protein coding gene - cyr1 (SPBC19C7.03) - adenylate cyclase

Gene summary

Standard name

cyr1

Systematic ID

SPBC19C7.03

Product

adenylate cyclase

Organism

Schizosaccharomyces pombe (fission yeast)

Synonyms

git2

UniProt ID

P14605

ORFeome ID

41/41A12

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome II: 2819802..2825220 forward strand

Annotation

Protein features

Orthologs

• cyr1 (SJAG_01254) Schizosaccharomyces japonicus
• CYR1 (YJL005W) Saccharomyces cerevisiae

References / Literature

PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.

Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87

GO_REF:0000051 - S. pombe keyword mapping

PMID:10835385 - Loss of Rhb1, a Rheb-related GTPase in fission yeast, causes growth arrest with a terminal phenotype similar to that caused by nitrogen starvation.

Mach KE et al. Genetics 2000 Jun;155(2):611-22

PMID:2682634 - The adenylyl cyclase gene from Schizosaccharomyces pombe.

Young D et al. Proc Natl Acad Sci U S A 1989 Oct;86(20):7989-93

PMID:27756188 - cAMP-dependent protein kinase involves calcium tolerance through the regulation of Prz1 in Schizosaccharomyces pombe.

Matsuo Y et al. Biosci Biotechnol Biochem 2017 Feb;81(2):231-241

PMID:19542312 - Functional genomics of adhesion, invasion, and mycelial formation in Schizosaccharomyces pombe.

Dodgson J et al. Eukaryot Cell 2009 Aug;8(8):1298-306

PMID:2172964 - Adenylyl cyclase is dispensable for vegetative cell growth in the fission yeast Schizosaccharomyces pombe.

Maeda T et al. Proc Natl Acad Sci U S A 1990 Oct;87(20):7814-8

PMID:38889144 - Cytoplasmic fluidization contributes to breaking spore dormancy in fission yeast.

Sakai K et al. Proc Natl Acad Sci U S A 2024 Jun 25;121(26):e2405553121

PMID:1550959 - Genetic and biochemical analysis of the adenylyl cyclase-associated protein, cap, in Schizosaccharomyces pombe.

Kawamukai M et al. Mol Biol Cell 1992 Feb;3(2):167-80

PMID:15166138 - A novel gene, msa1, inhibits sexual differentiation in Schizosaccharomyces pombe.

Jeong HT et al. Genetics 2004 May;167(1):77-91

PMID:20634885 - TOR and PKA pathways synergize at the level of the Ste11 transcription factor to prevent mating and meiosis in fission yeast.

Valbuena N et al. PLoS One 2010 Jul 09;5(7):e11514

PMID:11950884 - Different mechanisms of cell polarisation in vegetative and shmooing growth in fission yeast.

Niccoli T et al. J Cell Sci 2002 Apr 15;115(Pt 8):1651-62

PMID:12715160 - The phospholipase B homolog Plb1 is a mediator of osmotic stress response and of nutrient-dependent repression of sexual differentiation in the fission yeast Schizosaccharomyces pombe.

Yang P et al. Mol Genet Genomics 2003 Apr;269(1):116-25

PMID:23843946 - The role of the RACK1 ortholog Cpc2p in modulating pheromone-induced cell cycle arrest in fission yeast.

Mos M et al. PLoS One 2013;8(7):e65927

PMID:8557039 - Schizosaccharomyces pombe atf1+ encodes a transcription factor required for sexual development and entry into stationary phase.

Takeda T et al. EMBO J 1995 Dec 15;14(24):6193-208

PMID:36112198 - Synergistic roles of the phospholipase B homolog Plb1 and the cAMP-dependent protein kinase Pka1 in the hypertonic stress response of Schizosaccharomyces pombe.

Matsuo Y et al. Curr Genet 2022 Dec;68(5-6):661-674

PMID:10805744 - Cpc2, a fission yeast homologue of mammalian RACK1 protein, interacts with Ran1 (Pat1) kinase To regulate cell cycle progression and meiotic development.

McLeod M et al. Mol Cell Biol 2000 Jun;20(11):4016-27

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.

Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:30301783 - The RHEB-mTOR axis regulates expression of Tf2 transposons in fission yeast.

