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protein coding gene - top2 (SPBC1A4.03c) - DNA topoisomerase II

Gene summary

Standard name
top2
Systematic ID
SPBC1A4.03c
Product
DNA topoisomerase II
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
ptr11
UniProt ID
P08096
ORFeome ID
34/34B05
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome II: 1976161..1981267 reverse strand

Annotation

PBO:0003843 - 5.99.1.3

Complementation

PBO:0013816 - functionally complemented by S. cerevisiae TOP2

References:

PBO:0003842 - functionally complements S. cerevisiae TOP2

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Disease association

MONDO:0012243 - B-cell immunodeficiency, distal limb anomalies, and urogenital malformations

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GO biological process

GO:0006325 - chromatin organization

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GO:0006265 - DNA topological change

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GO:0007076 - mitotic chromosome condensation

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GO:0000712 - resolution of meiotic recombination intermediates

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GO cellular component

GO:0000785 - chromatin

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GO:0034506 - chromosome, centromeric core domain

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GO:0000791 - euchromatin

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GO:0000228 - nuclear chromosome

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GO:0005634 - nucleus

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GO molecular function

GO:0005524 - ATP binding

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GO:0016887 - ATP hydrolysis activity

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GO:0003677 - DNA binding

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GO:0003918 - DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity

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GO:0005515 - protein binding

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Modification

MOD:00046 - O-phospho-L-serine

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MOD:00047 - O-phospho-L-threonine

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MOD:00048 - O4'-phospho-L-tyrosine

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MOD:00696 - phosphorylated residue

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MOD:01149 - sumoylated lysine

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MOD:01148 - ubiquitinylated lysine

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Multi-locus phenotype

FYPO:0003145 - abnormal cell cycle arrest in mitotic prophase

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Genotypes:

FYPO:0001352 - abnormal chromatin organization during vegetative growth

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Genotypes:

FYPO:0005350 - abnormal chromatin organization resulting in peripheral chromatin distribution

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Genotypes:

FYPO:0000848 - abnormal chromosome morphology during vegetative growth

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Genotypes:

FYPO:0000214 - abnormal mitotic chromosome condensation

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Genotypes:

FYPO:0000141 - abnormal mitotic sister chromatid segregation

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Genotypes:

FYPO:0004506 - abnormal nucleolar chromatin organization resulting in peripheral chromatin distribution

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Genotypes:

FYPO:0000671 - abnormal rDNA separation

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Genotypes:

FYPO:0004481 - abolished cell population growth at high temperature

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Genotypes:

FYPO:0001683 - abolished mitotic spindle assembly

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Genotypes:

FYPO:0003689 - abolished protein localization to nucleolus, with protein mislocalized to cytoplasm

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Genotypes:

FYPO:0003002 - decreased protein localization to centromere during mitotic metaphase

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Genotypes:

FYPO:0001645 - decreased protein-protein interaction

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Genotypes:

FYPO:0004009 - decreased rRNA transcription

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Genotypes:

FYPO:0004010 - decreased translation of ribosomal proteins during vegetative growth

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Genotypes:

FYPO:0003757 - incomplete mitotic sister chromatid segregation

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Genotypes:

FYPO:0004098 - incomplete mitotic sister chromatid segregation, with phi-shaped DNA mass

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Genotypes:

FYPO:0004011 - increased degradation of ribosomal proteins during vegetative growth

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Genotypes:

FYPO:0006689 - increased insertion/deletion frequency

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Genotypes:

FYPO:0000972 - increased number of Rad52 foci during vegetative growth

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Genotypes:

FYPO:0004255 - inviable elongated mononucleate vegetative cell

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Genotypes:

FYPO:0002061 - inviable vegetative cell population

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Genotypes:

FYPO:0003758 - mitotic spindle elongation without chromosome separation

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Genotypes:

FYPO:0001513 - normal mitotic sister chromatid segregation

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Genotypes:

FYPO:0001357 - normal vegetative cell population growth

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Genotypes:

