protein coding gene - sre1 (SPBC19C2.09) - DNA-binding transcription factor, sterol regulatory element binding protein Sre1

Gene summary

Standard name

sre1

Systematic ID

SPBC19C2.09

Product

DNA-binding transcription factor, sterol regulatory element binding protein Sre1

Organism

Schizosaccharomyces pombe (fission yeast)

UniProt ID

Q9UUD1

ORFeome ID

39/39A03

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome II: 1691394..1694691 forward strand

Annotation

Protein features

Orthologs

• SREBF1 (HGNC:11289) Homo sapiens
• SREBF2 (HGNC:11290) Homo sapiens
• sre1 (SJAG_01307) Schizosaccharomyces japonicus

References / Literature

PMID:27053105 - Mga2 Transcription Factor Regulates an Oxygen-responsive Lipid Homeostasis Pathway in Fission Yeast.

Burr R et al. J Biol Chem 2016 Jun 03;291(23):12171-83

PMID:15797383 - SREBP pathway responds to sterols and functions as an oxygen sensor in fission yeast.

Hughes AL et al. Cell 2005 Mar 25;120(6):831-42

PMID:27811944 - Complex structure of the fission yeast SREBP-SCAP binding domains reveals an oligomeric organization.

Gong X et al. Cell Res 2016 Nov;26(11):1197-1211

PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.

Halova L et al. Open Biol 2021 Apr;11(4):200405

PMID:27984744 - Survival in Quiescence Requires the Euchromatic Deployment of Clr4/SUV39H by Argonaute-Associated Small RNAs.

Joh RI et al. Mol Cell 2016 Dec 15;64(6):1088-1101

PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.

Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704

PMID:29996109 - Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe.

Swaffer MP et al. Cell Rep 2018 Jul 10;24(2):503-514

GO_REF:0000051 - S. pombe keyword mapping

PMID:28202541 - Coordinate Regulation of Yeast Sterol Regulatory Element-binding Protein (SREBP) and Mga2 Transcription Factors.

Burr R et al. J Biol Chem 2017 Mar 31;292(13):5311-5324

PMID:21481773 - The hypoxic regulator of sterol synthesis nro1 is a nuclear import adaptor.

Yeh TL et al. Structure 2011 Apr 13;19(4):503-14

PMID:26537787 - Targeting of SUMO substrates to a Cdc48-Ufd1-Npl4 segregase and STUbL pathway in fission yeast.

Køhler JB et al. Nat Commun 2015 Nov 05;6:8827

GO_REF:0000033 - Annotation inferences using phylogenetic trees

PMID:26412298 - A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.

Beckley JR et al. Mol Cell Proteomics 2015 Dec;14(12):3132-41

PMID:27343236 - Restriction of Retrotransposon Mobilization in Schizosaccharomyces pombe by Transcriptional Silencing and Higher-Order Chromatin Organization.

Murton HE et al. Genetics 2016 Aug;203(4):1669-78

PMID:21504829 - Yeast SREBP cleavage activation requires the Golgi Dsc E3 ligase complex.

Stewart EV et al. Mol Cell 2011 Apr 22;42(2):160-71

PMID:22017871 - Regulation of the Sre1 hypoxic transcription factor by oxygen-dependent control of DNA binding.

Lee CY et al. Mol Cell 2011 Oct 21;44(2):225-34

PMID:22235339 - The S. pombe histone H2A dioxygenase Ofd2 regulates gene expression during hypoxia.

Lando D et al. PLoS One 2012;7(1):e29765

PMID:23729666 - Structural requirements for sterol regulatory element-binding protein (SREBP) cleavage in fission yeast.

Chong R et al. J Biol Chem 2013 Jul 12;288(28):20351-60

PMID:24327658 - Casein kinase 1 regulates sterol regulatory element-binding protein (SREBP) to control sterol homeostasis.

Brookheart RT et al. J Biol Chem 2014 Jan 31;289(5):2725-35

PMID:27655872 - A Golgi rhomboid protease Rbd2 recruits Cdc48 to cleave yeast SREBP.

Hwang J et al. EMBO J 2016 Nov 02;35(21):2332-2349

PMID:22633491 - Mapping N-glycosylation sites across seven evolutionarily distant species reveals a divergent substrate proteome despite a common core machinery.

Zielinska DF et al. Mol Cell 2012 May 25;46(4):542-8

PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.

Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87

PMID:25918164 - Endoplasmic Reticulum Exit of Golgi-resident Defective for SREBP Cleavage (Dsc) E3 Ligase Complex Requires Its Activity.

