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protein coding gene - prp24 (SPBC1861.04c) - RNA-binding protein Prp24

Gene summary

Standard name
prp24
Systematic ID
SPBC1861.04c
Product
RNA-binding protein Prp24
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
Q9USY2
ORFeome ID
48/48A12
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome II: 4135960..4139238 reverse strand

Annotation

GO biological process

GO:0000245 - spliceosomal complex assembly

References:

GO:0000244 - spliceosomal tri-snRNP complex assembly

References:

GO cellular component

GO:0005634 - nucleus

References:

GO:0005688 - U6 snRNP

References:

GO molecular function

GO:0017069 - snRNA binding

References:

Modification

MOD:00046 - O-phospho-L-serine

References:

MOD:01149 - sumoylated lysine

References:

Protein features

PBO:0111764 - rrm RNA recognition motif

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0000059 - abnormal mitotic cell cycle

References:

Genotypes:

FYPO:0000314 - inviable after spore germination with elongated germ tube

References:

Genotypes:

FYPO:0003529 - inviable after spore germination, multiple cell divisions, cell cycle arrest in mitotic interphase, elongated cells

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF00076RRM_1RRM_domPfam
PF05391Lsm_interactLSM_interactPfam
PF05843SufSufPfam
PF16842RRM_occludedRRM_occludedPfam
cd12296RRM1_Prp24Prp24_RRM1CDD
cd12297RRM2_Prp24Prp24_RRM2CDD
cd12299RRM4_Prp24RRM_occludedCDD
cd21619RRM1_Crp79CDD
PS50102RRMRRM_domPROSITE profiles
SM00360RRMRRM_domSMART
SM00386HATHATSMART
G3DSA:3.30.70.330:FF:000365CATH-FunFam
G3DSA:3.30.70.330:FF:000588CATH-FunFam
G3DSA:1.25.40.10TPR-like_helical_dom_sfCATH-Gene3D
G3DSA:3.30.70.330Nucleotide-bd_a/b_plait_sfCATH-Gene3D
SSF48452TPR-like_helical_dom_sfSUPERFAMILY
SSF54928RBD_domain_sfSUPERFAMILY
PTHR48025Euk_RNA-bind_protPANTHER
CoilCOILS
mobidb-lite-Disorderdisorder_predictionMobiDB-Disorder
mobidb-lite-Polardisorder_predictionMobiDB-Polar
mobidb-lite-Polyampholytedisorder_predictionMobiDB-Polyampholyte

Orthologs

References / Literature

PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.
Halova L et al. Open Biol 2021 Apr;11(4):200405
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.
Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:37403782 - The fission yeast methyl phosphate capping enzyme Bmc1 guides 2'-O-methylation of the U6 snRNA.
Porat J et al. Nucleic Acids Res 2023 Sep 08;51(16):8805-8819
PMID:32518066 - Molecular basis for the distinct cellular functions of the Lsm1-7 and Lsm2-8 complexes.
Montemayor EJ et al. RNA 2020 Oct;26(10):1400-1413
PMID:28446597 - The histone variant H2A.Z promotes splicing of weak introns.
Nissen KE et al. Genes Dev 2017 Apr 01;31(7):688-701
PMID:28947618 - Sde2 is an intron-specific pre-mRNA splicing regulator activated by ubiquitin-like processing.
Thakran P et al. EMBO J 2018 Jan 04;37(1):89-101
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:26537787 - Targeting of SUMO substrates to a Cdc48-Ufd1-Npl4 segregase and STUbL pathway in fission yeast.
Køhler JB et al. Nat Commun 2015 Nov 05;6:8827