protein coding gene - bgs1 (SPBC19G7.05c) - primary septum and spore wall linear 1,3-beta-glucan synthase catalytic subunit Bgs1

Gene summary

Standard name

bgs1

Systematic ID

SPBC19G7.05c

Product

primary septum and spore wall linear 1,3-beta-glucan synthase catalytic subunit Bgs1

Organism

Schizosaccharomyces pombe (fission yeast)

Synonyms

cps1, drc1, swl1

UniProt ID

Q10287

ORFeome ID

48/48H01

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome II: 2350922..2357364 reverse strand

Annotation

Protein features

Orthologs

• bgs1 (SJAG_02222) Schizosaccharomyces japonicus
• GSC2 (YGR032W) Saccharomyces cerevisiae
• FKS1 (YLR342W) Saccharomyces cerevisiae
• FKS3 (YMR306W) Saccharomyces cerevisiae

References / Literature

PMID:24790095 - Characterization of the roles of Blt1p in fission yeast cytokinesis.

Goss JW et al. Mol Biol Cell 2014 Jul 01;25(13):1946-57

PMID:41259369 - Hydroxyurea induces an oxidative stress response that triggers ER expansion and cytoplasmic protein aggregation.

Sánchez-Molina A et al. PLoS Biol 2025 Nov 19;23(11):e3003493

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:11069657 - bgs2+, a sporulation-specific glucan synthase homologue is required for proper ascospore wall maturation in fission yeast.

Martín V et al. Mol Microbiol 2000 Oct;38(2):308-21

PMID:30044717 - Roles of the fission yeast UNC-13/Munc13 protein Ync13 in late stages of cytokinesis.

Zhu YH et al. Mol Biol Cell 2018 Sep 15;29(19):2259-2279

PMID:29813053 - Specific detection of fission yeast primary septum reveals septum and cleavage furrow ingression during early anaphase independent of mitosis completion.

G Cortés JC et al. PLoS Genet 2018 May;14(5):e1007388

PMID:32182184 - Cdc42 promotes Bgs1 recruitment for septum synthesis and glucanase localization for cell separation during cytokinesis in fission yeast.

Onwubiko UN et al. Small GTPases 2021 Jul;12(4):257-264

PMID:27168121 - Discovery of genes involved in mitosis, cell division, cell wall integrity and chromosome segregation through construction of Schizosaccharomyces pombe deletion strains.

Chen JS et al. Yeast 2016 Sep;33(9):507-17

PMID:16085489 - The 14-3-3 protein rad24p modulates function of the cdc14p family phosphatase clp1p/flp1p in fission yeast.

Mishra M et al. Curr Biol 2005 Aug 09;15(15):1376-83

PMID:16096637 - Fission yeast MO25 protein is localized at SPB and septum and is essential for cell morphogenesis.

Kanai M et al. EMBO J 2005 Sep 07;24(17):3012-25

PMID:25977474 - A role for F-BAR protein Rga7p during cytokinesis in S. pombe.

Arasada R et al. J Cell Sci 2015 Jul 01;128(13):2259-68

PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.

Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7

PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.

Skribbe M et al. Mol Cell 2025 Feb 19;

PMID:11152613 - Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes.

Krogh A et al. J Mol Biol 2001 Jan 19;305(3):567-80

PMID:1524835 - Isolation and characterization of mutants supersensitive to the spindle poison, isopropyl N-3-chlorophenyl carbamate (CIPC) in the fission yeast Schizosaccharomyces pombe.

Ishiguro J et al. Jpn J Genet 1992 Apr;67(2):97-109

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:23271606 - Fission yeast TOR signaling is essential for the down-regulation of a hyperactivated stress-response MAP kinase under salt stress.

Ishiguro J et al. Mol Genet Genomics 2013 Feb;288(1-2):63-75

PMID:12637524 - Zinc finger protein Prz1 regulates Ca2+ but not Cl- homeostasis in fission yeast. Identification of distinct branches of calcineurin signaling pathway in fission yeast.

Hirayama S et al. J Biol Chem 2003 May 16;278(20):18078-84

PMID:27298342 - Identification of S-phase DNA damage-response targets in fission yeast reveals conservation of damage-response networks.

Willis NA et al. Proc Natl Acad Sci U S A 2016 Jun 28;113(26):E3676-85

PMID:39156640 - Fission yeast Bgs1 glucan synthase participates in the control of growth polarity and membrane traffic.

