protein coding gene - msh2 (SPBC19G7.01c) - MutS protein homolog 2

Gene summary

Standard name

msh2

Systematic ID

SPBC19G7.01c

Product

MutS protein homolog 2

Organism

Schizosaccharomyces pombe (fission yeast)

Synonyms

swi8, mut3, SPBC24C6.12c

UniProt ID

O74773

ORFeome ID

38/38A03

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome II: 2343653..2347723 reverse strand

Annotation

Protein features

Orthologs

• MSH2 (HGNC:7325) Homo sapiens
• msh2 (SJAG_02226) Schizosaccharomyces japonicus
• MSH2 (YOL090W) Saccharomyces cerevisiae

References / Literature

GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.

Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7

PMID:9858548 - The msh2 gene of Schizosaccharomyces pombe is involved in mismatch repair, mating-type switching, and meiotic chromosome organization.

Rudolph C et al. Mol Cell Biol 1999 Jan;19(1):241-50

PMID:11333219 - Control of GT repeat stability in Schizosaccharomyces pombe by mismatch repair factors.

Mansour AA et al. Genetics 2001 May;158(1):77-85

PMID:12617726 - Mutagenesis of the HMGB (high-mobility group B) protein Cmb1 (cytosine-mismatch binding 1) of Schizosaccharomyces pombe: effects on recognition of DNA mismatches and damage.

Kunz C et al. Biochem J 2003 Jun 01;372(Pt 2):651-60

PMID:25795664 - Genetic Interaction Landscape Reveals Critical Requirements for Schizosaccharomyces pombe Brc1 in DNA Damage Response Mutants.

Sánchez A et al. G3 (Bethesda) 2015 Mar 19;5(5):953-62

PMID:11800554 - Role of the DNA repair nucleases Rad13, Rad2 and Uve1 of Schizosaccharomyces pombe in mismatch correction.

Kunz C et al. J Mol Biol 2001 Oct 19;313(2):241-53

PMID:22540037 - Predicting the fission yeast protein interaction network.

Pancaldi V et al. G3 (Bethesda) 2012 Apr;2(4):453-67

PMID:32355220 - DNA replication machinery prevents Rad52-dependent single-strand annealing that leads to gross chromosomal rearrangements at centromeres.

Onaka AT et al. Commun Biol 2020 Apr 30;3(1):202

PMID:18388861 - Mus81 is essential for sister chromatid recombination at broken replication forks.

Roseaulin L et al. EMBO J 2008 May 07;27(9):1378-87

PMID:18931302 - Significant conservation of synthetic lethal genetic interaction networks between distantly related eukaryotes.

Dixon SJ et al. Proc Natl Acad Sci U S A 2008 Oct 28;105(43):16653-8

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:12807767 - Repair of damaged and mismatched DNA by the XPC homologues Rhp41 and Rhp42 of fission yeast.

Marti TM et al. Genetics 2003 Jun;164(2):457-67

PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.

Rodríguez-López M et al. Elife 2023 Oct 03;12

PMID:24719968 - Switching genes in Schizosaccharomyces pombe.

Gutz H et al. Curr Genet 1985;9(5):325-31

PMID:29084823 - Phosphorylation of the RNA-binding protein Zfs1 modulates sexual differentiation in fission yeast.

Navarro FJ et al. J Cell Sci 2017 Dec 15;130(24):4144-4154

PMID:6587363 - Genes required for initiation and resolution steps of mating-type switching in fission yeast.

Egel R et al. Proc Natl Acad Sci U S A 1984 Jun;81(11):3481-5

PMID:29852001 - New insights into donor directionality of mating-type switching in Schizosaccharomyces pombe.

Maki T et al. PLoS Genet 2018 May;14(5):e1007424

PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs

PMID:29259000 - Genes Important for Schizosaccharomyces pombe Meiosis Identified Through a Functional Genomics Screen.

Blyth J et al. Genetics 2018 Feb;208(2):589-603

PMID:31712578 - DNA sequence differences are determinants of meiotic recombination outcome.

Brown SD et al. Sci Rep 2019 Nov 11;9(1):16446

PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.

Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704

PMID:7851760 - The mutator gene swi8 effects specific mutations in the mating-type region of Schizosaccharomyces pombe.

Fleck O et al. Genetics 1994 Nov;138(3):621-32

PMID:9871115 - Schizosaccharomyces pombe exo1 is involved in the same mismatch repair pathway as msh2 and pms1.

Rudolph C et al. Curr Genet 1998 Dec;34(5):343-50

PMID:33260998 - High-Throughput Flow Cytometry Combined with Genetic Analysis Brings New Insights into the Understanding of Chromatin Regulation of Cellular Quiescence.

Zahedi Y et al. Int J Mol Sci 2020 Nov 27;21(23)

PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36

PMID:28218250 - Chromatin remodeller Fun30 Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.

Lee J et al. Nat Commun 2017 Feb 20;8:14527

PMID:15805471 - Ddb1 controls genome stability and meiosis in fission yeast.

Holmberg C et al. Genes Dev 2005 Apr 01;19(7):853-62

PMID:19547744 - Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.

Beltrao P et al. PLoS Biol 2009 Jun 16;7(6):e1000134

PMID:26167880 - SR protein kinases promote splicing of nonconsensus introns.

Lipp JJ et al. Nat Struct Mol Biol 2015 Aug;22(8):611-7

GO_REF:0000002 - Comments

PMID:12713814 - Different frameshift mutation spectra in non-repetitive DNA of MutSalpha- and MutLalpha-deficient fission yeast cells.

Marti TM et al. DNA Repair (Amst) 2003 May 13;2(5):571-80

PMID:11333218 - Requirement for Msh6, but not for Swi4 (Msh3), in Msh2-dependent repair of base-base mismatches and mononucleotide loops in Schizosaccharomyces pombe.

Tornier C et al. Genetics 2001 May;158(1):65-75

PB_REF:0000003 - Disease Association Curation

PMID:27611590 - Pfh1 Is an Accessory Replicative Helicase that Interacts with the Replisome to Facilitate Fork Progression and Preserve Genome Integrity.

McDonald KR et al. PLoS Genet 2016 Sep;12(9):e1006238

PMID:22144917 - The major roles of DNA polymerases epsilon and delta at the eukaryotic replication fork are evolutionarily conserved.

Miyabe I et al. PLoS Genet 2011 Dec;7(12):e1002407

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:23779158 - The proteasome factor Bag101 binds to Rad22 and suppresses homologous recombination.

Saito Y et al. Sci Rep 2013;3:2022

GO_REF:0000033 - Annotation inferences using phylogenetic trees