FYPO:0007566 - premature mitotic chromosome condensation

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Genotypes:

FYPO:0003559 - sensitive to doxorubicin

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Genotypes:

FYPO:0001234 - slow vegetative cell population growth

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Genotypes:

FYPO:0001492 - viable elongated vegetative cell

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Genotypes:

FYPO:0002060 - viable vegetative cell population

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Genotypes:

Protein sequence feature

SO:0001528 - nuclear_localization_signal

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Qualitative gene expression

PomGeneEx:0000011 - RNA level increased

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Quantitative gene expression

PBO:0006310 - protein level

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PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0004583 - abnormal meiotic chromosome condensation

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Genotypes:

FYPO:0000337 - abnormal mitosis

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Genotypes:

FYPO:0004584 - abnormally arrested meiosis I with four spindle pole bodies

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Genotypes:

FYPO:0004481 - abolished cell population growth at high temperature

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Genotypes:

FYPO:0002779 - abolished protein localization to nucleus, with protein mislocalized to cytoplasm, during vegetative growth

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Genotypes:

FYPO:0004418 - cut cell with decreased poly(A)+ mRNA export from nucleus

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Genotypes:

FYPO:0003165 - cut with abnormal chromosome segregation

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Genotypes:

FYPO:0001168 - decreased ATPase activity

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Genotypes:

FYPO:0001961 - decreased DNA topoisomerase II activity

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Genotypes:

FYPO:0003286 - decreased mitotic chromosome condensation

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Genotypes:

FYPO:0004056 - decreased protein localization to nucleus, with protein mislocalized to cytoplasm

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Genotypes:

FYPO:0005343 - decreased rate of mitotic spindle elongation during anaphase B

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Genotypes:

FYPO:0004009 - decreased rRNA transcription

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Genotypes:

FYPO:0001355 - decreased vegetative cell population growth

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Genotypes:

FYPO:0006689 - increased insertion/deletion frequency

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Genotypes:

FYPO:0004580 - increased number of plasmid catenanes

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Genotypes:

FYPO:0000786 - increased plasmid loss

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Genotypes:

FYPO:0000313 - inviable after spore germination, without cell division, with abnormal germ tube morphology

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Genotypes:

FYPO:0001489 - inviable vegetative cell

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Genotypes:

FYPO:0002061 - inviable vegetative cell population

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Genotypes:

FYPO:0000228 - lagging mitotic chromosomes

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Genotypes:

FYPO:0001387 - loss of viability at high temperature

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Genotypes:

FYPO:0006518 - loss of viability in G0

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Genotypes:

FYPO:0003758 - mitotic spindle elongation without chromosome separation

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Genotypes:

FYPO:0002053 - normal DNA topoisomerase II activity

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Genotypes:

FYPO:0007553 - normal G1 to G0 transition

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Genotypes:

FYPO:0005228 - normal growth on doxorubicin

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Genotypes:

FYPO:0003562 - normal horsetail nucleus morphology

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Genotypes:

FYPO:0004602 - normal linear element morphology

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Genotypes:

FYPO:0004367 - normal mitotic spindle assembly

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Genotypes:

FYPO:0006259 - normal mitotic spindle length during metaphase

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Genotypes:

FYPO:0002043 - normal premeiotic DNA replication

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Genotypes:

FYPO:0004397 - normal protein export from nucleus during vegetative growth

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Genotypes:

FYPO:0004121 - normal protein import into nucleus during vegetative growth

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Genotypes:

FYPO:0000838 - normal protein localization to nucleus during vegetative growth

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Genotypes:

FYPO:0003559 - sensitive to doxorubicin

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Genotypes:

FYPO:0003858 - sensitive to etoposide

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Genotypes:

FYPO:0004433 - sensitive to viridicatumtoxin

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Genotypes:

FYPO:0001234 - slow vegetative cell population growth

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Genotypes:

FYPO:0001491 - viable vegetative cell

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Genotypes:

FYPO:0002060 - viable vegetative cell population

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Genotypes:

