protein coding gene - pat1 (SPBC19C2.05) - serine/threonine protein kinase Ran1/Pat1

Gene summary

Standard name

pat1

Systematic ID

SPBC19C2.05

Product

serine/threonine protein kinase Ran1/Pat1

Organism

Schizosaccharomyces pombe (fission yeast)

Synonyms

ran1

UniProt ID

P08092

ORFeome ID

40/40E07

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome II: 1682861..1684555 forward strand

Annotation

Protein features

Orthologs

• pat1 (SJAG_01311) Schizosaccharomyces japonicus
• VHS1 (YDR247W) Saccharomyces cerevisiae
• SKS1 (YPL026C) Saccharomyces cerevisiae

References / Literature

PMID:1989884 - S. pombe pac1+, whose overexpression inhibits sexual development, encodes a ribonuclease III-like RNase.

Iino Y et al. EMBO J 1991 Jan;10(1):221-6

PMID:21409593 - Regulation and role of an RNA-binding protein Msa2 in controlling the sexual differentiation of fission yeast.

Oowatari Y et al. Curr Genet 2011 Jun;57(3):191-200

PMID:23695164 - Cross-species protein interactome mapping reveals species-specific wiring of stress response pathways.

Das J et al. Sci Signal 2013 May 21;6(276):ra38

PMID:15238514 - Conserved and nonconserved proteins for meiotic DNA breakage and repair in yeasts.

Young JA et al. Genetics 2004 Jun;167(2):593-605

PMID:14665462 - Sla1, a Schizosaccharomyces pombe homolog of the human La protein, induces ectopic meiosis when its C terminus is truncated.

Tanabe K et al. Eukaryot Cell 2003 Dec;2(6):1274-87

PMID:22144909 - The fission yeast stress-responsive MAPK pathway promotes meiosis via the phosphorylation of Pol II CTD in response to environmental and feedback cues.

Sukegawa Y et al. PLoS Genet 2011 Dec;7(12):e1002387

PMID:23843742 - Quantitative control of protein S-palmitoylation regulates meiotic entry in fission yeast.

Zhang MM et al. PLoS Biol 2013 Jul;11(7):e1001597

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:27354705 - The S. pombe mRNA decapping complex recruits cofactors and an Edc1-like activator through a single dynamic surface.

Wurm JP et al. RNA 2016 Sep;22(9):1360-72

PMID:32513655 - Pdc2/Pat1 increases the range of decay factors and RNA bound by the Lsm1-7 complex.

Lobel JH et al. RNA 2020 Oct;26(10):1380-1388

PMID:11781565 - Feedback regulation of the MBF transcription factor by cyclin Cig2.

Ayté J et al. Nat Cell Biol 2001 Dec;3(12):1043-50

PMID:8945514 - Molecular mimicry in development: identification of ste11+ as a substrate and mei3+ as a pseudosubstrate inhibitor of ran1+ kinase.

Li P et al. Cell 1996 Nov 29;87(5):869-80

PMID:3357510 - A specific inhibitor of the ran1+ protein kinase regulates entry into meiosis in Schizosaccharomyces pombe.

McLeod M et al. Nature 1988 Apr 07;332(6164):509-14

PMID:8006074 - Analysis of the Schizosaccharomyces pombe cyclin puc1: evidence for a role in cell cycle exit.

Forsburg SL et al. J Cell Sci 1994 Mar;107 ( Pt 3):601-13

PMID:9062192 - Phosphorylation of RNA-binding protein controls cell cycle switch from mitotic to meiotic in fission yeast.

Watanabe Y et al. Nature 1997 Mar 13;386(6621):187-90

PMID:8832415 - The wis1 signal transduction pathway is required for expression of cAMP-repressed genes in fission yeast.

Stettler S et al. J Cell Sci 1996 Jul;109 ( Pt 7):1927-35

PMID:3870979 - ran1+ controls the transition from mitotic division to meiosis in fission yeast.

Beach D et al. Curr Genet 1985;10(4):297-311

PMID:29084823 - Phosphorylation of the RNA-binding protein Zfs1 modulates sexual differentiation in fission yeast.

Navarro FJ et al. J Cell Sci 2017 Dec 15;130(24):4144-4154

PMID:9799254 - Characterization of functional regions in the Schizosaccharomyces pombe mei3 developmental activator.

Wang W et al. Genetics 1998 Nov;150(3):1007-18

PMID:10521402 - Meiotic DNA replication checkpoint control in fission yeast.