Ramos M et al. iScience 2024 Aug 16;27(8):110477

PMID:25428987 - The Cdc15 and Imp2 SH3 domains cooperatively scaffold a network of proteins that redundantly ensure efficient cell division in fission yeast.

Ren L et al. Mol Biol Cell 2015 Jan 15;26(2):256-69

PMID:39666777 - Fission yeast essential nuclear pore protein Nup211 regulates the expression of genes involved in cytokinesis.

Kamel D et al. PLoS One 2024;19(12):e0312095

PMID:40114852 - Characterization and comparison of Schizosaccharomyces pombe cdc15 temperature-sensitive mutants.

Turner LA et al. MicroPubl Biol 2025;2025

PMID:8887550 - Rho 1 GTPase activates the (1-3)beta-D-glucan synthase and is involved in Schizosaccharomyces pombe morphogenesis.

Arellano M et al. EMBO J 1996 Sep 02;15(17):4584-91

PMID:15507118 - An interactive gene network for securin-separase, condensin, cohesin, Dis1/Mtc1 and histones constructed by mass transformation.

Yuasa T et al. Genes Cells 2004 Nov;9(11):1069-82

PMID:16421249 - Rgf1p is a specific Rho1-GEF that coordinates cell polarization with cell wall biogenesis in fission yeast.

García P et al. Mol Biol Cell 2006 Apr;17(4):1620-31

PMID:19029336 - Schizosaccharomyces pombe Pak-related protein, Pak1p/Orb2p, phosphorylates myosin regulatory light chain to inhibit cytokinesis.

Loo TH et al. J Cell Biol 2008 Dec 01;183(5):785-93

PMID:21340088 - Microarray-based target identification using drug hypersensitive fission yeast expressing ORFeome.

Arita Y et al. Mol Biosyst 2011 May;7(5):1463-72

PMID:26132084 - Cooperation between Paxillin-like Protein Pxl1 and Glucan Synthase Bgs1 Is Essential for Actomyosin Ring Stability and Septum Formation in Fission Yeast.

Cortés JC et al. PLoS Genet 2015 Jul;11(7):e1005358

PMID:27749909 - A New Membrane Protein Sbg1 Links the Contractile Ring Apparatus and Septum Synthesis Machinery in Fission Yeast.

Sethi K et al. PLoS Genet 2016 Oct;12(10):e1006383

PMID:29996109 - Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe.

Swaffer MP et al. Cell Rep 2018 Jul 10;24(2):503-514

PMID:21712547 - Mitotic substrates of the kinase aurora with roles in chromatin regulation identified through quantitative phosphoproteomics of fission yeast.

Koch A et al. Sci Signal 2011 Jun 28;4(179):rs6

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:30928696 - Distinct Roles of Myosin-II Isoforms in Cytokinesis under Normal and Stressed Conditions.

Okada H et al. iScience 2019 Apr 26;14:69-87

PMID:26412298 - A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.

Beckley JR et al. Mol Cell Proteomics 2015 Dec;14(12):3132-41

PMID:15647375 - The roles of fission yeast ase1 in mitotic cell division, meiotic nuclear oscillation, and cytokinesis checkpoint signaling.

Yamashita A et al. Mol Biol Cell 2005 Mar;16(3):1378-95

PMID:24165938 - Extracellular cell wall β(1,3)glucan is required to couple septation to actomyosin ring contraction.

Muñoz J et al. J Cell Biol 2013 Oct 28;203(2):265-82

PMID:18303049 - Chemical genetic analysis of the regulatory role of Cdc2p in the S. pombe septation initiation network.

Dischinger S et al. J Cell Sci 2008 Mar 15;121(Pt 6):843-53

PMID:19075108 - Assembly of normal actomyosin rings in the absence of Mid1p and cortical nodes in fission yeast.

Huang Y et al. J Cell Biol 2008 Dec 15;183(6):979-88

PMID:25825517 - A formin-nucleated actin aster concentrates cell wall hydrolases for cell fusion in fission yeast.

Dudin O et al. J Cell Biol 2015 Mar 30;208(7):897-911

PMID:15615781 - The novel fission yeast (1,3)beta-D-glucan synthase catalytic subunit Bgs4p is essential during both cytokinesis and polarized growth.

Cortés JC et al. J Cell Sci 2005 Jan 01;118(Pt 1):157-74

PMID:26749213 - The AP-2 complex is required for proper temporal and spatial dynamics of endocytic patches in fission yeast.

de León N et al. Mol Microbiol 2016 May;100(3):409-24

PMID:26941334 - Unique spatiotemporal activation pattern of Cdc42 by Gef1 and Scd1 promotes different events during cytokinesis.