Taxonomic conservation

PBO:0011067 - conserved in bacteria

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF00204DNA_gyraseBTopo_IIA_bsu_dom2PFAM
PF01751ToprimTOPRIM_domPFAM
PF00521DNA_topoisoIVTopo_IIA_dom_APFAM
PF02518HATPase_cHATPase_domPFAM
PF16898TOPRIM_CTOPRIM_CPFAM
cd00187TOP4cTopo_IIA_dom_ACDD
cd03481TopoIIA_Trans_ScTopoIIACDD
cd16930HATPase_TopII-likeCDD
cd03365TOPRIM_TopoIIATOPRIM_TopoIICDD
PS00177TOPOISOMERASE_IITopoIIA_CSPROSITE_PATTERNS
PS52040TOPO_IIATopo_IIA_dom_APROSITE_PROFILES
PS50880TOPRIMTOPRIM_domPROSITE_PROFILES
SM00434topIV4Topo_IIA_dom_ASMART
SM00433topII5Topo_IIASMART
SM00387HKATPase_4HATPase_domSMART
PR01158TOPISMRASEIITopoII_eukPRINTS
PR00418TPI2FAMILYPRINTS
G3DSA:3.90.199.10:FF:000002FUNFAM
G3DSA:3.30.230.10:FF:000008FUNFAM
G3DSA:3.40.50.670:FF:000001FUNFAM
G3DSA:3.30.565.10:FF:000004FUNFAM
G3DSA:3.30.1490.30:FF:000001FUNFAM
G3DSA:3.30.1360.40:FF:000003FUNFAM
SSF56719Type II DNA topoisomeraseTopo_IIA-like_dom_sfSUPERFAMILY
SSF55874ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinaseHATPase_C_sfSUPERFAMILY
SSF54211Ribosomal protein S5 domain 2-likeRibosomal_Su5_D2-typ_SFSUPERFAMILY
G3DSA:3.30.1360.40GENE3D
G3DSA:3.40.50.670Topo_IIA_B_CGENE3D
G3DSA:3.30.230.10Ribsml_uS5_D2-typ_fold_subgrGENE3D
G3DSA:3.90.199.10Topoisomerase II, domain 5Topo_IIA_A/C_abGENE3D
G3DSA:3.30.565.10HATPase_C_sfGENE3D
G3DSA:1.10.268.10Topoisomerase, domain 3Topo_IIA_A_a_sfGENE3D
G3DSA:3.30.1490.30GENE3D
PTHR10169DNA TOPOISOMERASE/GYRASEDNA_Topoisomerase_IIPANTHER
CoilCoilCOILS
mobidb-lite-Disorderdisorder_predictionMOBIDB-Disorder
mobidb-lite-Low-complexitydisorder_predictionMOBIDB-Low-complexity
mobidb-lite-Negative-Polyelectrolytedisorder_predictionMOBIDB-Negative-Polyelectrolyte
mobidb-lite-Polardisorder_predictionMOBIDB-Polar
mobidb-lite-Polyampholytedisorder_predictionMOBIDB-Polyampholyte
mobidb-lite-Positive-Polyelectrolytedisorder_predictionMOBIDB-Positive-Polyelectrolyte

