protein coding gene - lcb1 (SPBC18E5.02c) - serine palmitoyltransferase complex subunit

Gene summary

Standard name: lcb1
Systematic ID: SPBC18E5.02c
Product: serine palmitoyltransferase complex subunit
Organism: Schizosaccharomyces pombe (fission yeast)
Synonyms: SPBC29A3.20c
UniProt ID: O59682
ORFeome ID: 35/35D03
Characterisation status: biological role inferred
Feature type: mRNA gene
Genomic location: chromosome II: 2076986..2078981 reverse strand

Annotation

PBO:0002442 - 2.3.1.50

Disease association

MONDO:0859529 - amyotrophic lateral sclerosis 27, juvenile

References:

PB_REF:0000006

MONDO:0008086 - neuropathy, hereditary sensory and autonomic, type 1A

References:

PB_REF:0000006

GO biological process

GO:0046513 - ceramide biosynthetic process

References:

GO_REF:0000033

GO:0046512 - sphingosine biosynthetic process

References:

GO_REF:0000033

GO cellular component

GO:0005783 - endoplasmic reticulum

References:

PMID:16823372

GO:0017059 - serine palmitoyltransferase complex

References:

GO_REF:0000024

GO molecular function

GO:0030170 - pyridoxal phosphate binding

References:

GO_REF:0000002

GO:0004758 - serine C-palmitoyltransferase activity

References:

GO_REF:0000033

Modification

MOD:00046 - O-phospho-L-serine

References:

PMID:25720772

MOD:01148 - ubiquitinylated lysine

References:

PMID:37970674

Qualitative gene expression

PomGeneEx:0000018 - protein level increased

References:

PMID:39367033

PomGeneEx:0000011 - RNA level increased

References:

PMID:16537923

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

PMID:23101633

Single locus phenotype

FYPO:0000311 - inviable after spore germination with normal, unseptated germ tube morphology

References:

PMID:23697806

Genotypes:

lcb1delta

FYPO:0002151 - inviable spore

References:

PMID:23697806

Genotypes:

lcb1delta

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

lcb1delta

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

ID	Name	InterPro name	DB name
PF00155	Aminotran_1_2	Aminotransferase_I/II_large	PFAM
G3DSA:3.40.640.10:FF:000049			FUNFAM
SSF53383	PLP-dependent transferases	PyrdxlP-dep_Trfase	SUPERFAMILY
G3DSA:3.90.1150.10	Aspartate Aminotransferase, domain 1	PyrdxlP-dep_Trfase_small	GENE3D
G3DSA:3.40.640.10		PyrdxlP-dep_Trfase_major	GENE3D
PTHR13693	CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE	AON_synthase_class-II	PANTHER

Orthologs

SPTLC1 (HGNC:11277) Homo sapiens
lcb1 (SJAG_04178) Schizosaccharomyces japonicus
LCB1 (YMR296C) Saccharomyces cerevisiae

References / Literature

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.: Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:34805795 - The fission yeast FLCN/FNIP complex augments TORC1 repression or activation in response to amino acid (AA) availability.: Calvo IA et al. iScience 2021 Nov 19;24(11):103338
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.: Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.: Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
GO_REF:0000002 - Comments
PMID:22119525 - SIN-inhibitory phosphatase complex promotes Cdc11p dephosphorylation and propagates SIN asymmetry in fission yeast.: Singh NS et al. Curr Biol 2011 Dec 06;21(23):1968-78
PMID:26412298 - A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.: Beckley JR et al. Mol Cell Proteomics 2015 Dec;14(12):3132-41
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.: Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.: Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:16537923 - Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.: Todd BL et al. Mol Cell Biol 2006 Apr;26(7):2817-31
PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.: Strachan J et al. J Cell Sci 2023 Dec 01;136(23)
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).: Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:31474649 - Identification of 15 New Bypassable Essential Genes of Fission Yeast.: Takeda A et al. Cell Struct Funct 2019 Sep 27;44(2):113-119
PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.: Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87
PMID:21511999 - Comparative functional genomics of the fission yeasts.: Rhind N et al. Science 2011 May 20;332(6032):930-6