protein coding gene - pmt1 (SPBC19C2.02) - tRNA (cytosine-5-)-methyltransferase Pmt1

Gene summary

Standard name

pmt1

Systematic ID

SPBC19C2.02

Product

tRNA (cytosine-5-)-methyltransferase Pmt1

Organism

Schizosaccharomyces pombe (fission yeast)

Synonyms

dnmt2

UniProt ID

P40999

ORFeome ID

32/32D02

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome II: 1674026..1675523 forward strand

Annotation

Protein features

Orthologs

• TRDMT1 (HGNC:2977) Homo sapiens
• pmt1 (SJAG_01314) Schizosaccharomyces japonicus

References / Literature

PMID:26424849 - Dynamic modulation of Dnmt2-dependent tRNA methylation by the micronutrient queuine.

Müller M et al. Nucleic Acids Res 2015 Dec 15;43(22):10952-62

PMID:8636983 - Activation of a yeast pseudo DNA methyltransferase by deletion of a single amino acid.

Pinarbasi E et al. J Mol Biol 1996 Apr 12;257(4):804-13

PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.

Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704

PMID:25373780 - A genomic Multiprocess survey of machineries that control and link cell shape, microtubule organization, and cell-cycle progression.

Graml V et al. Dev Cell 2014 Oct 27;31(2):227-239

PMID:30715423 - Queuine links translational control in eukaryotes to a micronutrient from bacteria.

Müller M et al. Nucleic Acids Res 2019 Apr 23;47(7):3711-3727

PMID:7862522 - The fission yeast gene pmt1+ encodes a DNA methyltransferase homologue.

Wilkinson CR et al. Nucleic Acids Res 1995 Jan 25;23(2):203-10

PMID:24711368 - The Dnmt2 RNA methyltransferase homolog of Geobacter sulfurreducens specifically methylates tRNA-Glu.

Shanmugam R et al. Nucleic Acids Res 2014 Jun;42(10):6487-96

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:28208632 - Cross-Talk between Dnmt2-Dependent tRNA Methylation and Queuosine Modification.

Ehrenhofer-Murray AE Biomolecules 2017 Feb 10;7(1)

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.

Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7

PMID:23074192 - Pmt1, a Dnmt2 homolog in Schizosaccharomyces pombe, mediates tRNA methylation in response to nutrient signaling.

Becker M et al. Nucleic Acids Res 2012 Dec;40(22):11648-58

PMID:29892076 - Structural insights into the stimulation of S. pombe Dnmt2 catalytic efficiency by the tRNA nucleoside queuosine.

Johannsson S et al. Sci Rep 2018 Jun 11;8(1):8880

PMID:29259000 - Genes Important for Schizosaccharomyces pombe Meiosis Identified Through a Functional Genomics Screen.

Blyth J et al. Genetics 2018 Feb;208(2):589-603

PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.

Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105

PMID:16537923 - Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.

Todd BL et al. Mol Cell Biol 2006 Apr;26(7):2817-31

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.

Rodríguez-López M et al. Elife 2023 Oct 03;12

PMID:9628362 - Substitution of the conserved phenylalanine in the S-adenosyl-L-methionine binding site of M.MspI with tyrosine modifies the kinetic properties of the enzyme.

Pinarbasi E et al. Biol Chem 1998;379(4-5):591-4

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053