Wei B et al. Mol Biol Cell 2016 Apr 15;27(8):1235-45

PMID:34402513 - Phosphorylation in the intrinsically disordered region of F-BAR protein Imp2 regulates its contractile ring recruitment.

Willet AH et al. J Cell Sci 2021 Aug 15;134(16)

PMID:18256290 - Schizosaccharomyces pombe Pxl1 is a paxillin homologue that modulates Rho1 activity and participates in cytokinesis.

Pinar M et al. Mol Biol Cell 2008 Apr;19(4):1727-38

PMID:9401022 - cps1+, a Schizosaccharomyces pombe gene homolog of Saccharomyces cerevisiae FKS genes whose mutation confers hypersensitivity to cyclosporin A and papulacandin B.

Ishiguro J et al. J Bacteriol 1997 Dec;179(24):7653-62

PMID:23977061 - Regulation of cell wall synthesis by the clathrin light chain is essential for viability in Schizosaccharomyces pombe.

de León N et al. PLoS One 2013;8(8):e71510

PMID:35108037 - Fission yeast paxillin contains two Cdc15 binding motifs for robust recruitment to the cytokinetic ring.

Snider CE et al. Mol Biol Cell 2022 Apr 01;33(4):br4

PMID:34959732 - Echinocandin Drugs Induce Differential Effects in Cytokinesis Progression and Cell Integrity.

Yagüe N et al. Pharmaceuticals (Basel) 2021 Dec 20;14(12)

PMID:23060961 - Cdc42 regulation of polarized traffic in fission yeast.

Estravis M et al. Commun Integr Biol 2012 Jul 01;5(4):370-3

PMID:19237545 - The fission yeast SEL1 domain protein Cfh3p: a novel regulator of the glucan synthase Bgs1p whose function is more relevant under stress conditions.

Sharifmoghadam MR et al. J Biol Chem 2009 Apr 24;284(17):11070-9

PMID:12356913 - Localization of the (1,3)beta-D-glucan synthase catalytic subunit homologue Bgs1p/Cps1p from fission yeast suggests that it is involved in septation, polarized growth, mating, spore wall formation and spore germination.

Cortés JC et al. J Cell Sci 2002 Nov 01;115(Pt 21):4081-96

PMID:27082518 - Roles of the TRAPP-II Complex and the Exocyst in Membrane Deposition during Fission Yeast Cytokinesis.

Wang N et al. PLoS Biol 2016 Apr;14(4):e1002437

PMID:27385337 - Roles of the novel coiled-coil protein Rng10 in septum formation during fission yeast cytokinesis.

Liu Y et al. Mol Biol Cell 2016 Aug 15;27(16):2528-41

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:31553675 - The phosphatase inhibitor Sds23 regulates cell division symmetry in fission yeast.

Schutt KL et al. Mol Biol Cell 2019 Nov 01;30(23):2880-2889

PMID:23200991 - Cdc42 explores the cell periphery for mate selection in fission yeast.

Bendezú FO et al. Curr Biol 2013 Jan 07;23(1):42-7

PMID:15470240 - Schizosaccharomyces pombe Pmr1p is essential for cell wall integrity and is required for polarized cell growth and cytokinesis.

Cortés JC et al. Eukaryot Cell 2004 Oct;3(5):1124-35

PMID:11448769 - Fission yeast Clp1p phosphatase regulates G2/M transition and coordination of cytokinesis with cell cycle progression.

Trautmann S et al. Curr Biol 2001 Jun 26;11(12):931-40

PMID:23093943 - Cytokinesis-based constraints on polarized cell growth in fission yeast.

Bohnert KA et al. PLoS Genet 2012;8(10):e1003004

PMID:15800064 - Mto2p, a novel fission yeast protein required for cytoplasmic microtubule organization and anchoring of the cytokinetic actin ring.

Venkatram S et al. Mol Biol Cell 2005 Jun;16(6):3052-63

PMID:26702831 - Oligomerization but Not Membrane Bending Underlies the Function of Certain F-BAR Proteins in Cell Motility and Cytokinesis.

McDonald NA et al. Dev Cell 2015 Dec 21;35(6):725-36

PMID:16687577 - Cell cycle-dependent roles for the FCH-domain protein Cdc15p in formation of the actomyosin ring in Schizosaccharomyces pombe.

Wachtler V et al. Mol Biol Cell 2006 Jul;17(7):3254-66

PMID:34296454 - The TOR-dependent phosphoproteome and regulation of cellular protein synthesis.

