protein coding gene - uve1 (SPBC19C7.09c) - endonuclease Uve1

Gene summary

Standard name

uve1

Systematic ID

SPBC19C7.09c

Product

endonuclease Uve1

Organism

Schizosaccharomyces pombe (fission yeast)

Synonyms

uvde

UniProt ID

Q10988

ORFeome ID

33/33D09

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome II: 2837572..2839585 reverse strand

Annotation

Protein features

Orthologs

• uve1 (SJAG_01262) Schizosaccharomyces japonicus

References / Literature

PMID:9870697 - Differential effects of caffeine on DNA damage and replication cell cycle checkpoints in the fission yeast Schizosaccharomyces pombe.

Osman F et al. Mol Gen Genet 1998 Nov;260(4):319-34

PMID:10766807 - Alternative excision repair pathway of UV-damaged DNA in Schizosaccharomyces pombe operates both in nucleus and in mitochondria.

Yasuhira S et al. J Biol Chem 2000 Apr 21;275(16):11824-8

PMID:11523791 - A homologue of the Rad18 postreplication repair gene is required for DNA damage responses throughout the fission yeast cell cycle.

Verkade HM et al. Mol Genet Genomics 2001 Aug;265(6):993-1003

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:15367656 - Swi1 and Swi3 are components of a replication fork protection complex in fission yeast.

Noguchi E et al. Mol Cell Biol 2004 Oct;24(19):8342-55

PMID:25512493 - Regulation of the Rhp26ERCC6/CSB chromatin remodeler by a novel conserved leucine latch motif.

Wang L et al. Proc Natl Acad Sci U S A 2014 Dec 30;111(52):18566-71

PMID:8614629 - Characterization of a UV endonuclease gene from the fission yeast Schizosaccharomyces pombe and its bacterial homolog.

Takao M et al. Nucleic Acids Res 1996 Apr 01;24(7):1267-71

PMID:9566891 - Fission yeast rad12+ regulates cell cycle checkpoint control and is homologous to the Bloom's syndrome disease gene.

Davey S et al. Mol Cell Biol 1998 May;18(5):2721-8

PMID:14704348 - The major role of human AP-endonuclease homolog Apn2 in repair of abasic sites in Schizosaccharomyces pombe.

Ribar B et al. Nucleic Acids Res 2004;32(1):115-26

PMID:16857169 - The role of Schizosaccharomyces pombe DNA repair enzymes Apn1p and Uve1p in the base excision repair of apurinic/apyrimidinic sites.

Tanihigashi H et al. Biochem Biophys Res Commun 2006 Sep 08;347(4):889-94

PMID:9372918 - Role of Schizosaccharomyces pombe RecQ homolog, recombination, and checkpoint genes in UV damage tolerance.

Murray JM et al. Mol Cell Biol 1997 Dec;17(12):6868-75

PMID:31626996 - Multiplexed proteome profiling of carbon source perturbations in two yeast species with SL-SP3-TMT.

Paulo JA et al. J Proteomics 2020 Jan 06;210:103531

PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.

Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87

PMID:9708997 - Expression, purification, and characterization of ultraviolet DNA endonuclease from Schizosaccharomyces pombe.

Kaur B et al. Biochemistry 1998 Aug 18;37(33):11599-604

PMID:10652237 - Identification and characterization of the rhp23(+) DNA repair gene in Schizosaccharomyces pombe.

Lombaerts M et al. Biochem Biophys Res Commun 2000 Feb 05;268(1):210-5

PMID:14599746 - Fission yeast Uve1 and Apn2 function in distinct oxidative damage repair pathways in vivo.

Fraser JL et al. DNA Repair (Amst) 2003 Nov 21;2(11):1253-67

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.

Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7

PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.

Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704

PMID:17151242 - Sap1 promotes the association of the replication fork protection complex with chromatin and is involved in the replication checkpoint in Schizosaccharomyces pombe.

Noguchi C et al. Genetics 2007 Feb;175(2):553-66

PMID:29432178 - General amino acid control in fission yeast is regulated by a nonconserved transcription factor, with functions analogous to Gcn4/Atf4.

Duncan CDS et al. Proc Natl Acad Sci U S A 2018 Feb 20;115(8):E1829-E1838

PMID:10373519 - A Uve1p-mediated mismatch repair pathway in Schizosaccharomyces pombe.

Kaur B et al. Mol Cell Biol 1999 Jul;19(7):4703-10

PMID:10390527 - Removal of cyclobutane pyrimidine dimers by the UV damage repair and nucleotide excision repair pathways of Schizosaccharomyces pombe at nucleotide resolution.

Lombaerts M et al. Nucleic Acids Res 1999 Jul 15;27(14):2868-74

PMID:18794354 - Schizosaccharomyces pombe Ddb1 recruits substrate-specific adaptor proteins through a novel protein motif, the DDB-box.

Fukumoto Y et al. Mol Cell Biol 2008 Nov;28(22):6746-56

PMID:11719193 - Mus81-Eme1 are essential components of a Holliday junction resolvase.

Boddy MN et al. Cell 2001 Nov 16;107(4):537-48

PMID:15329725 - Separase-mediated cleavage of cohesin at interphase is required for DNA repair.