Orthologs

References / Literature

PMID:21540296 - Condensin phosphorylated by the Aurora-B-like kinase Ark1 is continuously required until telophase in a mode distinct from Top2.
Nakazawa N et al. J Cell Sci 2011 Jun 01;124(Pt 11):1795-807
PMID:26537787 - Targeting of SUMO substrates to a Cdc48-Ufd1-Npl4 segregase and STUbL pathway in fission yeast.
Køhler JB et al. Nat Commun 2015 Nov 05;6:8827
PMID:7957061 - Fission yeast cut3 and cut14, members of a ubiquitous protein family, are required for chromosome condensation and segregation in mitosis.
Saka Y et al. EMBO J 1994 Oct 17;13(20):4938-52
PMID:38285941 - Specialized replication of heterochromatin domains ensures self-templated chromatin assembly and epigenetic inheritance.
Nathanailidou P et al. Proc Natl Acad Sci U S A 2024 Feb 06;121(6):e2315596121
PMID:25669599 - Fitness profiling links topoisomerase II regulation of centromeric integrity to doxorubicin resistance in fission yeast.
Nguyen TT et al. Sci Rep 2015 Feb 11;5:8400
PMID:18257517 - Phosphoproteome analysis of fission yeast.
Wilson-Grady JT et al. J Proteome Res 2008 Mar;7(3):1088-97
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.
Halova L et al. Open Biol 2021 Apr;11(4):200405
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:10712506 - Mechanisms of sod2 gene amplification in Schizosaccharomyces pombe.
Albrecht EB et al. Mol Biol Cell 2000 Mar;11(3):873-86
PMID:9490640 - A NIMA homologue promotes chromatin condensation in fission yeast.
Krien MJ et al. J Cell Sci 1998 Apr;111 ( Pt 7):967-76
PMID:21712547 - Mitotic substrates of the kinase aurora with roles in chromatin regulation identified through quantitative phosphoproteomics of fission yeast.
Koch A et al. Sci Signal 2011 Jun 28;4(179):rs6
PMID:35320724 - Cdc48 influence on separase levels is independent of mitosis and suggests translational sensitivity of separase.
Vijayakumari D et al. Cell Rep 2022 Mar 22;38(12):110554
GO_REF:0000002 - Comments
PMID:22540037 - Predicting the fission yeast protein interaction network.
Pancaldi V et al. G3 (Bethesda) 2012 Apr;2(4):453-67
PMID:29996109 - Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe.
Swaffer MP et al. Cell Rep 2018 Jul 10;24(2):503-514
PMID:27984725 - CDK Substrate Phosphorylation and Ordering the Cell Cycle.
Swaffer MP et al. Cell 2016 Dec 15;167(7):1750-1761.e16
PMID:16096639 - Taz1, Rap1 and Rif1 act both interdependently and independently to maintain telomeres.
Miller KM et al. EMBO J 2005 Sep 07;24(17):3128-35
PMID:2827111 - Cloning and sequencing of Schizosaccharomyces pombe DNA topoisomerase I gene, and effect of gene disruption.
Uemura T et al. Nucleic Acids Res 1987 Dec 10;15(23):9727-39
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:15161942 - The nucleolus is involved in mRNA export from the nucleus in fission yeast.
Ideue T et al. J Cell Sci 2004 Jun 15;117(Pt 14):2887-95
PMID:26404184 - High Confidence Fission Yeast SUMO Conjugates Identified by Tandem Denaturing Affinity Purification.
Nie M et al. Sci Rep 2015 Sep 25;5:14389
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:27266525 - Nucleosome eviction in mitosis assists condensin loading and chromosome condensation.
Toselli-Mollereau E et al. EMBO J 2016 Jul 15;35(14):1565-81
PMID:2839305 - Deficiency in both type I and type II DNA topoisomerase activities differentially affect rRNA and ribosomal protein synthesis in Schizosaccharomyces pombe.
Yamagishi M et al. Curr Genet 1988 Apr;13(4):305-14
PMID:34738170 - Overexpression of cell-wall GPI-anchored proteins restores cell growth of N-glycosylation-defective och1 mutants in Schizosaccharomyces pombe.
Fukunaga T et al. Appl Microbiol Biotechnol 2021 Dec;105(23):8771-8781
PMID:8388878 - Cell cycle-dependent specific positioning and clustering of centromeres and telomeres in fission yeast.
