protein coding gene - rad60 (SPBC1921.02) - DNA repair protein, SUMO-related Rad60

Gene summary

Standard name

rad60

Systematic ID

SPBC1921.02

Product

DNA repair protein, SUMO-related Rad60

Organism

Schizosaccharomyces pombe (fission yeast)

UniProt ID

Q9USX3

ORFeome ID

20/20D02

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome II: 2406820..2408273 forward strand

Annotation

Protein features

Orthologs

• NFATC2IP (HGNC:25906) Homo sapiens
• rad60 (SJAG_00177) Schizosaccharomyces japonicus
• ESC2 (YDR363W) Saccharomyces cerevisiae

References / Literature

PMID:18769921 - Genetic analysis reveals different roles of Schizosaccharomyces pombe sfr1/dds20 in meiotic and mitotic DNA recombination and repair.

Khasanov FK et al. Curr Genet 2008 Oct;54(4):197-211

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:21712547 - Mitotic substrates of the kinase aurora with roles in chromatin regulation identified through quantitative phosphoproteomics of fission yeast.

Koch A et al. Sci Signal 2011 Jun 28;4(179):rs6

PMID:27298342 - Identification of S-phase DNA damage-response targets in fission yeast reveals conservation of damage-response networks.

Willis NA et al. Proc Natl Acad Sci U S A 2016 Jun 28;113(26):E3676-85

PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.

Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105

PMID:21444718 - DNA repair and global sumoylation are regulated by distinct Ubc9 noncovalent complexes.

Prudden J et al. Mol Cell Biol 2011 Jun;31(11):2299-310

PMID:19755492 - Schizosaccharomyces pombe Cds1Chk2 regulates homologous recombination at stalled replication forks through the phosphorylation of recombination protein Rad60.

Miyabe I et al. J Cell Sci 2009 Oct 15;122(Pt 20):3638-43

PMID:26404184 - High Confidence Fission Yeast SUMO Conjugates Identified by Tandem Denaturing Affinity Purification.

Nie M et al. Sci Rep 2015 Sep 25;5:14389

PMID:21408210 - SUMO-targeted ubiquitin ligase, Rad60, and Nse2 SUMO ligase suppress spontaneous Top1-mediated DNA damage and genome instability.

Heideker J et al. PLoS Genet 2011 Mar;7(3):e1001320

PMID:11971984 - The Schizosaccharomyces pombe rad60 gene is essential for repairing double-strand DNA breaks spontaneously occurring during replication and induced by DNA-damaging agents.

Morishita T et al. Mol Cell Biol 2002 May;22(10):3537-48

PMID:20885950 - Characterisation of the SUMO-like domains of Schizosaccharomyces pombe Rad60.

Boyd LK et al. PLoS One 2010 Sep 27;5(9):e13009

PMID:19363481 - Molecular mimicry of SUMO promotes DNA repair.

Prudden J et al. Nat Struct Mol Biol 2009 May;16(5):509-16

PMID:15485909 - Rad62 protein functionally and physically associates with the smc5/smc6 protein complex and is required for chromosome integrity and recombination repair in fission yeast.

Morikawa H et al. Mol Cell Biol 2004 Nov;24(21):9401-13

PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.

Halova L et al. Open Biol 2021 Apr;11(4):200405

PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.

Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87

PMID:39476757 - Characterization of Ksg1 protein kinase-dependent phosphoproteome in the fission yeast S. pombe.

Cipak L et al. Biochem Biophys Res Commun 2024 Oct 25;736:150895

PMID:17762865 - SUMO-targeted ubiquitin ligases in genome stability.

Prudden J et al. EMBO J 2007 Sep 19;26(18):4089-101

PMID:16478984 - The Nse5-Nse6 dimer mediates DNA repair roles of the Smc5-Smc6 complex.

Pebernard S et al. Mol Cell Biol 2006 Mar;26(5):1617-30

PB_REF:0000001 - Protein modification annotation by manual transfer of experimentally-verified annotation data to orthologs based on curator judgment of sequence features.

PMID:22064477 - The RecQ4 orthologue Hrq1 is critical for DNA interstrand cross-link repair and genome stability in fission yeast.

Groocock LM et al. Mol Cell Biol 2012 Jan;32(2):276-87

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36

PMID:31474649 - Identification of 15 New Bypassable Essential Genes of Fission Yeast.

Takeda A et al. Cell Struct Funct 2019 Sep 27;44(2):113-119

PANTHER:PTHR10562 - Unknown title

PMID:19547744 - Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.

Beltrao P et al. PLoS Biol 2009 Jun 16;7(6):e1000134

PMID:16354704 - Rhp51-dependent recombination intermediates that do not generate checkpoint signal are accumulated in Schizosaccharomyces pombe rad60 and smc5/6 mutants after release from replication arrest.

Miyabe I et al. Mol Cell Biol 2006 Jan;26(1):343-53

PMID:27398807 - Functional Crosstalk between the PP2A and SUMO Pathways Revealed by Analysis of STUbL Suppressor, razor 1-1.

Nie M et al. PLoS Genet 2016 Jul;12(7):e1006165

PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.

Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:16880212 - SUMO-binding motifs mediate the Rad60-dependent response to replicative stress and self-association.

Raffa GD et al. J Biol Chem 2006 Sep 22;281(38):27973-81

PMID:29996109 - Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe.

Swaffer MP et al. Cell Rep 2018 Jul 10;24(2):503-514

PMID:19528228 - Smc5-Smc6-dependent removal of cohesin from mitotic chromosomes.

Outwin EA et al. Mol Cell Biol 2009 Aug;29(16):4363-75

PMID:12897162 - Replication checkpoint kinase Cds1 regulates recombinational repair protein Rad60.

Boddy MN et al. Mol Cell Biol 2003 Aug;23(16):5939-46