PomBase home

protein coding gene - sen34 (SPBC19C7.07c) - tRNA-splicing endonuclease catalytic subunit Sen34

Gene summary

Standard name
sen34
Systematic ID
SPBC19C7.07c
Product
tRNA-splicing endonuclease catalytic subunit Sen34
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
O60156
ORFeome ID
11/11C07
Characterisation status
biological role inferred
Feature type
mRNA gene
Genomic location
chromosome II: 2833988..2835032 reverse strand

Annotation

PBO:0004228 - 3.1.27.9

Disease association

MONDO:0012891 - pontocerebellar hypoplasia type 2C

References:

GO biological process

GO:0000379 - tRNA-type intron splice site recognition and cleavage

References:

GO cellular component

GO:0032473 - cytoplasmic side of mitochondrial outer membrane

References:

GO:0000214 - tRNA-intron endonuclease complex

References:

GO molecular function

GO:0000213 - tRNA-intron lyase activity

References:

Qualitative gene expression

PomGeneEx:0000012 - RNA level decreased

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0000951 - inviable small vegetative cell

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

Taxonomic conservation

PBO:0011072 - conserved in archaea

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF01974tRNA_int_endotRNA_intron_Endonuc_cat-likePfam
PF26577TSEN34_NTSEN34_NPfam
cd22363tRNA-intron_lyase_CtRNA_intron_Endonuc_cat-likeCDD
G3DSA:3.40.1350.10:FF:000008CATH-FunFam
G3DSA:3.40.1350.10tRNA_endonuc-like_dom_sfCATH-Gene3D
SSF53032tRNA_intron_Endo_cat-like_sfSUPERFAMILY
PTHR13070PANTHER
PIRSF017250tRNA_splic_SEN34TSEN34PIRSF
TIGR00324endAtRNA_splicNCBIFAM

Orthologs

References / Literature

PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:30228203 - From powerhouse to processing plant: conserved roles of mitochondrial outer membrane proteins in tRNA splicing.
Wan Y et al. Genes Dev 2018 Oct 01;32(19-20):1309-1314
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.
Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:26670050 - Regulation of mRNA Levels by Decay-Promoting Introns that Recruit the Exosome Specificity Factor Mmi1.
Kilchert C et al. Cell Rep 2015 Dec 22;13(11):2504-2515
PMID:36478272 - Translation-complex profiling of fission yeast cells reveals dynamic rearrangements of scanning ribosomal subunits upon nutritional stress.
Duncan CDS et al. Nucleic Acids Res 2022 Dec 09;50(22):13011-13025
PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.
Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83