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protein coding gene - any1 (SPBC18H10.20c) - arrestin family ubiquitin ligase substrate adaptor Any1

Gene summary

Standard name
any1
Systematic ID
SPBC18H10.20c
Product
arrestin family ubiquitin ligase substrate adaptor Any1
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
arn1, art1, can1
UniProt ID
O60150
ORFeome ID
16/16H08
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome II: 1808258..1810319 reverse strand

Annotation

Complementation

PBO:0011140 - functionally complemented by S. cerevisiae CAN1

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GO biological process

GO:0072583 - clathrin-dependent endocytosis

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GO cellular component

GO:0030136 - clathrin-coated vesicle

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GO:0005829 - cytosol

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GO:0005794 - Golgi apparatus

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GO:0005886 - plasma membrane

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GO molecular function

GO:0005515 - protein binding

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GO:0031625 - ubiquitin protein ligase binding

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GO:1990756 - ubiquitin-like ligase-substrate adaptor activity

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Modification

MOD:00047 - O-phospho-L-threonine

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MOD:01148 - ubiquitinylated lysine

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Multi-locus phenotype

FYPO:0001407 - decreased cell population growth on glucose carbon source

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Genotypes:

FYPO:0010038 - decreased protein localization to Golgi apparatus, with protein mislocalized to plasma membrane

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Genotypes:

FYPO:0001152 - decreased RNA level during nitrogen starvation

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Genotypes:

FYPO:0001355 - decreased vegetative cell population growth

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Genotypes:

FYPO:0000825 - increased RNA level during vegetative growth

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Genotypes:

FYPO:0002674 - normal protein localization to plasma membrane

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Genotypes:

FYPO:0001357 - normal vegetative cell population growth

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Genotypes:

FYPO:0001029 - resistance to canavanine

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Genotypes:

FYPO:0000099 - sensitive to canavanine

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Genotypes:

Qualitative gene expression

PomGeneEx:0000012 - RNA level decreased

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Quantitative gene expression

PBO:0006310 - protein level

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PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0000421 - abolished endocytosis during vegetative growth

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Genotypes:

FYPO:0010004 - abolished protein localization to plasma membrane during cellular response to nitrogen starvation

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Genotypes:

FYPO:0000912 - abolished protein ubiquitination during vegetative growth

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Genotypes:

FYPO:0000705 - abolished protein-protein interaction

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Genotypes:

FYPO:0001592 - decreased arginine import

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Genotypes:

FYPO:0000080 - decreased cell population growth at low temperature

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Genotypes:

FYPO:0001407 - decreased cell population growth on glucose carbon source

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Genotypes:

FYPO:0005226 - decreased level of ubiquitinated protein in cell

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Genotypes:

FYPO:0001324 - decreased protein level during vegetative growth

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Genotypes:

FYPO:0010038 - decreased protein localization to Golgi apparatus, with protein mislocalized to plasma membrane

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Genotypes:

FYPO:0002768 - decreased protein ubiquitination during vegetative growth

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Genotypes:

FYPO:0001645 - decreased protein-protein interaction

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Genotypes:

FYPO:0001355 - decreased vegetative cell population growth

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Genotypes:

FYPO:0000425 - increased endocytosis during vegetative growth

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Genotypes:

FYPO:0001327 - increased protein level during vegetative growth

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Genotypes:

FYPO:0002127 - increased protein localization to plasma membrane during vegetative growth

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Genotypes:

FYPO:0002332 - normal protein localization to Golgi apparatus

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Genotypes:

FYPO:0001096 - normal RNA level during nitrogen starvation

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Genotypes:

FYPO:0002085 - normal vegetative cell growth

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Genotypes:

FYPO:0002714 - protein mislocalized to Golgi apparatus

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Genotypes:

FYPO:0000067 - resistance to brefeldin A

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Genotypes:

FYPO:0001029 - resistance to canavanine

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Genotypes:

FYPO:0002693 - resistance to diamide

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Genotypes:

FYPO:0009038 - resistance to egtazic acid

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Genotypes:

FYPO:0001453 - resistance to ethanol

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Genotypes:

FYPO:0001583 - resistance to lithium

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Genotypes:

FYPO:0009087 - resistance to magnesium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0009043 - resistance to potassium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0000096 - sensitive to cadmium

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Genotypes:

FYPO:0000099 - sensitive to canavanine

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Genotypes:

FYPO:0000842 - sensitive to ethanol during vegetative growth

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Genotypes:

FYPO:0002060 - viable vegetative cell population

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Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

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Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011063 - conserved in fungi only

PBO:0006222 - predominantly single copy (one to one)

Warnings

PBO:0091745 - SPBC18H10.16 was previously designated as can1

References:

Protein features

IDNameInterPro nameDB name
PF13002LDB19LDB19_NPFAM
G3DSA:2.60.40.640:FF:000063FUNFAM
G3DSA:2.60.40.640Arrestin-like_C_sfGENE3D

Orthologs

References / Literature

PMID:23813957 - The fission yeast β-arrestin-like protein Any1 is involved in TSC-Rheb signaling and the regulation of amino acid transporters.
Nakase Y et al. J Cell Sci 2013 Sep 01;126(Pt 17):3972-81
PMID:29199950 - Ragulator and GATOR1 complexes promote fission yeast growth by attenuating TOR complex 1 through Rag GTPases.
Chia KH et al. Elife 2017 Dec 04;6
PMID:26412298 - A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.
Beckley JR et al. Mol Cell Proteomics 2015 Dec;14(12):3132-41
PMID:2020549 - Budding yeast CAN1 gene as a selection marker in fission yeast.
Ekwall K et al. Nucleic Acids Res 1991 Mar 11;19(5):1150
PMID:24876389 - Fission yeast arrestin-related trafficking adaptor, Arn1/Any1, is ubiquitinated by Pub1 E3 ligase and regulates endocytosis of Cat1 amino acid transporter.
Nakashima A et al. Biol Open 2014 May 29;3(6):542-52
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:35770973 - Adaptor linked K63 di-ubiquitin activates Nedd4/Rsp5 E3 ligase.
Zhu L et al. Elife 2022 Jun 30;11
PMID:36626373 - Using canavanine resistance to measure mutation rates in Schizosaccharomyces pombe.
Pai CC et al. PLoS One 2023;18(1):e0271016
PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.
Strachan J et al. J Cell Sci 2023 Dec 01;136(23)
PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.
Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704
PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.
Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.
Skribbe M et al. Mol Cell 2025 Feb 19;
PMID:25375137 - Systematic analysis of the role of RNA-binding proteins in the regulation of RNA stability.
Hasan A et al. PLoS Genet 2014 Nov;10(11):e1004684
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
GO_REF:0000111 - Gene Ontology annotations Inferred by Curator (IC) using at least one Inferred by Sequence Similarity (ISS) annotation to support the inference
PMID:39476757 - Characterization of Ksg1 protein kinase-dependent phosphoproteome in the fission yeast S. pombe.
Cipak L et al. Biochem Biophys Res Commun 2024 Oct 25;736:150895
PMID:9950674 - Liz1p, a novel fission yeast membrane protein, is required for normal cell division when ribonucleotide reductase is inhibited.
Moynihan EB et al. Mol Biol Cell 1999 Feb;10(2):245-57
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:35639710 - Characterization of canavanine-resistance of cat1 and vhc1 deletions and a dominant any1 mutation in fission yeast.
Ait Saada A et al. PLoS One 2022;17(5):e0269276
PMID:1356078 - Thialysine-resistant mutants and uptake of lysine in Schizosaccharomyces pombe.
Sychrová H et al. Curr Genet 1992 Apr;21(4-5):351-5
PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.
Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.
Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963
PMID:18357653 - Canavanine resistance and the mechanism of arginine uptake in the fission yeast Schizosaccharomyces pombe.
Fantes PA et al. J Gen Microbiol 1984 Dec;130(12):3265-73
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:34296454 - The TOR-dependent phosphoproteome and regulation of cellular protein synthesis.
Mak T et al. EMBO J 2021 Aug 16;40(16):e107911
PMID:35300005 - Canavanine resistance mutation can1-1 in Schizosaccharomyces pombe is a missense mutation in the ubiquitin ligase adaptor gene any1 .
Yang YS et al. MicroPubl Biol 2022;2022
PMID:28218250 - Chromatin remodeller Fun30 Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.
Lee J et al. Nat Commun 2017 Feb 20;8:14527
PMID:36302945 - Ferrichrome, a fungal-type siderophore, confers high ammonium tolerance to fission yeast.
Chiu PC et al. Sci Rep 2022 Oct 27;12(1):17411
PMID:33534698 - Tripartite suppression of fission yeast TORC1 signaling by the GATOR1-Sea3 complex, the TSC complex, and Gcn2 kinase.
Fukuda T et al. Elife 2021 Feb 03;10
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83