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protein coding gene - tam41 (SPBC1A4.06c) - mitochondrial phosphatidate cytidylyltransferase Tam41

Gene summary

Standard name
tam41
Systematic ID
SPBC1A4.06c
Product
mitochondrial phosphatidate cytidylyltransferase Tam41
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
O74339
ORFeome ID
44/44B06
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome II: 1986826..1988447 reverse strand

Annotation

Disease association

MONDO:0859323 - combined oxidative phosphorylation deficiency 56

References:

GO biological process

GO:0032049 - cardiolipin biosynthetic process

References:

GO:0016024 - CDP-diacylglycerol biosynthetic process

References:

GO:0007006 - mitochondrial membrane organization

References:

GO cellular component

GO:0031314 - extrinsic component of mitochondrial inner membrane

References:

GO:0005759 - mitochondrial matrix

References:

GO molecular function

GO:1901612 - cardiolipin binding

References:

GO:0004605 - phosphatidate cytidylyltransferase activity

References:

GO:0070300 - phosphatidic acid binding

References:

Protein sequence feature

SO:0001808 - mitochondrial_targeting_signal

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0000664 - abolished catalytic activity

References:

Genotypes:

FYPO:0007253 - abolished membrane lipid binding

References:

Genotypes:

FYPO:0007252 - decreased membrane lipid binding

References:

Genotypes:

FYPO:0002111 - inviable tapered vegetative cell

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Warnings

PBO:0000108 - frameshifted

References:

PBO:0091753 - II:g.1987102delG

References:

PBO:0091754 - II:g.1987118delG

References:

PBO:0000129 - sequence error in genomic data

References:

Protein features

IDNameInterPro nameDB name
PF09139Tam41_Mmp37Tam41Pfam
PTHR13619Tam41PANTHER
PIRSF028840Mmp37Tam41PIRSF

Orthologs

References / Literature

GO_REF:0000111 - Gene Ontology annotations Inferred by Curator (IC) using at least one Inferred by Sequence Similarity (ISS) annotation to support the inference
PMID:36408920 - UniProt: the Universal Protein Knowledgebase in 2023.
UniProt Consortium Nucleic Acids Res 2023 Jan 06;51(D1):D523-D531
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:31178220 - Structures of the Mitochondrial CDP-DAG Synthase Tam41 Suggest a Potential Lipid Substrate Pathway from Membrane to the Active Site.
Jiao H et al. Structure 2019 Aug 06;27(8):1258-1269.e4
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:34706246 - Cross talk between the upstream exon-intron junction and Prp2 facilitates splicing of non-consensus introns.
Hümmer S et al. Cell Rep 2021 Oct 26;37(4):109893
PMID:26615217 - Bulk Segregant Analysis Reveals the Genetic Basis of a Natural Trait Variation in Fission Yeast.
Hu W et al. Genome Biol Evol 2015 Nov 27;7(12):3496-510
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:31474649 - Identification of 15 New Bypassable Essential Genes of Fission Yeast.
Takeda A et al. Cell Struct Funct 2019 Sep 27;44(2):113-119