Nakase Y et al. J Cell Sci 2018 Nov 21;131(22)

PMID:39476757 - Characterization of Ksg1 protein kinase-dependent phosphoproteome in the fission yeast S. pombe.

Cipak L et al. Biochem Biophys Res Commun 2024 Oct 25;736:150895

PMID:2178979 - Adenylyl cyclase activity of the fission yeast Schizosaccharomyces pombe is not regulated by guanyl nucleotides.

Engelberg D et al. FEBS Lett 1990 Feb 26;261(2):413-8

PMID:31562247 - Glucose starvation induces mitochondrial fragmentation depending on the dynamin GTPase Dnm1/Drp1 in fission yeast.

Zheng F et al. J Biol Chem 2019 Nov 22;294(47):17725-17734

PMID:11739717 - Protein kinase A regulates sexual development and gluconeogenesis through phosphorylation of the Zn finger transcriptional activator Rst2p in fission yeast.

Higuchi T et al. Mol Cell Biol 2002 Jan;22(1):1-11

PMID:1849107 - Glucose repression of transcription of the Schizosaccharomyces pombe fbp1 gene occurs by a cAMP signaling pathway.

Hoffman CS et al. Genes Dev 1991 Apr;5(4):561-71

PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.

Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963

PMID:25590601 - Fission yeast Ryh1 GTPase activates TOR Complex 2 in response to glucose.

Hatano T et al. Cell Cycle 2015;14(6):848-56

PMID:11014802 - Glucose monitoring in fission yeast via the Gpa2 galpha, the git5 Gbeta and the git3 putative glucose receptor.

Welton RM et al. Genetics 2000 Oct;156(2):513-21

PMID:15189983 - Suppressors of an adenylate cyclase deletion in the fission yeast Schizosaccharomyces pombe.

Stiefel J et al. Eukaryot Cell 2004 Jun;3(3):610-9

PMID:24297439 - Sck1 negatively regulates Gpa2-mediated glucose signaling in Schizosaccharomyces pombe.

Mudge DK et al. Eukaryot Cell 2014 Feb;13(2):202-8

PMID:15831585 - Direct activation of fission yeast adenylate cyclase by the Gpa2 Galpha of the glucose signaling pathway.

Ivey FD et al. Proc Natl Acad Sci U S A 2005 Apr 26;102(17):6108-13

PMID:18430926 - Schizosaccharomyces pombe Hsp90/Git10 is required for glucose/cAMP signaling.

Alaamery MA et al. Genetics 2008 Apr;178(4):1927-36

PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36

PMID:26443240 - PKA antagonizes CLASP-dependent microtubule stabilization to re-localize Pom1 and buffer cell size upon glucose limitation.

Kelkar M et al. Nat Commun 2015 Oct 07;6:8445

PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.

Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105

PMID:7498728 - sck1, a high copy number suppressor of defects in the cAMP-dependent protein kinase pathway in fission yeast, encodes a protein homologous to the Saccharomyces cerevisiae SCH9 kinase.

Jin M et al. Genetics 1995 Jun;140(2):457-67

PMID:8227198 - Six git genes encode a glucose-induced adenylate cyclase activation pathway in the fission yeast Schizosaccharomyces pombe.

Byrne SM et al. J Cell Sci 1993 Aug;105 ( Pt 4)(0 4):1095-100

PMID:30824696 - Systematic analysis reveals the prevalence and principles of bypassable gene essentiality.

Li J et al. Nat Commun 2019 Mar 01;10(1):1002

PMID:9535817 - Isolation and characterization of an invertase and its repressor genes from Schizosaccharomyces pombe.

Tanaka N et al. Biochem Biophys Res Commun 1998 Apr 07;245(1):246-53

PMID:9372444 - A zinc finger protein required for stationary phase viability in fission yeast.

Hao Z et al. J Cell Sci 1997 Oct;110 ( Pt 20):2557-66

PMID:8001162 - Mutations in cyr1 and pat1 reveal pheromone-induced G1 arrest in the fission yeast Schizosaccharomyces pombe.

