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protein coding gene - puc1 (SPBC19F5.01c) - G1 cyclin Puc1

Gene summary

Standard name
puc1
Systematic ID
SPBC19F5.01c
Product
G1 cyclin Puc1
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
SPBP8B7.32c
UniProt ID
P25009
ORFeome ID
32/32D10
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome II: 3699198..3701689 reverse strand

Annotation

Complementation

PBO:0016567 - functionally complements S. cerevisiae CLN3

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GO biological process

GO:0044843 - cell cycle G1/S phase transition

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GO:0110045 - negative regulation of cell cycle switching, mitotic to meiotic cell cycle

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GO:1900087 - positive regulation of G1/S transition of mitotic cell cycle

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GO:2000045 - regulation of G1/S transition of mitotic cell cycle

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GO:0023052 - signaling

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GO cellular component

GO:0000307 - cyclin-dependent protein kinase holoenzyme complex

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GO:0005829 - cytosol

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GO:0005634 - nucleus

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GO molecular function

GO:0016538 - cyclin-dependent protein serine/threonine kinase regulator activity

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Modification

MOD:00046 - O-phospho-L-serine

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MOD:00696 - phosphorylated residue

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Multi-locus phenotype

FYPO:0003066 - abnormal sporulation resulting in formation of ascus with fewer than four spores

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Genotypes:

FYPO:0003263 - abnormal sporulation resulting in formation of ascus with more than four spores

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Genotypes:

FYPO:0004077 - abnormal sporulation resulting in formation of ascus with single large spore

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Genotypes:

FYPO:0000681 - abnormal sporulation resulting in formation of two-spore ascus

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Genotypes:

FYPO:0004798 - abolished azygotic meiosis II

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Genotypes:

FYPO:0004800 - abolished premeiotic DNA replication during azygotic meiotic cell cycle

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Genotypes:

FYPO:0004799 - abolished zygotic meiosis II

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Genotypes:

FYPO:0003179 - decreased intragenic meiotic recombination

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Genotypes:

FYPO:0000708 - decreased mating efficiency

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Genotypes:

FYPO:0004089 - decreased meiotic recombination during zygotic meiosis

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Genotypes:

FYPO:0000581 - decreased spore germination frequency

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Genotypes:

FYPO:0004801 - delayed onset of premeiotic DNA replication during azygotic meiosis

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Genotypes:

FYPO:0004582 - increased cell cycle arrest in mitotic G1 phase in response to nitrogen starvation

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Genotypes:

FYPO:0002151 - inviable spore

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Genotypes:

FYPO:0001147 - normal mating efficiency

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Genotypes:

FYPO:0000478 - normal meiosis

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Genotypes:

FYPO:0003563 - normal meiosis I

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Genotypes:

FYPO:0002060 - viable vegetative cell population

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Genotypes:

Protein features

PBO:0111794 - cyclin

Qualitative gene expression

PomGeneEx:0000011 - RNA level increased

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Quantitative gene expression

PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0009078 - decreased cell population growth on ethanol carbon source

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Genotypes:

FYPO:0000470 - decreased mating type switching

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Genotypes:

FYPO:0000712 - delayed onset of cell cycle arrest in mitotic G1 phase in response to nitrogen starvation

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Genotypes:

FYPO:0000477 - delayed onset of meiosis

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Genotypes:

FYPO:0009093 - increased cell population growth on lysine and serine nitrogen source

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Genotypes:

FYPO:0001043 - increased mating efficiency

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Genotypes:

FYPO:0000012 - mitotic G2/M phase transition delay

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Genotypes:

FYPO:0004099 - normal mitotic chromosome condensation

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Genotypes:

FYPO:0001112 - premature cell cycle arrest in mitotic G1 phase in response to nitrogen starvation

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Genotypes:

FYPO:0000479 - premature meiosis

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Genotypes:

FYPO:0009041 - resistance to 2,2′-dipyridyl

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Genotypes:

FYPO:0002693 - resistance to diamide

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Genotypes:

FYPO:0009038 - resistance to egtazic acid

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Genotypes:

FYPO:0002578 - resistance to hydroxyurea

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Genotypes:

FYPO:0009039 - resistance to potassium chloride

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Genotypes:

FYPO:0003383 - resistance to tert-butyl hydroperoxide

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Genotypes:

FYPO:0000084 - sensitive to 6-azauracil

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Genotypes:

FYPO:0006680 - sensitive to bisphenol A

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Genotypes:

FYPO:0001501 - sensitive to brefeldin A

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Genotypes:

FYPO:0000104 - sensitive to cycloheximide

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Genotypes:

FYPO:0001719 - sensitive to lithium

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Genotypes:

FYPO:0009086 - sensitive to lithium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0001492 - viable elongated vegetative cell

