protein coding gene - leu1 (SPBC1A4.02c) - 3-isopropylmalate dehydrogenase Leu1

Gene summary

Standard name

leu1

Systematic ID

SPBC1A4.02c

Product

3-isopropylmalate dehydrogenase Leu1

Organism

Schizosaccharomyces pombe (fission yeast)

Synonyms

SPBC1E8.07c

UniProt ID

P18869

ORFeome ID

40/40C11

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome II: 1974390..1975674 reverse strand

Annotation

Protein features

Orthologs

• leu1 (SJAG_03562) Schizosaccharomyces japonicus
• LEU2 (YCL018W) Saccharomyces cerevisiae

References / Literature

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Snaith HA et al. J Cell Sci 2011 Jul 01;124(Pt 13):2187-99

PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.

Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323

PMID:31064814 - Proximity-dependent biotinylation mediated by TurboID to identify protein-protein interaction networks in yeast.

Larochelle M et al. J Cell Sci 2019 May 31;132(11)

PMID:23145069 - Identification and functional analysis of the erh1(+) gene encoding enhancer of rudimentary homolog from the fission yeast Schizosaccharomyces pombe.

Krzyzanowski MK et al. PLoS One 2012;7(11):e49059

PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.

Strachan J et al. J Cell Sci 2023 Dec 01;136(23)

PMID:17295836 - Fission yeast autophagy induced by nitrogen starvation generates a nitrogen source that drives adaptation processes.

Kohda TA et al. Genes Cells 2007 Feb;12(2):155-70

PMID:30640914 - CDK contribution to DSB formation and recombination in fission yeast meiosis.

Bustamante-Jaramillo LF et al. PLoS Genet 2019 Jan;15(1):e1007876

PMID:14745200 - Truncated Sla1 induces haploid meiosis through the Pat1-Mei2 system in fission yeast.

Tanabe K et al. Biosci Biotechnol Biochem 2004 Jan;68(1):266-70

PMID:19778961 - Autophagy-deficient Schizosaccharomyces pombe mutants undergo partial sporulation during nitrogen starvation.

Mukaiyama H et al. Microbiology (Reading) 2009 Dec;155(Pt 12):3816-3826

PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.

Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7

PMID:3063400 - The primary structure of the leu1+ gene of Schizosaccharomyces pombe.

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PMID:19620394 - Distinctive responses to nitrogen starvation in the dominant active mutants of the fission yeast Rheb GTPase.

Murai T et al. Genetics 2009 Oct;183(2):517-27

PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.

Skribbe M et al. Mol Cell 2025 Feb 19;

PMID:16115814 - Pas1, a G1 cyclin, regulates amino acid uptake and rescues a delay in G1 arrest in Tsc1 and Tsc2 mutants in Schizosaccharomyces pombe.

van Slegtenhorst M et al. Hum Mol Genet 2005 Oct 01;14(19):2851-8

PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.

Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963

PMID:17482430 - Multiple fungal enzymes possess cysteine synthase activity in vitro.

Brzywczy J et al. Res Microbiol 2007 Jun;158(5):428-36

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:34805795 - The fission yeast FLCN/FNIP complex augments TORC1 repression or activation in response to amino acid (AA) availability.

Calvo IA et al. iScience 2021 Nov 19;24(11):103338

PMID:37615341 - Schizosaccharomyces pombe Rtf2 is important for replication fork barrier activity of RTS1 via splicing of Rtf1 .

Budden AM et al. Elife 2023 Aug 24;12

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:12136010 - Role of the Tsc1-Tsc2 complex in signaling and transport across the cell membrane in the fission yeast Schizosaccharomyces pombe.

Matsumoto S et al. Genetics 2002 Jul;161(3):1053-63

PMID:15546162 - pDUAL, a multipurpose, multicopy vector capable of chromosomal integration in fission yeast.

Matsuyama A et al. Yeast 2004 Nov;21(15):1289-305

PMID:26412298 - A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.

Beckley JR et al. Mol Cell Proteomics 2015 Dec;14(12):3132-41

PMID:11069779 - The SHR3 homologue from S. pombe demonstrates a conserved function of ER packaging chaperones.

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PMID:8625425 - pH sensitivity of Schizosaccharomyces pombe: effect on the cellular phenotype associated with lacZ gene expression.

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PMID:28218250 - Chromatin remodeller Fun30 Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.

Lee J et al. Nat Commun 2017 Feb 20;8:14527

PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.

Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87

PMID:20485751 - Deletion of btn1, an orthologue of CLN3, increases glycolysis and perturbs amino acid metabolism in the fission yeast model of Batten disease.

Pears MR et al. Mol Biosyst 2010 Jun;6(6):1093-102

PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.

Halova L et al. Open Biol 2021 Apr;11(4):200405

PMID:31626996 - Multiplexed proteome profiling of carbon source perturbations in two yeast species with SL-SP3-TMT.

Paulo JA et al. J Proteomics 2020 Jan 06;210:103531

GO_REF:0000002 - Comments

PMID:26696398 - Autophagy is required for efficient meiosis progression and proper meiotic chromosome segregation in fission yeast.