Davey J et al. Curr Genet 1994 Aug;26(2):105-12

PMID:9372449 - Onset of gluconate-H+ symport in Schizosaccharomyces pombe is regulated by the kinases Wis1 and Pka1, and requires the gti1+ gene product.

Caspari T J Cell Sci 1997 Oct;110 ( Pt 20):2599-608

PMID:11180454 - The cyclic AMP/PKA signal pathway is required for initiation of spore germination in Schizosaccharomyces pombe.

Hatanaka M et al. Yeast 2001 Feb;18(3):207-17

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:12456004 - Schizosaccharomyces pombe Git7p, a member of the Saccharomyces cerevisiae Sgtlp family, is required for glucose and cyclic AMP signaling, cell wall integrity, and septation.

Schadick K et al. Eukaryot Cell 2002 Aug;1(4):558-67

PMID:30973898 - Mal3 is a multi-copy suppressor of the sensitivity to microtubule-depolymerizing drugs and chromosome mis-segregation in a fission yeast pka1 mutant.

Tanabe T et al. PLoS One 2019;14(4):e0214803

PMID:18621924 - Regulation of the subcellular localization of cyclic AMP-dependent protein kinase in response to physiological stresses and sexual differentiation in the fission yeast Schizosaccharomyces pombe.

Matsuo Y et al. Eukaryot Cell 2008 Sep;7(9):1450-9

GO_REF:0000033 - Annotation inferences using phylogenetic trees

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:38598031 - Pps1, phosphatidylserine synthase, regulates the salt stress response in Schizosaccharomyces pombe.

Naozuka G et al. Mol Genet Genomics 2024 Apr 10;299(1):43

PMID:16273369 - Moc3, a novel Zn finger type protein involved in sexual development, ascus formation, and stress response of Schizosaccharomyces pombe.

Goldar MM et al. Curr Genet 2005 Dec;48(6):345-55

PMID:2668944 - Adenylate cyclases in yeast: a comparison of the genes from Schizosaccharomyces pombe and Saccharomyces cerevisiae.

Yamawaki-Kataoka Y et al. Proc Natl Acad Sci U S A 1989 Aug;86(15):5693-7

PMID:20139237 - Activated alleles of the Schizosaccharomyces pombe gpa2+ Galpha gene identify residues involved in GDP-GTP exchange.

Ivey FD et al. Eukaryot Cell 2010 Apr;9(4):626-33

PMID:21118717 - Use of a Schizosaccharomyces pombe PKA-repressible reporter to study cGMP metabolising phosphodiesterases.

Demirbas D et al. Cell Signal 2011 Mar;23(3):594-601

PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.

Rodríguez-López M et al. Elife 2023 Oct 03;12

PMID:8832415 - The wis1 signal transduction pathway is required for expression of cAMP-repressed genes in fission yeast.

Stettler S et al. J Cell Sci 1996 Jul;109 ( Pt 7):1927-35

PMID:1657709 - Schizosaccharomyces pombe ste11+ encodes a transcription factor with an HMG motif that is a critical regulator of sexual development.

Sugimoto A et al. Genes Dev 1991 Nov;5(11):1990-9

PMID:25552606 - Identification of new players in cell division, DNA damage response, and morphogenesis through construction of Schizosaccharomyces pombe deletion strains.

Chen JS et al. G3 (Bethesda) 2014 Dec 31;5(3):361-70

PMID:11238401 - The git5 Gbeta and git11 Ggamma form an atypical Gbetagamma dimer acting in the fission yeast glucose/cAMP pathway.

Landry S et al. Genetics 2001 Mar;157(3):1159-68

PMID:35171902 - The cAMP signaling pathway regulates Epe1 protein levels and heterochromatin assembly.

Bao K et al. PLoS Genet 2022 Feb;18(2):e1010049

PMID:8314086 - The fission yeast mating pheromone P-factor: its molecular structure, gene structure, and ability to induce gene expression and G1 arrest in the mating partner.

Imai Y et al. Genes Dev 1994 Feb 01;8(3):328-38

PMID:9614176 - Cyclin B proteolysis and the cyclin-dependent kinase inhibitor rum1p are required for pheromone-induced G1 arrest in fission yeast.