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Genotypes:

FYPO:0003481 - viable elongated vegetative cell, elongated upon mitotic entry

References:

Genotypes:

FYPO:0002060 - viable vegetative cell population

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Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

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Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0000110 - orthologs cannot be distinguished

Protein features

IDNameInterPro nameDB name
PF00134Cyclin_NCyclin_NPFAM
cd20559CYCLIN_ScCLN_likeCDD
SM00385cyclin_7Cyclin-like_domSMART
G3DSA:1.10.472.10:FF:000010FUNFAM
SSF47954Cyclin-likeCyclin-like_sfSUPERFAMILY
G3DSA:1.10.472.10GENE3D
PTHR10177CYCLINSCyclinPANTHER
PIRSF001770Cyclin_CLNCyclin_CLNPIRSF

Orthologs

References / Literature

PMID:26173815 - Genome-wide screen of fission yeast mutants for sensitivity to 6-azauracil, an inhibitor of transcriptional elongation.
Zhou H et al. Yeast 2015 Oct;32(10):643-55
PMID:9201720 - Ran1 functions to control the Cdc10/Sct1 complex through Puc1.
Caligiuri M et al. Mol Biol Cell 1997 Jun;8(6):1117-28
PMID:24047646 - Pom1 and cell size homeostasis in fission yeast.
Wood E et al. Cell Cycle 2013 Oct 01;12(19):3228-36
PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.
Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:10679013 - The puc1 cyclin regulates the G1 phase of the fission yeast cell cycle in response to cell size.
Martín-Castellanos C et al. Mol Biol Cell 2000 Feb;11(2):543-54
PMID:25375137 - Systematic analysis of the role of RNA-binding proteins in the regulation of RNA stability.
Hasan A et al. PLoS Genet 2014 Nov;10(11):e1004684
PMID:27984744 - Survival in Quiescence Requires the Euchromatic Deployment of Clr4/SUV39H by Argonaute-Associated Small RNAs.
Joh RI et al. Mol Cell 2016 Dec 15;64(6):1088-1101
PMID:29735745 - Control of mitotic chromosome condensation by the fission yeast transcription factor Zas1.
Schiklenk C et al. J Cell Biol 2018 Jul 02;217(7):2383-2401
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:30640914 - CDK contribution to DSB formation and recombination in fission yeast meiosis.
Bustamante-Jaramillo LF et al. PLoS Genet 2019 Jan;15(1):e1007876
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:29852001 - New insights into donor directionality of mating-type switching in Schizosaccharomyces pombe.
Maki T et al. PLoS Genet 2018 May;14(5):e1007424
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
GO_REF:0000051 - S. pombe keyword mapping
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.
Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399
PMID:1828291 - Identification of a G1-type cyclin puc1+ in the fission yeast Schizosaccharomyces pombe.
Forsburg SL et al. Nature 1991 May 16;351(6323):245-8
PMID:32435206 - Posttranslational Arginylation Enzyme Arginyltransferase1 Shows Genetic Interactions With Specific Cellular Pathways in vivo .
Wiley DJ et al. Front Physiol 2020;11:427
PMID:10982385 - A pcl-like cyclin activates the Res2p-Cdc10p cell cycle "start" transcriptional factor complex in fission yeast.
Tanaka K et al. Mol Biol Cell 2000 Sep;11(9):2845-62
PMID:25891897 - A single cyclin-CDK complex is sufficient for both mitotic and meiotic progression in fission yeast.
Gutiérrez-Escribano P et al. Nat Commun 2015 Apr 20;6:6871
PMID:29084823 - Phosphorylation of the RNA-binding protein Zfs1 modulates sexual differentiation in fission yeast.
Navarro FJ et al. J Cell Sci 2017 Dec 15;130(24):4144-4154
PMID:8006074 - Analysis of the Schizosaccharomyces pombe cyclin puc1: evidence for a role in cell cycle exit.
Forsburg SL et al. J Cell Sci 1994 Mar;107 ( Pt 3):601-13
PMID:18818364 - Conservation and rewiring of functional modules revealed by an epistasis map in fission yeast.
Roguev A et al. Science 2008 Oct 17;322(5900):405-10
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.
Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
PMID:7909513 - A B-type cyclin negatively regulates conjugation via interacting with cell cycle 'start' genes in fission yeast.
Obara-Ishihara T et al. EMBO J 1994 Apr 15;13(8):1863-72
PMID:30647105 - Comparative Genomic Screen in Two Yeasts Reveals Conserved Pathways in the Response Network to Phenol Stress.
Alhoch B et al. G3 (Bethesda) 2019 Mar 07;9(3):639-650
PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.
Skribbe M et al. Mol Cell 2025 Feb 19;