Nagao K et al. Nature 2004 Aug 26;430(7003):1044-8

PMID:10704216 - In vitro reconstitution of the Schizosaccharomyces pombe alternative excision repair pathway.

Alleva JL et al. Biochemistry 2000 Mar 14;39(10):2659-66

PMID:18769921 - Genetic analysis reveals different roles of Schizosaccharomyces pombe sfr1/dds20 in meiotic and mitotic DNA recombination and repair.

Khasanov FK et al. Curr Genet 2008 Oct;54(4):197-211

PMID:10801329 - Ultraviolet damage endonuclease (Uve1p): a structure and strand-specific DNA endonuclease.

Kaur B et al. Biochemistry 2000 May 16;39(19):5788-96

PMID:12807767 - Repair of damaged and mismatched DNA by the XPC homologues Rhp41 and Rhp42 of fission yeast.

Marti TM et al. Genetics 2003 Jun;164(2):457-67

PMID:28410370 - A systematic screen for morphological abnormalities during fission yeast sexual reproduction identifies a mechanism of actin aster formation for cell fusion.

Dudin O et al. PLoS Genet 2017 Apr;13(4):e1006721

GO_REF:0000111 - Gene Ontology annotations Inferred by Curator (IC) using at least one Inferred by Sequence Similarity (ISS) annotation to support the inference

PMID:33260998 - High-Throughput Flow Cytometry Combined with Genetic Analysis Brings New Insights into the Understanding of Chromatin Regulation of Cellular Quiescence.

Zahedi Y et al. Int J Mol Sci 2020 Nov 27;21(23)

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:26652183 - Coordination of DNA damage tolerance mechanisms with cell cycle progression in fission yeast.

Callegari AJ et al. Cell Cycle 2016;15(2):261-73

PMID:12161753 - The transcriptional program of meiosis and sporulation in fission yeast.

Mata J et al. Nat Genet 2002 Sep;32(1):143-7

PMID:21493688 - Cdt1 proteolysis is promoted by dual PIP degrons and is modulated by PCNA ubiquitylation.

Guarino E et al. Nucleic Acids Res 2011 Aug;39(14):5978-90

PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.

Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399

PMID:12000964 - Cnd2 has dual roles in mitotic condensation and interphase.

Aono N et al. Nature 2002 May 09;417(6885):197-202

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.

Rodríguez-López M et al. Elife 2023 Oct 03;12

PMID:8065916 - A new ATP-independent DNA endonuclease from Schizosaccharomyces pombe that recognizes cyclobutane pyrimidine dimers and 6-4 photoproducts.

Bowman KK et al. Nucleic Acids Res 1994 Aug 11;22(15):3026-32

PMID:12724426 - Role for the fission yeast RecQ helicase in DNA repair in G2.

Laursen LV et al. Mol Cell Biol 2003 May;23(10):3692-705

GO_REF:0000002 - Comments

PMID:9023111 - The fission yeast UVDR DNA repair pathway is inducible.

Davey S et al. Nucleic Acids Res 1997 Mar 01;25(5):1002-8

PMID:10446227 - Characterization of the rhp7(+) and rhp16(+) genes in Schizosaccharomyces pombe.

Lombaerts M et al. Nucleic Acids Res 1999 Sep 01;27(17):3410-6

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:16478984 - The Nse5-Nse6 dimer mediates DNA repair roles of the Smc5-Smc6 complex.

Pebernard S et al. Mol Cell Biol 2006 Mar;26(5):1617-30

PMID:9092661 - Characterization of the alternative excision repair pathway of UV-damaged DNA in Schizosaccharomyces pombe.

Yonemasu R et al. Nucleic Acids Res 1997 Apr 15;25(8):1553-8

PMID:22665798 - Induction of a G1-S checkpoint in fission yeast.

Bøe CA et al. Proc Natl Acad Sci U S A 2012 Jun 19;109(25):9911-6

PMID:12531030 - Two budding yeast RAD4 homologs in fission yeast play different roles in the repair of UV-induced DNA damage.

Fukumoto Y et al. DNA Repair (Amst) 2002 Oct 01;1(10):833-45

PMID:17307401 - The novel gene mus7(+) is involved in the repair of replication-associated DNA damage in fission yeast.

Yokoyama M et al. DNA Repair (Amst) 2007 Jun 01;6(6):770-80

PMID:11800554 - Role of the DNA repair nucleases Rad13, Rad2 and Uve1 of Schizosaccharomyces pombe in mismatch correction.

Kunz C et al. J Mol Biol 2001 Oct 19;313(2):241-53

PMID:10480889 - Transcription dependence and the roles of two excision repair pathways for UV damage in fission yeast Schizosaccharomyces pombe.

Yasuhira S et al. J Biol Chem 1999 Sep 17;274(38):26822-7

PMID:11073977 - Damage tolerance protein Mus81 associates with the FHA1 domain of checkpoint kinase Cds1.

Boddy MN et al. Mol Cell Biol 2000 Dec;20(23):8758-66

PMID:20452294 - Ubiquitin-PCNA fusion as a mimic for mono-ubiquitinated PCNA in Schizosaccharomyces pombe.

Ramasubramanyan S et al. DNA Repair (Amst) 2010 Jul 01;9(7):777-84