Stern B et al. Mol Biol Cell 1998 Jun;9(6):1309-21

PMID:11554925 - The RGS domain-containing fission yeast protein, Rgs1p, regulates pheromone signalling and is required for mating.

Pereira PS et al. Genes Cells 2001 Sep;6(9):789-802

PMID:1863602 - Genetic and biochemical analysis of the adenylyl cyclase of Schizosaccharomyces pombe.

Kawamukai M et al. Cell Regul 1991 Feb;2(2):155-64

PMID:16489217 - Schizosaccharomyces pombe Git1 is a C2-domain protein required for glucose activation of adenylate cyclase.

Kao RS et al. Genetics 2006 May;173(1):49-61

PMID:15925945 - Direct activation of fission yeast adenylyl cyclase by heterotrimeric G protein gpa2.

Ogihara H et al. Kobe J Med Sci 2004;50(3-4):111-21

PMID:29996109 - Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe.

Swaffer MP et al. Cell Rep 2018 Jul 10;24(2):503-514

PMID:8832414 - The Schizosaccharomyces pombe pyp1 protein tyrosine phosphatase negatively regulates nutrient monitoring pathways.

Santo PD et al. J Cell Sci 1996 Jul;109 ( Pt 7)(0 7):1919-1925

PMID:21712547 - Mitotic substrates of the kinase aurora with roles in chromatin regulation identified through quantitative phosphoproteomics of fission yeast.

Koch A et al. Sci Signal 2011 Jun 28;4(179):rs6

GO_REF:0000002 - Comments

PMID:9191271 - Isolation of yeast mutants hypersensitive to mating pheromones.

Davis K et al. Biochem Soc Trans 1997 May;25(2):227S

PMID:36358992 - Multi-Layered Regulations on the Chromatin Architectures: Establishing the Tight and Specific Responses of Fission Yeast fbp1 Gene Transcription.

Asada R et al. Biomolecules 2022 Nov 05;12(11)

PMID:2157626 - Isolation and characterization of mutants constitutive for expression of the fbp1 gene of Schizosaccharomyces pombe.

Hoffman CS et al. Genetics 1990 Apr;124(4):807-16

PMID:32441227 - Glucose limitation and pka1 deletion rescue aberrant mitotic spindle formation induced by Mal3 overexpression in Schizosaccharomyces pombe .

Tanabe T et al. Biosci Biotechnol Biochem 2020 Aug;84(8):1667-1680

PMID:16143612 - Schizosaccharomyces pombe adenylate cyclase suppressor mutations suggest a role for cAMP phosphodiesterase regulation in feedback control of glucose/cAMP signaling.

Wang L et al. Genetics 2005 Dec;171(4):1523-33

PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.

Halova L et al. Open Biol 2021 Apr;11(4):200405

PMID:10395922 - Isolation of a novel gene, moc2, encoding a putative RNA helicase as a suppressor of sterile strains in Schizosaccharomyces pombe.

Kawamukai M Biochim Biophys Acta 1999 Jul 07;1446(1-2):93-101

PMID:31030285 - CoQ 10 production in Schizosaccharomyces pombe is increased by reduction of glucose levels or deletion of pka1.

Nishida I et al. Appl Microbiol Biotechnol 2019 Jun;103(12):4899-4915

PMID:7565608 - Schizosaccharomyces pombe rds1, an adenine-repressible gene regulated by glucose, ammonium, phosphate, carbon dioxide and temperature.

Ludin KM et al. Mol Gen Genet 1995 Aug 30;248(4):439-45

PMID:8001792 - Glucose repression of fbp1 transcription of Schizosaccharomyces pombe is partially regulated by adenylate cyclase activation by a G protein alpha subunit encoded by gpa2 (git8).

Nocero M et al. Genetics 1994 Sep;138(1):39-45

PMID:35286199 - Mitotic spindle formation in the absence of Polo kinase.

Kim J et al. Proc Natl Acad Sci U S A 2022 Mar 22;119(12):e2114429119

PMID:9264466 - Distinct subunit functions and cell cycle regulated phosphorylation of 20S APC/cyclosome required for anaphase in fission yeast.

Yamada H et al. J Cell Sci 1997 Aug;110 ( Pt 15):1793-804