Matsuhara H et al. Genes Cells 2016 Jan;21(1):65-87

PMID:15466417 - Regulation of leucine uptake by tor1+ in Schizosaccharomyces pombe is sensitive to rapamycin.

Weisman R et al. Genetics 2005 Feb;169(2):539-50

PMID:21511999 - Comparative functional genomics of the fission yeasts.

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PMID:27918601 - Identifying genes required for respiratory growth of fission yeast.

Malecki M et al. Wellcome Open Res 2016;1:12

PMID:22992726 - The SAGA histone acetyltransferase complex regulates leucine uptake through the Agp3 permease in fission yeast.

Takahashi H et al. J Biol Chem 2012 Nov 02;287(45):38158-67

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.

Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7

PMID:27984744 - Survival in Quiescence Requires the Euchromatic Deployment of Clr4/SUV39H by Argonaute-Associated Small RNAs.

Joh RI et al. Mol Cell 2016 Dec 15;64(6):1088-1101

PMID:34250083 - Barcode sequencing and a high-throughput assay for chronological lifespan uncover ageing-associated genes in fission yeast.

Romila CA et al. Microb Cell 2021 Jul 05;8(7):146-160

PMID:36302945 - Ferrichrome, a fungal-type siderophore, confers high ammonium tolerance to fission yeast.

Chiu PC et al. Sci Rep 2022 Oct 27;12(1):17411

PMID:9339351 - Identification of the ure1+ gene encoding urease in fission yeast.

Tange Y et al. Curr Genet 1997 Sep;32(3):244-6

PMID:20144990 - Fission yeast TORC1 regulates phosphorylation of ribosomal S6 proteins in response to nutrients and its activity is inhibited by rapamycin.

Nakashima A et al. J Cell Sci 2010 Mar 01;123(Pt 5):777-86

PMID:36478272 - Translation-complex profiling of fission yeast cells reveals dynamic rearrangements of scanning ribosomal subunits upon nutritional stress.

Duncan CDS et al. Nucleic Acids Res 2022 Dec 09;50(22):13011-13025

PMID:23934889 - TORC1 signaling is governed by two negative regulators in fission yeast.

Ma N et al. Genetics 2013 Oct;195(2):457-68

PMID:27887640 - Functional and regulatory profiling of energy metabolism in fission yeast.

Malecki M et al. Genome Biol 2016 Nov 25;17(1):240

PMID:35673994 - Actin assembly requirements of the formin Fus1 to build the fusion focus.

Billault-Chaumartin I et al. J Cell Sci 2022 Jul 01;135(13)

PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.

Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105

PMID:34496258 - Transcription and chromatin-based surveillance mechanism controls suppression of cryptic antisense transcription.

Heo DH et al. Cell Rep 2021 Sep 07;36(10):109671

PMID:27613427 - Stress sensitivity of a fission yeast strain lacking histidine kinases is rescued by the ectopic expression of Chk1 from Candida albicans.

Maksimov V et al. Curr Genet 2017 May;63(2):343-357

PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.

Rodríguez-López M et al. Elife 2023 Oct 03;12

PMID:18257517 - Phosphoproteome analysis of fission yeast.

Wilson-Grady JT et al. J Proteome Res 2008 Mar;7(3):1088-97

PMID:17248775 - Genetic Mapping in SCHIZOSACCHAROMYCES POMBE by Mitotic and Meiotic Analysis and Induced Haploidization.

Kohli J et al. Genetics 1977 Nov;87(3):471-89

PMID:17179073 - Opposite effects of tor1 and tor2 on nitrogen starvation responses in fission yeast.

Weisman R et al. Genetics 2007 Mar;175(3):1153-62

PMID:26404184 - High Confidence Fission Yeast SUMO Conjugates Identified by Tandem Denaturing Affinity Purification.

Nie M et al. Sci Rep 2015 Sep 25;5:14389

PMID:14718525 - Tsc1+ and tsc2+ regulate arginine uptake and metabolism in Schizosaccharomyces pombe.

van Slegtenhorst M et al. J Biol Chem 2004 Mar 26;279(13):12706-13

PMID:26152728 - A Two-step Protein Quality Control Pathway for a Misfolded DJ-1 Variant in Fission Yeast.

Mathiassen SG et al. J Biol Chem 2015 Aug 21;290(34):21141-21153

PMID:26537787 - Targeting of SUMO substrates to a Cdc48-Ufd1-Npl4 segregase and STUbL pathway in fission yeast.

Køhler JB et al. Nat Commun 2015 Nov 05;6:8827

PMID:27191590 - Fission Yeast SCYL1/2 Homologue Ppk32: A Novel Regulator of TOR Signalling That Governs Survival during Brefeldin A Induced Stress to Protein Trafficking.

Kowalczyk KM et al. PLoS Genet 2016 May;12(5):e1006041

PMID:30355493 - Expanded Interactome of the Intrinsically Disordered Protein Dss1.

Schenstrøm SM et al. Cell Rep 2018 Oct 23;25(4):862-870

PMID:1549179 - The wee1 protein kinase is required for radiation-induced mitotic delay.

Rowley R et al. Nature 1992 Mar 26;356(6367):353-5

PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36