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protein coding gene - mas2 (SPBC18E5.12c) - mitochondrial processing peptidase (MPP) complex substrate recognition (alpha) subunit Mas2

Gene summary

Standard name
mas2
Systematic ID
SPBC18E5.12c
Product
mitochondrial processing peptidase (MPP) complex substrate recognition (alpha) subunit Mas2
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
SPBC23G7.02c
UniProt ID
O94745
ORFeome ID
23/23H12
Characterisation status
biological role inferred
Feature type
mRNA gene
Genomic location
chromosome II: 2096447..2098025 reverse strand

Annotation

PBO:0003867 - 3.4.24.64

Disease association

MONDO:0008943 - autosomal recessive spinocerebellar ataxia 2

References:

MONDO:0004069 - inborn mitochondrial metabolism disorder

References:

MONDO:0005071 - nervous system disorder

References:

GO biological process

GO:0034982 - mitochondrial protein processing

References:

GO cellular component

GO:0017087 - mitochondrial processing peptidase complex

References:

GO:0005739 - mitochondrion

References:

GO molecular function

GO:0046872 - metal ion binding

References:

GO:0004222 - metalloendopeptidase activity

References:

Qualitative gene expression

PomGeneEx:0000019 - protein level decreased

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0000311 - inviable after spore germination with normal, unseptated germ tube morphology

References:

Genotypes:

FYPO:0002151 - inviable spore

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Warnings

PBO:0000070 - gene structure updated

References:

Protein features

IDNameInterPro nameDB name
PF05193Peptidase_M16_CPeptidase_M16_CPFAM
PF00675Peptidase_M16Pept_M16_NPFAM
PS00143INSULINASEPept_M16_Zn_BSPROSITE_PATTERNS
G3DSA:3.30.830.10:FF:000023FUNFAM
SSF63411LuxS/MPP-like metallohydrolaseMetalloenz_LuxS/M16SUPERFAMILY
G3DSA:3.30.830.10GENE3D
PTHR11851METALLOPROTEASEMPP/UQCRC_ComplexPANTHER

Orthologs

References / Literature

PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:16802154 - Enhanced productivity of protease-sensitive heterologous proteins by disruption of multiple protease genes in the fission yeast Schizosaccharomyces pombe.
Idiris A et al. Appl Microbiol Biotechnol 2006 Nov;73(2):404-20
PMID:16491466 - Construction of a protease-deficient strain set for the fission yeast Schizosaccharomyces pombe, useful for effective production of protease-sensitive heterologous proteins.
Idiris A et al. Yeast 2006 Jan 30;23(2):83-99
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:22540037 - Predicting the fission yeast protein interaction network.
Pancaldi V et al. G3 (Bethesda) 2012 Apr;2(4):453-67
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:37156397 - Identification of novel coenzyme Q 10 biosynthetic proteins Coq11 and Coq12 in Schizosaccharomyces pombe.
Nishida I et al. J Biol Chem 2023 Jun;299(6):104797
PMID:9737975 - Role of alpha-subunit of mitochondrial processing peptidase in substrate recognition.
Shimokata K et al. J Biol Chem 1998 Sep 25;273(39):25158-63
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.
Skribbe M et al. Mol Cell 2025 Feb 19;
GO_REF:0000002 - Comments
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:31474649 - Identification of 15 New Bypassable Essential Genes of Fission Yeast.
Takeda A et al. Cell Struct Funct 2019 Sep 27;44(2):113-119
PB_REF:0000003 - Disease Association Curation
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623