Mak T et al. EMBO J 2021 Aug 16;40(16):e107911

PMID:38511077 - Generation and characterization of temperature-sensitive alleles of the glucanosyltransferase Gas1 in Schizosaccharomyces pombe.

Howard IV et al. MicroPubl Biol 2024;2024

PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.

Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105

PMID:15265986 - The Clp1p/Flp1p phosphatase ensures completion of cytokinesis in response to minor perturbation of the cell division machinery in Schizosaccharomyces pombe.

Mishra M et al. J Cell Sci 2004 Aug 01;117(Pt 17):3897-910

PMID:27898700 - Sbg1 Is a Novel Regulator for the Localization of the β-Glucan Synthase Bgs1 in Fission Yeast.

Davidson R et al. PLoS One 2016;11(11):e0167043

PMID:24146635 - Hsp70-Hsp40 chaperone complex functions in controlling polarized growth by repressing Hsf1-driven heat stress-associated transcription.

Vjestica A et al. PLoS Genet 2013;9(10):e1003886

PMID:30332655 - Paxillin-Mediated Recruitment of Calcineurin to the Contractile Ring Is Required for the Correct Progression of Cytokinesis in Fission Yeast.

Martín-García R et al. Cell Rep 2018 Oct 16;25(3):772-783.e4

PMID:31509478 - The intrinsically disordered region of the cytokinetic F-BAR protein Cdc15 performs a unique essential function in maintenance of cytokinetic ring integrity.

Mangione MC et al. Mol Biol Cell 2019 Oct 15;30(22):2790-2801

PMID:10503548 - Analysis of the cps1 gene provides evidence for a septation checkpoint in Schizosaccharomyces pombe.

Le Goff X et al. Mol Gen Genet 1999 Aug;262(1):163-72

PMID:21652630 - Characterization of Mug33 reveals complementary roles for actin cable-dependent transport and exocyst regulators in fission yeast exocytosis.

Snaith HA et al. J Cell Sci 2011 Jul 01;124(Pt 13):2187-99

PMID:22905165 - The integrity of the cytokinesis machinery under stress conditions requires the glucan synthase Bgs1p and its regulator Cfh3p.

Sharifmoghadam MR et al. PLoS One 2012;7(8):e42726

PMID:37792890 - Elevated levels of sphingolipid MIPC in the plasma membrane disrupt the coordination of cell growth with cell wall formation in fission yeast.

Willet AH et al. PLoS Genet 2023 Oct;19(10):e1010987

PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.

Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963

PMID:15146064 - Disruption of astral microtubule contact with the cell cortex activates a Bub1, Bub3, and Mad3-dependent checkpoint in fission yeast.

Tournier S et al. Mol Biol Cell 2004 Jul;15(7):3345-56

PMID:10704373 - A checkpoint that monitors cytokinesis in Schizosaccharomyces pombe.

Liu J et al. J Cell Sci 2000 Apr;113 ( Pt 7):1223-30

PMID:10545452 - Drc1p/Cps1p, a 1,3-beta-glucan synthase subunit, is essential for division septum assembly in Schizosaccharomyces pombe.

Liu J et al. Genetics 1999 Nov;153(3):1193-203

PMID:12796296 - Scw1p antagonizes the septation initiation network to regulate septum formation and cell separation in the fission yeast Schizosaccharomyces pombe.

Jin QW et al. Eukaryot Cell 2003 Jun;2(3):510-20

PMID:20624220 - Kin1 is a plasma membrane-associated kinase that regulates the cell surface in fission yeast.

Cadou A et al. Mol Microbiol 2010 Sep;77(5):1186-202

PMID:23615450 - Separate roles of IQGAP Rng2p in forming and constricting the Schizosaccharomyces pombe cytokinetic contractile ring.

Tebbs IR et al. Mol Biol Cell 2013 Jun;24(12):1904-17

PMID:16772338 - The fission yeast Chs2 protein interacts with the type-II myosin Myo3p and is required for the integrity of the actomyosin ring.

Martín-García R et al. J Cell Sci 2006 Jul 01;119(Pt 13):2768-79

PMID:18562696 - The meiosis-specific Sid2p-related protein Slk1p regulates forespore membrane assembly in fission yeast.

Yan H et al. Mol Biol Cell 2008 Sep;19(9):3676-90

PMID:23087209 - The kinesin-14 Klp2 is negatively regulated by the SIN for proper spindle elongation and telophase nuclear positioning.

Mana-Capelli S et al. Mol Biol Cell 2012 Dec;23(23):4592-600

PMID:21148300 - Actin cables and the exocyst form two independent morphogenesis pathways in the fission yeast.

