PomBase - protein coding gene - mot1 (SPBC1826.01c) - TATA-binding protein-associated transcription initiation factor Mot1 - The Schizosaccharomyces pombe genome database

Protein features

ID	Name	InterPro name	DB name
PF00176	SNF2-rel_dom	SNF2_N	PFAM
PF12054	DUF3535	Mot1_central_dom	PFAM
PF00271	Helicase_C	Helicase_C-like	PFAM
cd18793	SF2_C_SNF	SNF2/RAD54-like_C	CDD
cd17999	DEXHc_Mot1	Mot1_ATP-bd	CDD
PS51194	HELICASE_CTER	Helicase_C-like	PROSITE_PROFILES
PS51192	HELICASE_ATP_BIND_1	Helicase_ATP-bd	PROSITE_PROFILES
SM00487	ultradead3	Helicase_ATP-bd	SMART
SM00490	helicmild6	Helicase_C-like	SMART
G3DSA:1.25.10.10:FF:000508			FUNFAM
G3DSA:1.25.10.10:FF:000445			FUNFAM
G3DSA:3.40.50.300:FF:000428			FUNFAM
G3DSA:3.40.50.10810:FF:000009			FUNFAM
SSF48371	ARM repeat	ARM-type_fold	SUPERFAMILY
SSF52540	P-loop containing nucleoside triphosphate hydrolases	P-loop_NTPase	SUPERFAMILY
G3DSA:1.25.10.10		ARM-like	GENE3D
G3DSA:3.40.50.300		P-loop_NTPase	GENE3D
G3DSA:3.40.50.10810		SNF2-like_sf	GENE3D
PTHR36498	TATA-BINDING PROTEIN-ASSOCIATED FACTOR 172	Mot1	PANTHER
mobidb-lite-Disorder	disorder_prediction		MOBIDB-Disorder
mobidb-lite-Low-complexity	disorder_prediction		MOBIDB-Low-complexity
mobidb-lite-Polar	disorder_prediction		MOBIDB-Polar
mobidb-lite-Polyampholyte	disorder_prediction		MOBIDB-Polyampholyte

References / Literature

GO_REF:0000002 - Comments
PMID:21511999 - Comparative functional genomics of the fission yeasts.: Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.: Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
PMID:18257517 - Phosphoproteome analysis of fission yeast.: Wilson-Grady JT et al. J Proteome Res 2008 Mar;7(3):1088-97
PMID:27298342 - Identification of S-phase DNA damage-response targets in fission yeast reveals conservation of damage-response networks.: Willis NA et al. Proc Natl Acad Sci U S A 2016 Jun 28;113(26):E3676-85
GO_REF:0000111 - Gene Ontology annotations Inferred by Curator (IC) using at least one Inferred by Sequence Similarity (ISS) annotation to support the inference
PMID:22540037 - Predicting the fission yeast protein interaction network.: Pancaldi V et al. G3 (Bethesda) 2012 Apr;2(4):453-67
PMID:21712547 - Mitotic substrates of the kinase aurora with roles in chromatin regulation identified through quantitative phosphoproteomics of fission yeast.: Koch A et al. Sci Signal 2011 Jun 28;4(179):rs6
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.: Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.: Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87
PMID:31474649 - Identification of 15 New Bypassable Essential Genes of Fission Yeast.: Takeda A et al. Cell Struct Funct 2019 Sep 27;44(2):113-119
PMID:19547744 - Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.: Beltrao P et al. PLoS Biol 2009 Jun 16;7(6):e1000134
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.: Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.: Halova L et al. Open Biol 2021 Apr;11(4):200405
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).: Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:29996109 - Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe.: Swaffer MP et al. Cell Rep 2018 Jul 10;24(2):503-514
GO_REF:0000051 - S. pombe keyword mapping
PMID:24013502 - Epe1 recruits BET family bromodomain protein Bdf2 to establish heterochromatin boundaries.: Wang J et al. Genes Dev 2013 Sep 01;27(17):1886-902
PMID:27984725 - CDK Substrate Phosphorylation and Ordering the Cell Cycle.: Swaffer MP et al. Cell 2016 Dec 15;167(7):1750-1761.e16
PMID:28218250 - Chromatin remodeller Fun30 Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.: Lee J et al. Nat Commun 2017 Feb 20;8:14527
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.: Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:39476757 - Characterization of Ksg1 protein kinase-dependent phosphoproteome in the fission yeast S. pombe.: Cipak L et al. Biochem Biophys Res Commun 2024 Oct 25;736:150895
PMID:26537787 - Targeting of SUMO substrates to a Cdc48-Ufd1-Npl4 segregase and STUbL pathway in fission yeast.: Køhler JB et al. Nat Commun 2015 Nov 05;6:8827
PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.: Skribbe M et al. Mol Cell 2025 Feb 19;
PMID:12161753 - The transcriptional program of meiosis and sporulation in fission yeast.: Mata J et al. Nat Genet 2002 Sep;32(1):143-7
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.: Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

protein coding gene - mot1 (SPBC1826.01c) - TATA-binding protein-associated transcription initiation factor Mot1

Gene summary

Annotation

GO biological process

GO:0006367 - transcription initiation at RNA polymerase II promoter

GO cellular component

GO:0005634 - nucleus

GO molecular function

GO:0005524 - ATP binding

GO:0016887 - ATP hydrolysis activity

GO:0003677 - DNA binding

GO:0016251 - RNA polymerase II general transcription initiation factor activity

GO:0017025 - TBP-class protein binding

Modification

MOD:00046 - O-phospho-L-serine

MOD:00047 - O-phospho-L-threonine

MOD:00696 - phosphorylated residue

MOD:01149 - sumoylated lysine

Protein features

PBO:0111765 - HEAT repeat

Qualitative gene expression

PomGeneEx:0000011 - RNA level increased

Quantitative gene expression

PBO:0006310 - protein level

PBO:0011963 - RNA level

Single locus phenotype

FYPO:0000311 - inviable after spore germination with normal, unseptated germ tube morphology

FYPO:0002061 - inviable vegetative cell population

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

Orthologs

References / Literature