JJ et al. Nat Struct Mol Biol 2015 Aug;22(8):611-7
GO_REF:0000116 - Automatic Gene Ontology annotation based on Rhea mapping.
PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.
Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963
PMID:29996109 - Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe.
Swaffer MP et al. Cell Rep 2018 Jul 10;24(2):503-514
PMID:19547744 - Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.
Beltrao P et al. PLoS Biol 2009 Jun 16;7(6):e1000134
PMID:38269097 - Rapamycin-sensitive mechanisms confine the growth of fission yeast below the temperatures detrimental to cell physiology.
Morozumi Y et al. iScience 2024 Jan 19;27(1):108777