Bendezú FO et al. Mol Biol Cell 2011 Jan 01;22(1):44-53

PMID:19547744 - Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.

Beltrao P et al. PLoS Biol 2009 Jun 16;7(6):e1000134

PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36

PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.

Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87

PMID:18378776 - The Clp1/Cdc14 phosphatase contributes to the robustness of cytokinesis by association with anillin-related Mid1.

Clifford DM et al. J Cell Biol 2008 Apr 07;181(1):79-88

PMID:36749320 - Multiple polarity kinases inhibit phase separation of F-BAR protein Cdc15 and antagonize cytokinetic ring assembly in fission yeast.

Bhattacharjee R et al. Elife 2023 Feb 07;12

PMID:24115772 - SIN-dependent phosphoinhibition of formin multimerization controls fission yeast cytokinesis.

Bohnert KA et al. Genes Dev 2013 Oct 01;27(19):2164-77

PMID:41144523 - The Ync13-Rga7-Rng10 complex selectively coordinates secretory vesicle trafficking and secondary septum formation during cytokinesis.

Zhang S et al. PLoS Biol 2025 Oct 27;23(10):e3003466

PMID:22891259 - Fission yeast Ags1 confers the essential septum strength needed for safe gradual cell abscission.

Cortés JC et al. J Cell Biol 2012 Aug 20;198(4):637-56

PMID:15923187 - Phosphatidylinositol-4-phosphate 5-kinase regulates fission yeast cell integrity through a phospholipase C-mediated protein kinase C-independent pathway.

Deng L et al. J Biol Chem 2005 Jul 29;280(30):27561-8

PMID:31116668 - Fission yeast TRP channel Pkd2p localizes to the cleavage furrow and regulates cell separation during cytokinesis.

Morris Z et al. Mol Biol Cell 2019 Jul 15;30(15):1791-1804

PMID:27974503 - Traffic Through the Trans-Golgi Network and the Endosomal System Requires Collaboration Between Exomer and Clathrin Adaptors in Fission Yeast.

Hoya M et al. Genetics 2017 Feb;205(2):673-690

PMID:20603077 - Dephosphorylation of F-BAR protein Cdc15 modulates its conformation and stimulates its scaffolding activity at the cell division site.

Roberts-Galbraith RH et al. Mol Cell 2010 Jul 09;39(1):86-99

PMID:23934882 - Negative functional interaction between cell integrity MAPK pathway and Rho1 GTPase in fission yeast.

Viana RA et al. Genetics 2013 Oct;195(2):421-32

PMID:40668835 - α-glucan remodeling by GH13-domain enzymes shapes fungal cell wall architecture.

Jacob A et al. Proc Natl Acad Sci U S A 2025 Jul 22;122(29):e2505509122

PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.

Strachan J et al. J Cell Sci 2023 Dec 01;136(23)

PMID:10504305 - Schizosaccharomyces pombe protein kinase C homologues, pck1p and pck2p, are targets of rho1p and rho2p and differentially regulate cell integrity.

Arellano M et al. J Cell Sci 1999 Oct;112 ( Pt 20):3569-78

PMID:18257517 - Phosphoproteome analysis of fission yeast.

Wilson-Grady JT et al. J Proteome Res 2008 Mar;7(3):1088-97

PMID:34910579 - Involvement of Smi1 in cell wall integrity and glucan synthase Bgs4 localization during fission yeast cytokinesis.

Longo LVG et al. Mol Biol Cell 2022 Feb 01;33(2):ar17

PMID:11297516 - Its8, a fission yeast homolog of Mcd4 and Pig-n, is involved in GPI anchor synthesis and shares an essential function with calcineurin in cytokinesis.

Yada T et al. J Biol Chem 2001 Apr 27;276(17):13579-86

PMID:16421926 - A critical role for the type V myosin, Myo52, in septum deposition and cell fission during cytokinesis in Schizosaccharomyces pombe.

Mulvihill DP et al. Cell Motil Cytoskeleton 2006 Mar;63(3):149-61

PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.

Halova L et al. Open Biol 2021 Apr;11(4):200405

PMID:12791993 - Equatorial retention of the contractile actin ring by microtubules during cytokinesis.

Pardo M et al. Science 2003 Jun 06;300(5625):1569-74

PMID:21504829 - Yeast SREBP cleavage activation requires the Golgi Dsc E3 ligase complex.

Stewart EV et al. Mol Cell 2011 Apr 22;42(2):160-71