Raychaudhuri S et al. J Biol Chem 2015 Jun 05;290(23):14430-40

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:22086920 - Yeast sterol regulatory element-binding protein (SREBP) cleavage requires Cdc48 and Dsc5, a ubiquitin regulatory X domain-containing subunit of the Golgi Dsc E3 ligase.

Stewart EV et al. J Biol Chem 2012 Jan 02;287(1):672-681

PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.

Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323

PMID:28821619 - Dsc E3 ligase localization to the Golgi requires the ATPase Cdc48 and cofactor Ufd1 for activation of sterol regulatory element-binding protein in fission yeast.

Burr R et al. J Biol Chem 2017 Sep 29;292(39):16333-16350

PMID:33260998 - High-Throughput Flow Cytometry Combined with Genetic Analysis Brings New Insights into the Understanding of Chromatin Regulation of Cellular Quiescence.

Zahedi Y et al. Int J Mol Sci 2020 Nov 27;21(23)

PMID:26545776 - Identification of Rbd2 as a candidate protease for sterol regulatory element binding protein (SREBP) cleavage in fission yeast.

Kim J et al. Biochem Biophys Res Commun 2015 Dec 25;468(4):606-10

PMID:36794724 - Cellular responses to long-term phosphate starvation of fission yeast: Maf1 determines fate choice between quiescence and death associated with aberrant tRNA biogenesis.

Garg A et al. Nucleic Acids Res 2023 Apr 24;51(7):3094-3115

PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.

Rodríguez-López M et al. Elife 2023 Oct 03;12

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:25771684 - Structure of the WD40 domain of SCAP from fission yeast reveals the molecular basis for SREBP recognition.

Gong X et al. Cell Res 2015 Apr;25(4):401-11

PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.

Strachan J et al. J Cell Sci 2023 Dec 01;136(23)

PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.

Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105

PMID:16537923 - Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.

Todd BL et al. Mol Cell Biol 2006 Apr;26(7):2817-31

PMID:21712547 - Mitotic substrates of the kinase aurora with roles in chromatin regulation identified through quantitative phosphoproteomics of fission yeast.

Koch A et al. Sci Signal 2011 Jun 28;4(179):rs6

PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.

Skribbe M et al. Mol Cell 2025 Feb 19;

PMID:9745019 - ras1 and pat1 alleles interact to quantitatively and qualitatively alter conjugation in fission yeast.

Mach KE et al. Curr Genet 1998 Sep;34(3):172-82

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:29083304 - Prolyl dihydroxylation of unassembled uS12/Rps23 regulates fungal hypoxic adaptation.

Clasen SJ et al. Elife 2017 Oct 30;6

PMID:11790253 - Computational prediction of membrane-tethered transcription factors.

Zupicich J et al. Genome Biol 2001;2(12):RESEARCH0050

PMID:18418381 - Oxygen-regulated degradation of fission yeast SREBP by Ofd1, a prolyl hydroxylase family member.

Hughes BT et al. EMBO J 2008 May 21;27(10):1491-501

PMID:11152613 - Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes.

Krogh A et al. J Mol Biol 2001 Jan 19;305(3):567-80

PMID:29259000 - Genes Important for Schizosaccharomyces pombe Meiosis Identified Through a Functional Genomics Screen.

Blyth J et al. Genetics 2018 Feb;208(2):589-603

PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.

Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7

PMID:32053662 - AMPKα Subunit Ssp2 and Glycogen Synthase Kinases Gsk3/Gsk31 are involved in regulation of sterol regulatory element-binding protein (SREBP) activity in fission yeast.

Miao H et al. PLoS One 2020;15(2):e0228845

PMID:19520858 - Degradation of sterol regulatory element-binding protein precursor requires the endoplasmic reticulum-associated degradation components Ubc7 and Hrd1 in fission yeast.

Hughes BT et al. J Biol Chem 2009 Jul 31;284(31):20512-21

PMID:23760507 - Subunit architecture of the Golgi Dsc E3 ligase required for sterol regulatory element-binding protein (SREBP) cleavage in fission yeast.

Lloyd SJ et al. J Biol Chem 2013 Jul 19;288(29):21043-21054

PMID:28281664 - Genetic interactions and functional analyses of the fission yeast gsk3 and amk2 single and double mutants defective in TORC1-dependent processes.

Rallis C et al. Sci Rep 2017 Mar 10;7:44257

PMID:30321377 - Proteomic profiling and functional characterization of post-translational modifications of the fission yeast RNA exosome.

Telekawa C et al. Nucleic Acids Res 2018 Nov 30;46(21):11169-11183

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs

PMID:18276645 - Oxygen-dependent, alternative promoter controls translation of tco1+ in fission yeast.

Sehgal A et al. Nucleic Acids Res 2008 Apr;36(6):2024-31