Funabiki H et al. J Cell Biol 1993 Jun;121(5):961-76
PMID:30635402 - Casein kinase II-dependent phosphorylation of DNA topoisomerase II suppresses the effect of a catalytic topo II inhibitor, ICRF-193, in fission yeast.
Nakazawa N et al. J Biol Chem 2019 Mar 08;294(10):3772-3782
PMID:24013502 - Epe1 recruits BET family bromodomain protein Bdf2 to establish heterochromatin boundaries.
Wang J et al. Genes Dev 2013 Sep 01;27(17):1886-902
PMID:16537923 - Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.
Todd BL et al. Mol Cell Biol 2006 Apr;26(7):2817-31
PMID:8395535 - Identification of seven new cut genes involved in Schizosaccharomyces pombe mitosis.
Samejima I et al. J Cell Sci 1993 May;105 ( Pt 1):135-43
PMID:19547744 - Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.
Beltrao P et al. PLoS Biol 2009 Jun 16;7(6):e1000134
PMID:20495382 - SMC complexes and topoisomerase II work together so that sister chromatids can work apart.
Tapia-Alveal C et al. Cell Cycle 2010 Jun 01;9(11):2065-70
PMID:1658625 - A functional 125-kDa core polypeptide of fission yeast DNA topoisomerase II.
Shiozaki K et al. Mol Cell Biol 1991 Dec;11(12):6093-102
PMID:18204818 - Identification of small molecules inducing apoptosis by cell-based assay using fission yeast deletion mutants.
Chung KS et al. Invest New Drugs 2008 Aug;26(4):299-307
PMID:16453724 - Isolation and characterization of Schizosaccharomyces pombe cutmutants that block nuclear division but not cytokinesis.
Hirano T et al. EMBO J 1986 Nov;5(11):2973-9
PMID:19528228 - Smc5-Smc6-dependent removal of cohesin from mitotic chromosomes.
Outwin EA et al. Mol Cell Biol 2009 Aug;29(16):4363-75
PMID:39476757 - Characterization of Ksg1 protein kinase-dependent phosphoproteome in the fission yeast S. pombe.
Cipak L et al. Biochem Biophys Res Commun 2024 Oct 25;736:150895
PMID:2436053 - Need for DNA topoisomerase activity as a swivel for DNA replication for transcription of ribosomal RNA.
Brill SJ et al. Nature 1987 Mar 26;326(6111):414-6
PMID:2537310 - Essential roles of the RNA polymerase I largest subunit and DNA topoisomerases in the formation of fission yeast nucleolus.
Hirano T et al. J Cell Biol 1989 Feb;108(2):243-53
PMID:25847133 - RNA pol II transcript abundance controls condensin accumulation at mitotically up-regulated and heat-shock-inducible genes in fission yeast.
Nakazawa N et al. Genes Cells 2015 Jun;20(6):481-99
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:9763441 - The role of topoisomerase II in meiotic chromosome condensation and segregation in Schizosaccharomyces pombe.
Hartsuiker E et al. Mol Biol Cell 1998 Oct;9(10):2739-50
PMID:21340088 - Microarray-based target identification using drug hypersensitive fission yeast expressing ORFeome.
Arita Y et al. Mol Biosyst 2011 May;7(5):1463-72
PMID:19111658 - HP1 proteins form distinct complexes and mediate heterochromatic gene silencing by nonoverlapping mechanisms.
Motamedi MR et al. Mol Cell 2008 Dec 26;32(6):778-90
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:19443688 - Diverse roles of HP1 proteins in heterochromatin assembly and functions in fission yeast.
Fischer T et al. Proc Natl Acad Sci U S A 2009 Jun 02;106(22):8998-9003
PMID:1332977 - Functional dissection of the phosphorylated termini of fission yeast DNA topoisomerase II.
Shiozaki K et al. J Cell Biol 1992 Dec;119(5):1023-36
PMID:27298342 - Identification of S-phase DNA damage-response targets in fission yeast reveals conservation of damage-response networks.
Willis NA et al. Proc Natl Acad Sci U S A 2016 Jun 28;113(26):E3676-85
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.
Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:28343969 - Pds5 Regulates Sister-Chromatid Cohesion and Chromosome Bi-orientation through a Conserved Protein Interaction Module.
