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protein coding gene - tbf1 (SPBC19G7.13) - DNA binding factor Trf1

Gene summary

Standard name
tbf1
Systematic ID
SPBC19G7.13
Product
DNA binding factor Trf1
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
trf1
UniProt ID
Q6E434
ORFeome ID
23/23E08
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome II: 2373925..2376516 forward strand

Annotation

Complementation

PBO:0004027 - functionally complemented by P. carnii Trb1

References:

GO biological process

GO:0000723 - telomere maintenance

References:

GO:0010833 - telomere maintenance via telomere lengthening

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GO cellular component

GO:0000785 - chromatin

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GO:0140445 - chromosome, telomeric repeat region

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GO:0005634 - nucleus

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GO molecular function

GO:0003691 - double-stranded telomeric DNA binding

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Modification

MOD:00046 - O-phospho-L-serine

References:

MOD:01149 - sumoylated lysine

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Protein features

PBO:0111844 - Myb family

PBO:0111879 - telobox motif

Quantitative gene expression

PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0002017 - abnormal cell cycle arrest in mitotic interphase before NETO

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Genotypes:

FYPO:0002007 - abnormal chromosome morphology, single irregular mass

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Genotypes:

FYPO:0000059 - abnormal mitotic cell cycle

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Genotypes:

FYPO:0000122 - abnormal telomere maintenance during vegetative growth

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Genotypes:

FYPO:0001683 - abolished mitotic spindle assembly

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Genotypes:

FYPO:0001018 - abolished NETO

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Genotypes:

FYPO:0005018 - decreased double-stranded DNA binding

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Genotypes:

FYPO:0002019 - elongated telomeres during vegetative growth

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Genotypes:

FYPO:0008358 - increased protein aggregate level

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Genotypes:

FYPO:0002276 - increased protein degradation

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Genotypes:

FYPO:0000314 - inviable after spore germination with elongated germ tube

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Genotypes:

FYPO:0002151 - inviable spore

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Genotypes:

FYPO:0001994 - inviable swollen elongated mononucleate vegetative cell with mislocalized septum near new end

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Genotypes:

FYPO:0002061 - inviable vegetative cell population

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Genotypes:

FYPO:0001397 - monopolar actin cortical patch localization to old end

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Genotypes:

FYPO:0002155 - normal telomere structure during vegetative growth

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Genotypes:

FYPO:0003902 - resistance to etoposide

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Genotypes:

Subunit composition

PBO:0015212 - homomeric(2)

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF00249Myb_DNA-bindingSANT/MybPfam
PF08558TRFTelomere_rpt-bd_fac_dimer_domPfam
cd11660SANT_TRFCDD
PS50090MYB_LIKESANT/MybPROSITE profiles
PS51294HTH_MYBMyb_domPROSITE profiles
SM00717SANTSANT/MybSMART
G3DSA:1.10.10.60:FF:000137CATH-FunFam
G3DSA:1.10.10.60CATH-Gene3D
SSF46689Homeodomain-like_sfSUPERFAMILY
PTHR47807Telomeric_DNA-bd_trans-regPANTHER
mobidb-lite-Disorderdisorder_predictionMobiDB-Disorder
mobidb-lite-Polyampholytedisorder_predictionMobiDB-Polyampholyte

Orthologs

References / Literature

PMID:17977837 - Identification and characterization of an essential telomeric repeat binding factor in fission yeast.
Pitt CW et al. J Biol Chem 2008 Feb 01;283(5):2693-701
PMID:20118936 - Schizosaccharomyces pombe genome-wide nucleosome mapping reveals positioning mechanisms distinct from those of Saccharomyces cerevisiae.
Lantermann AB et al. Nat Struct Mol Biol 2010 Feb;17(2):251-7
PMID:31474649 - Identification of 15 New Bypassable Essential Genes of Fission Yeast.
Takeda A et al. Cell Struct Funct 2019 Sep 27;44(2):113-119
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:26537787 - Targeting of SUMO substrates to a Cdc48-Ufd1-Npl4 segregase and STUbL pathway in fission yeast.
Køhler JB et al. Nat Commun 2015 Nov 05;6:8827
PMID:27068713 - Timeless protection of telomeres.
Gadaleta MC et al. Curr Genet 2016 Nov;62(4):725-730
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.
Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:38677290 - Structural and functional insights into yeast Tbf1 as an atypical telomeric repeat-binding factor.
Wu Z et al. Structure 2024 Apr 17;
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:21340088 - Microarray-based target identification using drug hypersensitive fission yeast expressing ORFeome.
Arita Y et al. Mol Biosyst 2011 May;7(5):1463-72
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:19074598 - Functional differentiation of tbf1 orthologues in fission and budding yeasts.
Cockell MM et al. Eukaryot Cell 2009 Feb;8(2):207-16
PMID:28218250 - Chromatin remodeller Fun30 Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.
Lee J et al. Nat Commun 2017 Feb 20;8:14527
PMID:23163955 - Analysis of stress-induced duplex destabilization (SIDD) properties of replication origins, genes and intergenes in the fission yeast, Schizosaccharomyces pombe.
Yadav MP et al. BMC Res Notes 2012 Nov 19;5:643
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.
Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7