Murakami H et al. Genes Dev 1999 Oct 01;13(19):2581-93

PMID:2328719 - The pat1 protein kinase controls transcription of the mating-type genes in fission yeast.

Nielsen O et al. EMBO J 1990 May;9(5):1401-6

PMID:23986474 - Mutation of a conserved residue enhances the sensitivity of analogue-sensitised kinases to generate a novel approach to the study of mitosis in fission yeast.

Tay YD et al. J Cell Sci 2013 Nov 01;126(Pt 21):5052-61

PMID:3034608 - The product of the mei3+ gene, expressed under control of the mating-type locus, induces meiosis and sporulation in fission yeast.

McLeod M et al. EMBO J 1987 Mar;6(3):729-36

PMID:7498766 - The role of cdc2 and other genes in meiosis in Schizosaccharomyces pombe.

Iino Y et al. Genetics 1995 Aug;140(4):1235-45

PMID:10996255 - Members of the Arabidopsis 14-3-3 gene family trans-complement two types of defects in fission yeast.

Kuromori T et al. Plant Sci 2000 Sep 08;158(1-2):155-161

PMID:25891897 - A single cyclin-CDK complex is sufficient for both mitotic and meiotic progression in fission yeast.

Gutiérrez-Escribano P et al. Nat Commun 2015 Apr 20;6:6871

PMID:10805744 - Cpc2, a fission yeast homologue of mammalian RACK1 protein, interacts with Ran1 (Pat1) kinase To regulate cell cycle progression and meiotic development.

McLeod M et al. Mol Cell Biol 2000 Jun;20(11):4016-27

PMID:21340088 - Microarray-based target identification using drug hypersensitive fission yeast expressing ORFeome.

Arita Y et al. Mol Biosyst 2011 May;7(5):1463-72

PMID:16550352 - A starvation-specific serine protease gene, isp6+, is involved in both autophagy and sexual development in Schizosaccharomyces pombe.

Nakashima A et al. Curr Genet 2006 Jun;49(6):403-13

PMID:24089141 - DNA intermediates of meiotic recombination in synchronous S. pombe at optimal temperature.

Hyppa RW et al. Nucleic Acids Res 2014 Jan;42(1):359-69

PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.

Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87

PMID:39476757 - Characterization of Ksg1 protein kinase-dependent phosphoproteome in the fission yeast S. pombe.

Cipak L et al. Biochem Biophys Res Commun 2024 Oct 25;736:150895

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.

Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323

PMID:15713656 - Constitutive activation of the fission yeast pheromone-responsive pathway induces ectopic meiosis and reveals ste11 as a mitogen-activated protein kinase target.

Kjaerulff S et al. Mol Cell Biol 2005 Mar;25(5):2045-59

PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.

Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399

GO_REF:0000051 - S. pombe keyword mapping

PMID:28476936 - Genome-wide screen for cell growth regulators in fission yeast.

Weston L et al. J Cell Sci 2017 Jun 15;130(12):2049-2055

PMID:17046992 - Fission yeast Tor2 promotes cell growth and represses cell differentiation.

Alvarez B et al. J Cell Sci 2006 Nov 01;119(Pt 21):4475-85

PMID:29330317 - tRNA production links nutrient conditions to the onset of sexual differentiation through the TORC1 pathway.

Otsubo Y et al. EMBO Rep 2018 Mar;19(3)

PMID:15837798 - Efficient formation of bipolar microtubule bundles requires microtubule-bound gamma-tubulin complexes.

Janson ME et al. J Cell Biol 2005 Apr 25;169(2):297-308

PMID:8557039 - Schizosaccharomyces pombe atf1+ encodes a transcription factor required for sexual development and entry into stationary phase.

Takeda T et al. EMBO J 1995 Dec 15;14(24):6193-208

PMID:1464317 - A new cdc gene required for S phase entry of Schizosaccharomyces pombe encodes a protein similar to the cdc 10+ and SWI4 gene products.

Tanaka K et al. EMBO J 1992 Dec;11(13):4923-32

PMID:7651414 - Two-step activation of meiosis by the mat1 locus in Schizosaccharomyces pombe.

Willer M et al. Mol Cell Biol 1995 Sep;15(9):4964-70

PMID:9671458 - An RNA binding protein negatively controlling differentiation in fission yeast.

Tsukahara K et al. Mol Cell Biol 1998 Aug;18(8):4488-98

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.

Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7

PMID:9745019 - ras1 and pat1 alleles interact to quantitatively and qualitatively alter conjugation in fission yeast.

Mach KE et al. Curr Genet 1998 Sep;34(3):172-82

PMID:22558440 - Cuf2 is a novel meiosis-specific regulatory factor of meiosis maturation.

Ioannoni R et al. PLoS One 2012;7(4):e36338

PMID:7909513 - A B-type cyclin negatively regulates conjugation via interacting with cell cycle 'start' genes in fission yeast.

Obara-Ishihara T et al. EMBO J 1994 Apr 15;13(8):1863-72

PMID:15992541 - The fission yeast homolog of the human transcription factor EAP30 blocks meiotic spindle pole body amplification.

Jin Y et al. Dev Cell 2005 Jul;9(1):63-73

PMID:3185514 - The role of sterility genes (ste and aff) in the initiation of sexual development in Schizosaccharomyces pombe.

Sipiczki M Mol Gen Genet 1988 Aug;213(2-3):529-34

PMID:7616961 - Rescue of the fission yeast snRNA synthesis mutant snm1 by overexpression of the double-strand-specific Pac1 ribonuclease.

Rotondo G et al. Mol Gen Genet 1995 Jun 25;247(6):698-708

PMID:1657594 - Interaction between ran1+ protein kinase and cAMP dependent protein kinase as negative regulators of fission yeast meiosis.

DeVoti J et al. EMBO J 1991 Dec;10(12):3759-68

PMID:25864229 - Mutants of Schizosaccharomyces pombe which sporulate in the haploid state.

Lino Y et al. Mol Gen Genet 1985;198(3):416-21

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:2840284 - The S.pombe mei2 gene encoding a crucial molecule for commitment to meiosis is under the regulation of cAMP.

Watanabe Y et al. EMBO J 1988 Mar;7(3):761-7

PMID:8144551 - Cloning of the pka1 gene encoding the catalytic subunit of the cAMP-dependent protein kinase in Schizosaccharomyces pombe.

Maeda T et al. J Biol Chem 1994 Apr 01;269(13):9632-7

PMID:8824587 - Conjugation, meiosis, and the osmotic stress response are regulated by Spc1 kinase through Atf1 transcription factor in fission yeast.

Shiozaki K et al. Genes Dev 1996 Sep 15;10(18):2276-88

PMID:9372444 - A zinc finger protein required for stationary phase viability in fission yeast.

Hao Z et al. J Cell Sci 1997 Oct;110 ( Pt 20):2557-66

PMID:30217891 - Physical basis for long-distance communication along meiotic chromosomes.

Fowler KR et al. Proc Natl Acad Sci U S A 2018 Oct 02;115(40):E9333-E9342

PMID:34851403 - Direct evaluation of cohesin-mediated sister kinetochore associations at meiosis I in fission yeast.

Nambu M et al. J Cell Sci 2022 Jan 01;135(1)

PMID:36370267 - SILAC-Based Proteomic Analysis of Meiosis in the Fission Yeast Schizosaccharomyces pombe.

Anrather D et al. Methods Mol Biol 2023;2603:19-29

PMID:11854402 - Essential role of MCM proteins in premeiotic DNA replication.

Lindner K et al. Mol Biol Cell 2002 Feb;13(2):435-44

PMID:20531409 - Global coordination of transcriptional control and mRNA decay during cellular differentiation.

Amorim MJ et al. Mol Syst Biol 2010 Jun 08;6:380

PMID:11818066 - 14-3-3 protein interferes with the binding of RNA to the phosphorylated form of fission yeast meiotic regulator Mei2p.

Sato M et al. Curr Biol 2002 Jan 22;12(2):141-5

PMID:10648609 - Novel WD-repeat protein Mip1p facilitates function of the meiotic regulator Mei2p in fission yeast.

Shinozaki-Yabana S et al. Mol Cell Biol 2000 Feb;20(4):1234-42

PMID:16787941 - The Schizosaccharomyces pombe septation initiation network (SIN) is required for spore formation in meiosis.

Krapp A et al. J Cell Sci 2006 Jul 15;119(Pt 14):2882-91

PMID:22487684 - ATP analog-sensitive Pat1 protein kinase for synchronous fission yeast meiosis at physiological temperature.

Cipak L et al. Cell Cycle 2012 Apr 15;11(8):1626-33

PMID:23738021 - A genome-wide screening of potential target genes to enhance the antifungal activity of micafungin in Schizosaccharomyces pombe.