Goto Y et al. Curr Biol 2017 Apr 03;27(7):1005-1012
PMID:28552615 - SUMO-Targeted DNA Translocase Rrp2 Protects the Genome from Top2-Induced DNA Damage.
Wei Y et al. Mol Cell 2017 Jun 01;66(5):581-596.e6
GO_REF:0000111 - Gene Ontology annotations Inferred by Curator (IC) using at least one Inferred by Sequence Similarity (ISS) annotation to support the inference
PMID:6090122 - Isolation of type I and II DNA topoisomerase mutants from fission yeast: single and double mutants show different phenotypes in cell growth and chromatin organization.
Uemura T et al. EMBO J 1984 Aug;3(8):1737-44
PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.
Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963
PMID:11927555 - The fission yeast NIMA kinase Fin1p is required for spindle function and nuclear envelope integrity.
Krien MJ et al. EMBO J 2002 Apr 02;21(7):1713-22
PMID:15957215 - Mitotic spindle pulls but fails to separate chromosomes in type II DNA topoisomerase mutants: uncoordinated mitosis.
Uemura T et al. EMBO J 1986 May;5(5):1003-10
PMID:26167880 - SR protein kinases promote splicing of nonconsensus introns.
Lipp JJ et al. Nat Struct Mol Biol 2015 Aug;22(8):611-7
PMID:33260998 - High-Throughput Flow Cytometry Combined with Genetic Analysis Brings New Insights into the Understanding of Chromatin Regulation of Cellular Quiescence.
Zahedi Y et al. Int J Mol Sci 2020 Nov 27;21(23)
PMID:3023070 - The nucleotide sequence of the fission yeast DNA topoisomerase II gene: structural and functional relationships to other DNA topoisomerases.
Uemura T et al. EMBO J 1986 Sep;5(9):2355-61
GO_REF:0000051 - S. pombe keyword mapping
PMID:12620220 - The telomere protein Taz1 is required to prevent and repair genomic DNA breaks.
Miller KM et al. Mol Cell 2003 Feb;11(2):303-13
PMID:19150433 - Distinct requirements for the Rad32(Mre11) nuclease and Ctp1(CtIP) in the removal of covalently bound topoisomerase I and II from DNA.
Hartsuiker E et al. Mol Cell 2009 Jan 16;33(1):117-23
PMID:23263988 - Quantitative analysis of chromosome condensation in fission yeast.
Petrova B et al. Mol Cell Biol 2013 Mar;33(5):984-98
PMID:3040264 - DNA topoisomerase II is required for condensation and separation of mitotic chromosomes in S. pombe.
Uemura T et al. Cell 1987 Sep 11;50(6):917-25
PMID:31883795 - Positioning Heterochromatin at the Nuclear Periphery Suppresses Histone Turnover to Promote Epigenetic Inheritance.
Holla S et al. Cell 2020 Jan 09;180(1):150-164.e15
PMID:24362309 - A genetic screen for functional partners of condensin in fission yeast.
Robellet X et al. G3 (Bethesda) 2014 Feb 19;4(2):373-81
PMID:28382430 - DNA Topoisomerase II modulates acetyl-regulation of cohesin-mediated chromosome dynamics.
Lin SJ et al. Curr Genet 2017 Oct;63(5):923-930
PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.
Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:21767457 - DNA topoisomerase 2 mutant allele mildly delays the mitotic progression and activates the checkpoint protein kinase Chk1 in fission yeast Schizosaccharomyces pombe.
Yadav S et al. Genet Res (Camb) 2011 Aug;93(4):275-83
PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.
Strachan J et al. J Cell Sci 2023 Dec 01;136(23)
PMID:9802907 - Dynamics of centromeres during metaphase-anaphase transition in fission yeast: Dis1 is implicated in force balance in metaphase bipolar spindle.
Nabeshima K et al. Mol Biol Cell 1998 Nov;9(11):3211-25
PMID:10473635 - Rad18 is required for DNA repair and checkpoint responses in fission yeast.
Verkade HM et al. Mol Biol Cell 1999 Sep;10(9):2905-18
PMID:24687850 - H2A.Z-dependent regulation of cohesin dynamics on chromosome arms.
Tapia-Alveal C et al. Mol Cell Biol 2014 Jun;34(11):2092-104