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protein coding gene - cup1 (SPBC17G9.13c) - mitochondrial LYR family protein Cup1/Lyr1

Gene summary

Standard name
cup1
Systematic ID
SPBC17G9.13c
Product
mitochondrial LYR family protein Cup1/Lyr1
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
lyr1
UniProt ID
Q9UUD9
ORFeome ID
13/13D12
Characterisation status
biological role inferred
Feature type
mRNA gene
Genomic location
chromosome II: 2196424..2197741 reverse strand

Annotation

GO biological process

GO:0140053 - mitochondrial gene expression

References:

GO cellular component

GO:0005739 - mitochondrion

References:

Modification

MOD:00046 - O-phospho-L-serine

References:

Protein features

PBO:0111754 - LYR family

Qualitative gene expression

PomGeneEx:0000019 - protein level decreased

References:

Quantitative gene expression

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0002151 - inviable spore

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

FYPO:0000073 - resistance to caffeine

References:

Genotypes:

FYPO:0002766 - resistance to clotrimazole

References:

Genotypes:

FYPO:0007033 - resistance to fluconazole

References:

Genotypes:

FYPO:0007716 - resistance to tebuconazole

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Genotypes:

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

Taxonomic conservation

PBO:0011064 - conserved in fungi

PBO:0011063 - conserved in fungi only

PBO:0000055 - no apparent S. cerevisiae ortholog

Protein features

IDNameInterPro nameDB name
PF20263LYRM2-likeCup1-like_NPFAM

Orthologs

References / Literature

PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:25375137 - Systematic analysis of the role of RNA-binding proteins in the regulation of RNA stability.
Hasan A et al. PLoS Genet 2014 Nov;10(11):e1004684
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:32908306 - Epigenetic gene silencing by heterochromatin primes fungal resistance.
Torres-Garcia S et al. Nature 2020 Sep;585(7825):453-458
GO_REF:0000051 - S. pombe keyword mapping
PMID:39094565 - Mapping the dynamics of epigenetic adaptation in S. pombe during heterochromatin misregulation.
Larkin A et al. Dev Cell 2024 Jul 26;
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.
Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105