Zhou X et al. PLoS One 2013;8(5):e65904

PMID:25375137 - Systematic analysis of the role of RNA-binding proteins in the regulation of RNA stability.

Hasan A et al. PLoS Genet 2014 Nov;10(11):e1004684

PMID:3830131 - Homology between the ran1+ gene of fission yeast and protein kinases.

McLeod M et al. EMBO J 1986 Dec 20;5(13):3665-71

PMID:27984744 - Survival in Quiescence Requires the Euchromatic Deployment of Clr4/SUV39H by Argonaute-Associated Small RNAs.

Joh RI et al. Mol Cell 2016 Dec 15;64(6):1088-1101

PMID:19279143 - Role of the RNA-binding protein Nrd1 and Pmk1 mitogen-activated protein kinase in the regulation of myosin mRNA stability in fission yeast.

Satoh R et al. Mol Biol Cell 2009 May;20(9):2473-85

PMID:16478992 - Requirement of fission yeast Cid14 in polyadenylation of rRNAs.

Win TZ et al. Mol Cell Biol 2006 Mar;26(5):1710-21

PMID:31690658 - Pat1 activates late steps in mRNA decay by multiple mechanisms.

Lobel JH et al. Proc Natl Acad Sci U S A 2019 Nov 19;116(47):23512-23517

PMID:3058333 - Multiple phosphorylated forms of the product of the fission yeast cell division cycle gene cdc2+.

Potashkin JA et al. Curr Genet 1988 Sep;14(3):235-40

PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.

Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105

PMID:12727894 - Monopolar spindle attachment of sister chromatids is ensured by two distinct mechanisms at the first meiotic division in fission yeast.

Yamamoto A et al. EMBO J 2003 May 01;22(9):2284-96

PMID:10392445 - Eleven novel sep genes of Schizosaccharomyces pombe required for efficient cell separation and sexual differentiation.

Grallert A et al. Yeast 1999 Jun 15;15(8):669-86

PMID:29432178 - General amino acid control in fission yeast is regulated by a nonconserved transcription factor, with functions analogous to Gcn4/Atf4.

Duncan CDS et al. Proc Natl Acad Sci U S A 2018 Feb 20;115(8):E1829-E1838

PMID:41298081 - Gamete fusion triggers cytosolic functions and P-body recruitment of the RNA-binding protein Mei2 to drive fission yeast zygotic development.

Araoyinbo A et al. Genes Dev 2025 Nov 26;

PMID:8001162 - Mutations in cyr1 and pat1 reveal pheromone-induced G1 arrest in the fission yeast Schizosaccharomyces pombe.

Davey J et al. Curr Genet 1994 Aug;26(2):105-12

PMID:8536311 - Schizosaccharomyces pombe pac2+ controls the onset of sexual development via a pathway independent of the cAMP cascade.

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PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

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PMID:8824588 - The Atf1 transcription factor is a target for the Sty1 stress-activated MAP kinase pathway in fission yeast.

Wilkinson MG et al. Genes Dev 1996 Sep 15;10(18):2289-301

PMID:1878997 - Synchronized meiosis and recombination in fission yeast: observations with pat1-114 diploid cells.

Bähler J et al. Curr Genet 1991 Jun;19(6):445-51

PMID:10835379 - Schizosaccharomyces pombe Ste7p is required for both promotion and withholding of the entry to meiosis.

Matsuyama A et al. Genetics 2000 Jun;155(2):539-49

PMID:15298676 - Meiosis induced by inactivation of Pat1 kinase proceeds with aberrant nuclear positioning of centromeres in the fission yeast Schizosaccharomyces pombe.

Chikashige Y et al. Genes Cells 2004 Aug;9(8):671-84

PMID:23755176 - Proper microtubule structure is vital for timely progression through meiosis in fission yeast.

Yamashita A et al. PLoS One 2013;8(6):e65082

PMID:8381348 - A Schizosaccharomyces pombe gene that promotes sexual differentiation encodes a helix-loop-helix protein with homology to MyoD.

Benton BK et al. EMBO J 1993 Jan;12(1):135-43

PMID:9201720 - Ran1 functions to control the Cdc10/Sct1 complex through Puc1.

Caligiuri M et al. Mol Biol Cell 1997 Jun;8(6):1117-28

PMID:9447985 - Novel factor highly conserved among eukaryotes controls sexual development in fission yeast.

Okazaki N et al. Mol Cell Biol 1998 Feb;18(2):887-95