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protein coding gene - pyr1 (SPBC17G9.11c) - pyruvate carboxylase Pyr1

Gene summary

Standard name
pyr1
Systematic ID
SPBC17G9.11c
Product
pyruvate carboxylase Pyr1
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
Q9UUE1
ORFeome ID
41/41A07
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome II: 2190645..2194537 reverse strand

Annotation

PBO:0003947 - 6.4.1.1

Disease association

MONDO:0004069 - inborn mitochondrial metabolism disorder

References:

MONDO:0005066 - metabolic disease

References:

MONDO:0009949 - pyruvate carboxylase deficiency disease

References:

GO biological process

GO:0006091 - generation of precursor metabolites and energy

References:

GO:0006094 - gluconeogenesis

References:

GO:0006090 - pyruvate metabolic process

References:

GO cellular component

GO:0005829 - cytosol

References:

GO molecular function

GO:0005524 - ATP binding

References:

GO:0046872 - metal ion binding

References:

GO:0004736 - pyruvate carboxylase activity

References:

Modification

MOD:01885 - biotinylated residue

References:

MOD:00595 - monomannosylated residue

References:

MOD:00126 - N6-biotinyl-L-lysine

References:

MOD:00123 - N6-carboxy-L-lysine

References:

MOD:00046 - O-phospho-L-serine

References:

MOD:00047 - O-phospho-L-threonine

References:

MOD:00048 - O4'-phospho-L-tyrosine

References:

MOD:00696 - phosphorylated residue

References:

MOD:01148 - ubiquitinylated lysine

References:

Qualitative gene expression

PomGeneEx:0000019 - protein level decreased

References:

PomGeneEx:0000011 - RNA level increased

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0000320 - inviable after spore germination, single cell division, normal cell morphology

References:

Genotypes:

FYPO:0000310 - inviable after spore germination, without cell division, with normal germ tube morphology

References:

Genotypes:

FYPO:0002151 - inviable spore

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

Taxonomic conservation

PBO:0011067 - conserved in bacteria

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF00289Biotin_carb_NBC-like_NPfam
PF00364Biotin_lipoylBiotin_lipoylPfam
PF00682HMGL-likePYR_CTPfam
PF02436PYC_OADACarboxylase_cons_domPfam
PF02785Biotin_carb_CBiotin_COase_CPfam
PF02786CPSase_L_D2CPAse_ATP-bdPfam
cd06850biotinyl_domainCDD
cd07937DRE_TIM_PC_TC_5SCDD
PS00188BIOTINBiotin_BSPROSITE patterns
PS00867CPSASE_2CPAse_ATP-bdPROSITE patterns
PS50968BIOTINYL_LIPOYLBiotin_lipoylPROSITE profiles
PS50975ATP_GRASPATP-graspPROSITE profiles
PS50979BCBiotin_carboxylation_domPROSITE profiles
PS50991PYR_CTPYR_CTPROSITE profiles
SM00878Biotin_carb_CBiotin_COase_CSMART
G3DSA:2.40.50.100:FF:000003CATH-FunFam
G3DSA:3.20.20.70:FF:000033CATH-FunFam
G3DSA:3.30.1490.20:FF:000018CATH-FunFam
G3DSA:3.30.470.20:FF:000012CATH-FunFam
G3DSA:3.40.50.20:FF:000010CATH-FunFam
G3DSA:2.40.50.100CATH-Gene3D
G3DSA:3.20.20.70Aldolase_TIMCATH-Gene3D
G3DSA:3.30.470.20CATH-Gene3D
SSF51230Single_hybrid_motifSUPERFAMILY
SSF51246Rudment_hybrid_motifSUPERFAMILY
SSF51569SUPERFAMILY
SSF52440PreATP-grasp_dom_sfSUPERFAMILY
SSF56059SUPERFAMILY
SSF89000SUPERFAMILY
PTHR43778PCB-likePANTHER
PIRSF001594Pyruv_carboxPyruv_COasePIRSF
NF006761PRK09282.1NCBIFAM
NF009554PRK12999.1NCBIFAM
TIGR01235pyruv_carboxPyruv_COaseNCBIFAM

Orthologs

References / Literature

GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:21712547 - Mitotic substrates of the kinase aurora with roles in chromatin regulation identified through quantitative phosphoproteomics of fission yeast.
Koch A et al. Sci Signal 2011 Jun 28;4(179):rs6
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.
Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:36408920 - UniProt: the Universal Protein Knowledgebase in 2023.
UniProt Consortium Nucleic Acids Res 2023 Jan 06;51(D1):D523-D531
PMID:36478272 - Translation-complex profiling of fission yeast cells reveals dynamic rearrangements of scanning ribosomal subunits upon nutritional stress.
Duncan CDS et al. Nucleic Acids Res 2022 Dec 09;50(22):13011-13025
PB_REF:0000001 - Protein modification annotation by manual transfer of experimentally-verified annotation data to orthologs based on curator judgment of sequence features.
GO_REF:0000002 - Comments
PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.
Halova L et al. Open Biol 2021 Apr;11(4):200405
PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.
Strachan J et al. J Cell Sci 2023 Dec 01;136(23)
PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.
Skribbe M et al. Mol Cell 2025 Feb 19;
PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.
Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963
PMID:26644575 - Discovery of a nucleocytoplasmic O-mannose glycoproteome in yeast.
Halim A et al. Proc Natl Acad Sci U S A 2015 Dec 22;112(51):15648-53
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:28218250 - Chromatin remodeller Fun30 Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.
Lee J et al. Nat Commun 2017 Feb 20;8:14527
PMID:26412298 - A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.
Beckley JR et al. Mol Cell Proteomics 2015 Dec;14(12):3132-41
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.
Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87
PMID:26152728 - A Two-step Protein Quality Control Pathway for a Misfolded DJ-1 Variant in Fission Yeast.
Mathiassen SG et al. J Biol Chem 2015 Aug 21;290(34):21141-21153
PMID:29432178 - General amino acid control in fission yeast is regulated by a nonconserved transcription factor, with functions analogous to Gcn4/Atf4.
Duncan CDS et al. Proc Natl Acad Sci U S A 2018 Feb 20;115(8):E1829-E1838
PB_REF:0000003 - Disease Association Curation
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
GO_REF:0000051 - S. pombe keyword mapping
PMID:19547744 - Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.
Beltrao P et al. PLoS Biol 2009 Jun 16;7(6):e1000134
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6