PomBase - protein coding gene - rpc10 (SPBC19C2.03) - DNA-directed RNA polymerase I, II and III subunit Rpc10 - The Schizosaccharomyces pombe genome database

ID	Name	InterPro name	DB name
PF03604	Zn_ribbon_RPAB4	RNAP_P/RPABC4	Pfam
SM00659	RPOLCX	RNAP_P/RPABC4	SMART
G3DSA:2.20.28.30:FF:000002			CATH-FunFam
G3DSA:2.20.28.30			CATH-Gene3D
SSF63393		RPABC4/Spt4	SUPERFAMILY
PTHR12056		RPABC4	PANTHER

References / Literature

PMID:9322754 - Gene organization and protein sequence of the small subunits of Schizosaccharomyces pombe RNA polymerase II.: Sakurai H et al. Gene 1997 Sep 01;196(1-2):165-74
PMID:11839823 - Formation of a carboxy-terminal domain phosphatase (Fcp1)/TFIIF/RNA polymerase II (pol II) complex in Schizosaccharomyces pombe involves direct interaction between Fcp1 and the Rpb4 subunit of pol II.: Kimura M et al. Mol Cell Biol 2002 Mar;22(5):1577-88
PMID:10648788 - Involvement of multiple subunit-subunit contacts in the assembly of RNA polymerase II.: Kimura M et al. Nucleic Acids Res 2000 Feb 15;28(4):952-9
PMID:15743411 - Studies of Schizosaccharomyces pombe TFIIE indicate conformational and functional changes in RNA polymerase II at transcription initiation.: Hayashi K et al. Genes Cells 2005 Mar;10(3):207-24
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.: Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:28476936 - Genome-wide screen for cell growth regulators in fission yeast.: Weston L et al. J Cell Sci 2017 Jun 15;130(12):2049-2055
PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.: Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399
PMID:9290054 - [Molecular cloning and characterization of cDNA of the rpc10+ gene encoding the smallest subunit of nuclear RNA polymerases of Schizosaccharomyces pombe].: Shpakovskiĭ GV et al. Bioorg Khim 1997 May;23(5):441-8
PMID:21511999 - Comparative functional genomics of the fission yeasts.: Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:39746995 - DSIF factor Spt5 coordinates transcription, maturation and exoribonucleolysis of RNA polymerase II transcripts.: Kuś K et al. Nat Commun 2025 Jan 02;16(1):10
PMID:9642054 - Two large subunits of the fission yeast RNA polymerase II provide platforms for the assembly of small subunits.: Ishiguro A et al. J Mol Biol 1998 Jun 19;279(4):703-12
PMID:15620689 - Glyceraldehyde-3-phosphate dehydrogenase and actin associate with RNA polymerase II and interact with its Rpb7 subunit.: Mitsuzawa H et al. FEBS Lett 2005 Jan 03;579(1):48-52
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.: Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.: Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:30282034 - Elongation/Termination Factor Exchange Mediated by PP1 Phosphatase Orchestrates Transcription Termination.: Kecman T et al. Cell Rep 2018 Oct 02;25(1):259-269.e5
PMID:33536435 - Conserved strategies of RNA polymerase I hibernation and activation.: Heiss FB et al. Nat Commun 2021 Feb 03;12(1):758
PMID:9548938 - Location of subunit-subunit contact sites on RNA polymerase II subunit 3 from the fission yeast Schizosaccharomyces pombe.: Yasui K et al. Biochemistry 1998 Apr 21;37(16):5542-8
PMID:25117315 - A potential protective role for thiamine in glucose-driven oxidative stress.: Palabiyik B et al. Genet Mol Res 2014 Jul 25;13(3):5582-93
PMID:19458260 - Schizosacharomyces pombe RNA polymerase II at 3.6-A resolution.: Spåhr H et al. Proc Natl Acad Sci U S A 2009 Jun 09;106(23):9185-90
PMID:16204182 - RNA Pol II subunit Rpb7 promotes centromeric transcription and RNAi-directed chromatin silencing.: Djupedal I et al. Genes Dev 2005 Oct 01;19(19):2301-6
PMID:26537787 - Targeting of SUMO substrates to a Cdc48-Ufd1-Npl4 segregase and STUbL pathway in fission yeast.: Køhler JB et al. Nat Commun 2015 Nov 05;6:8827
PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.: Strachan J et al. J Cell Sci 2023 Dec 01;136(23)
PMID:9325316 - RNA polymerase II subunits 2, 3, and 11 form a core subassembly with DNA binding activity.: Kimura M et al. J Biol Chem 1997 Oct 10;272(41):25851-5
PMID:11168400 - Intracellular contents and assembly states of all 12 subunits of the RNA polymerase II in the fission yeast Schizosaccharomyces pombe.: Kimura M et al. Eur J Biochem 2001 Feb;268(3):612-9
GO_REF:0000002 - Comments
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.: Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:28241144 - Mediator structure and rearrangements required for holoenzyme formation.: Tsai KL et al. Nature 2017 Apr 13;544(7649):196-201

protein coding gene - rpc10 (SPBC19C2.03) - DNA-directed RNA polymerase I, II and III subunit Rpc10

Gene summary

Annotation

PBO:0000445 - 2.7.7.6

GO biological process

GO:0006360 - transcription by RNA polymerase I

GO:0006366 - transcription by RNA polymerase II

GO:0006383 - transcription by RNA polymerase III

GO:0006362 - transcription elongation by RNA polymerase I

GO cellular component

GO:0005829 - cytosol

GO:0005730 - nucleolus

GO:0005634 - nucleus

GO:0005736 - RNA polymerase I complex

GO:0005665 - RNA polymerase II, core complex

GO:0005666 - RNA polymerase III complex

GO molecular function

GO:0003677 - DNA binding

GO:0003899 - DNA-directed RNA polymerase activity

GO:0008270 - zinc ion binding

Modification

MOD:01149 - sumoylated lysine

MOD:01148 - ubiquitinylated lysine

Multi-locus phenotype

FYPO:0007786 - elongated cell with cell cycle arrest at meiotic G2/MI transition

Qualitative gene expression

PomGeneEx:0000012 - RNA level decreased

Quantitative gene expression

PBO:0006310 - protein level

PBO:0011963 - RNA level

Single locus phenotype

FYPO:0000311 - inviable after spore germination with normal, unseptated germ tube morphology

FYPO:0002061 - inviable vegetative cell population

Taxonomic conservation

PBO:0011072 - conserved in archaea

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

Orthologs

References / Literature