protein coding gene - med14 (SPBC1A4.10c) - mediator complex subunit Med14

Gene summary

Standard name

med14

Systematic ID

SPBC1A4.10c

Product

mediator complex subunit Med14

Organism

Schizosaccharomyces pombe (fission yeast)

Synonyms

pmc1, SPBP23A10.01c

UniProt ID

Q9P7Y4

ORFeome ID

33/33H06

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome II: 1996006..1999093 reverse strand

Annotation

Protein features

Orthologs

• MED14 (HGNC:2370) Homo sapiens
• med14 (SJAG_03573) Schizosaccharomyces japonicus
• RGR1 (YLR071C) Saccharomyces cerevisiae

References / Literature

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:23271606 - Fission yeast TOR signaling is essential for the down-regulation of a hyperactivated stress-response MAP kinase under salt stress.

Ishiguro J et al. Mol Genet Genomics 2013 Feb;288(1-2):63-75

PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36

GO_REF:0000033 - Annotation inferences using phylogenetic trees

PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.

Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323

PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.

Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399

PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.

Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704

PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.

Strachan J et al. J Cell Sci 2023 Dec 01;136(23)

PMID:19168988 - Characterization of a fission yeast P(5)-type ATPase homologue that is essential for Ca(2+)/Mn(2+ )homeostasis in the absence of P(2)-type ATPases.

Furune T et al. Genes Genet Syst 2008 Oct;83(5):373-81

PMID:11572939 - Analysis of Schizosaccharomyces pombe mediator reveals a set of essential subunits conserved between yeast and metazoan cells.

Spåhr H et al. Proc Natl Acad Sci U S A 2001 Oct 09;98(21):11985-90

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.

Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7

PMID:18818364 - Conservation and rewiring of functional modules revealed by an epistasis map in fission yeast.

Roguev A et al. Science 2008 Oct 17;322(5900):405-10

PMID:15182371 - Mediator is required for activated transcription in a Schizosaccharomyces pombe in vitro system.

Tamayo E et al. Eur J Biochem 2004 Jun;271(12):2561-72

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:20622008 - A chromatin-remodeling protein is a component of fission yeast mediator.

Khorosjutina O et al. J Biol Chem 2010 Sep 24;285(39):29729-37

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:28241144 - Mediator structure and rearrangements required for holoenzyme formation.

Tsai KL et al. Nature 2017 Apr 13;544(7649):196-201

PMID:28467824 - Core Mediator structure at 3.4 Å extends model of transcription initiation complex.

Nozawa K et al. Nature 2017 May 11;545(7653):248-251

PMID:24463365 - Systematic screen for mutants resistant to TORC1 inhibition in fission yeast reveals genes involved in cellular ageing and growth.

Rallis C et al. Biol Open 2014 Feb 15;3(2):161-71