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protein coding gene - mdm34 (SPBC19C2.11c) - ERMES complex subunit, membrane tether and lipid transfer protein Mdm34

Gene summary

Standard name
mdm34
Systematic ID
SPBC19C2.11c
Product
ERMES complex subunit, membrane tether and lipid transfer protein Mdm34
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
Q9UUC9
ORFeome ID
21/21B01
Characterisation status
biological role inferred
Feature type
mRNA gene
Genomic location
chromosome II: 1697447..1699237 reverse strand

Annotation

GO biological process

GO:0120010 - intermembrane phospholipid transfer

References:

GO:0007006 - mitochondrial membrane organization

References:

GO:1990456 - mitochondrion-endoplasmic reticulum membrane tethering

References:

GO cellular component

GO:0032865 - ERMES complex

References:

GO:0044233 - mitochondria-associated endoplasmic reticulum membrane contact site

References:

GO:0005739 - mitochondrion

References:

GO molecular function

GO:0008289 - lipid binding

References:

GO:0140474 - mitochondrion-endoplasmic reticulum membrane tether activity

References:

GO:0120014 - phospholipid transfer activity

References:

Modification

MOD:00047 - O-phospho-L-threonine

References:

MOD:01148 - ubiquitinylated lysine

References:

Qualitative gene expression

PomGeneEx:0000019 - protein level decreased

References:

PomGeneEx:0000018 - protein level increased

References:

PomGeneEx:0000011 - RNA level increased

References:

Quantitative gene expression

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0002187 - inviable normal volume spheroid vegetative cell

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011063 - conserved in fungi only

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF26545Mdm34_NMDM34_NPFAM
cd21673SMP_Mdm34CDD
PS51847SMPSMP_LBDPROSITE_PROFILES
PTHR28185MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 34MDM34PANTHER
MF_03105Mdm34MDM34HAMAP

Orthologs

References / Literature

GO_REF:0000111 - Gene Ontology annotations Inferred by Curator (IC) using at least one Inferred by Sequence Similarity (ISS) annotation to support the inference
PMID:26412298 - A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.
Beckley JR et al. Mol Cell Proteomics 2015 Dec;14(12):3132-41
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:29432178 - General amino acid control in fission yeast is regulated by a nonconserved transcription factor, with functions analogous to Gcn4/Atf4.
Duncan CDS et al. Proc Natl Acad Sci U S A 2018 Feb 20;115(8):E1829-E1838
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.
Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399
PMID:30824696 - Systematic analysis reveals the prevalence and principles of bypassable gene essentiality.
Li J et al. Nat Commun 2019 Mar 01;10(1):1002
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:33483504 - Emr1 regulates the number of foci of the endoplasmic reticulum-mitochondria encounter structure complex.
Rasul F et al. Nat Commun 2021 Jan 22;12(1):521
PMID:40124504 - Ltc1 localization by EMC regulates cell membrane fluidity to facilitate membrane protein biogenesis.
Berraquero M et al. iScience 2025 Mar 21;28(3):112096
PMID:29279306 - Structure-function insights into direct lipid transfer between membranes by Mmm1-Mdm12 of ERMES.
Kawano S et al. J Cell Biol 2018 Mar 05;217(3):959-974
GO_REF:0000002 - Comments
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:27984744 - Survival in Quiescence Requires the Euchromatic Deployment of Clr4/SUV39H by Argonaute-Associated Small RNAs.
Joh RI et al. Mol Cell 2016 Dec 15;64(6):1088-1101
PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.
Strachan J et al. J Cell Sci 2023 Dec 01;136(23)