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protein coding gene - scr1 (SPBC1D7.02c) - DNA-binding transcription repressor, glucose sensing, Scr1

Gene summary

Standard name
scr1
Systematic ID
SPBC1D7.02c
Product
DNA-binding transcription repressor, glucose sensing, Scr1
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
SPBC1D7.02
UniProt ID
O14335
ORFeome ID
39/39E12
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome II: 1752093..1755619 forward strand

Annotation

GO biological process

GO:0060257 - negative regulation of flocculation

References:

GO:0000122 - negative regulation of transcription by RNA polymerase II

References:

GO cellular component

GO:0005737 - cytoplasm

References:

GO:0005829 - cytosol

References:

GO:0005654 - nucleoplasm

References:

GO:0005634 - nucleus

References:

GO molecular function

GO:0001227 - DNA-binding transcription repressor activity, RNA polymerase II-specific

References:

GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding

References:

Modification

MOD:00046 - O-phospho-L-serine

References:

MOD:00047 - O-phospho-L-threonine

References:

MOD:01455 - O-phosphorylated residue

References:

MOD:00048 - O4'-phospho-L-tyrosine

References:

MOD:00696 - phosphorylated residue

References:

Multi-locus phenotype

FYPO:0001355 - decreased vegetative cell population growth

References:

Genotypes:

FYPO:0009111 - increased flocculation during vegetative growth

References:

Genotypes:

Protein features

PBO:0111745 - zf-C2H2 type

PBO:0111743 - zinc finger protein

Qualitative gene expression

PomGeneEx:0000011 - RNA level increased

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0009112 - abolished flocculation during vegetative growth

References:

Genotypes:

FYPO:0000046 - decreased cell population growth

References:

Genotypes:

FYPO:0005742 - decreased invertase activity during glucose starvation

References:

Genotypes:

FYPO:0005288 - decreased negative regulation of transcription by glucose

References:

Genotypes:

FYPO:0005746 - decreased protein export from nucleus during glucose starvation

References:

Genotypes:

FYPO:0005749 - decreased protein phosphorylation during glucose starvation

References:

Genotypes:

FYPO:0001117 - decreased RNA level during vegetative growth

References:

Genotypes:

FYPO:0009111 - increased flocculation during vegetative growth

References:

Genotypes:

FYPO:0000796 - increased glycerol dehydrogenase activity

References:

Genotypes:

FYPO:0007674 - increased invertase activity

References:

Genotypes:

FYPO:0000825 - increased RNA level during vegetative growth

References:

Genotypes:

FYPO:0005743 - normal invertase activity during glucose starvation

References:

Genotypes:

FYPO:0005748 - normal protein export from nucleus during glucose starvation

References:

Genotypes:

FYPO:0001317 - normal RNA level during vegetative growth

References:

Genotypes:

FYPO:0001357 - normal vegetative cell population growth

References:

Genotypes:

FYPO:0000064 - resistance to 2-deoxyglucose

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011063 - conserved in fungi only

Protein features

IDNameInterPro nameDB name
PF00096zf-C2H2Znf_C2H2_typePFAM
PS00028ZINC_FINGER_C2H2_1Znf_C2H2_typePROSITE_PATTERNS
PS50157ZINC_FINGER_C2H2_2Znf_C2H2_typePROSITE_PROFILES
SM00355c2h2final6Znf_C2H2_typeSMART
G3DSA:3.30.160.60:FF:000089FUNFAM
G3DSA:3.30.160.60:FF:000152FUNFAM
SSF57667beta-beta-alpha zinc fingersZnf_C2H2_sfSUPERFAMILY
G3DSA:3.30.160.60Classic Zinc FingerGENE3D
PTHR47428REGULATORY PROTEIN MIG1-RELATEDPANTHER
mobidb-lite-Disorderdisorder_predictionMOBIDB-Disorder
mobidb-lite-Low-complexitydisorder_predictionMOBIDB-Low-complexity
mobidb-lite-Polardisorder_predictionMOBIDB-Polar

Orthologs

References / Literature

PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:27984725 - CDK Substrate Phosphorylation and Ordering the Cell Cycle.
Swaffer MP et al. Cell 2016 Dec 15;167(7):1750-1761.e16
PMID:22098069 - Identification of a galactose-specific flocculin essential for non-sexual flocculation and filamentous growth in Schizosaccharomyces pombe.
Matsuzawa T et al. Mol Microbiol 2011 Dec;82(6):1531-44
PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.
Skribbe M et al. Mol Cell 2025 Feb 19;
PMID:41154583 - Mitochondrial Translation Inhibition Triggers an Rst2-Controlled Transcriptional Reprogramming of Carbon Metabolism in Stationary-Phase Cells of Fission Yeast.
Luo Y et al. Biomolecules 2025 Sep 24;15(10)
PMID:22140232 - Snf1-like protein kinase Ssp2 regulates glucose derepression in Schizosaccharomyces pombe.
Matsuzawa T et al. Eukaryot Cell 2012 Feb;11(2):159-67
PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.
Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87
PMID:26167880 - SR protein kinases promote splicing of nonconsensus introns.
Lipp JJ et al. Nat Struct Mol Biol 2015 Aug;22(8):611-7
PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.
Halova L et al. Open Biol 2021 Apr;11(4):200405
PMID:35924983 - Genetic-interaction screens uncover novel biological roles and regulators of transcription factors in fission yeast.
Chatfield-Reed K et al. G3 (Bethesda) 2022 Aug 25;12(9)
PMID:11238405 - Transcriptional regulators of the Schizosaccharomyces pombe fbp1 gene include two redundant Tup1p-like corepressors and the CCAAT binding factor activation complex.
Janoo RT et al. Genetics 2001 Mar;157(3):1205-15
PMID:25411338 - Mechanisms of expression and translocation of major fission yeast glucose transporters regulated by CaMKK/phosphatases, nuclear shuttling, and TOR.
Saitoh S et al. Mol Biol Cell 2015 Jan 15;26(2):373-86
PMID:29214404 - The 19S proteasome regulates subtelomere silencing and facultative heterochromatin formation in fission yeast.
Seo HD et al. Curr Genet 2018 Jun;64(3):741-752
PMID:19547744 - Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.
Beltrao P et al. PLoS Biol 2009 Jun 16;7(6):e1000134
PMID:20396879 - The gld1+ gene encoding glycerol dehydrogenase is required for glycerol metabolism in Schizosaccharomyces pombe.
Matsuzawa T et al. Appl Microbiol Biotechnol 2010 Jun;87(2):715-27
PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.
Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963
PMID:28515144 - Transient activation of fission yeast AMPK is required for cell proliferation during osmotic stress.
Schutt KL et al. Mol Biol Cell 2017 Jul 01;28(13):1804-1814
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.
Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:36794724 - Cellular responses to long-term phosphate starvation of fission yeast: Maf1 determines fate choice between quiescence and death associated with aberrant tRNA biogenesis.
Garg A et al. Nucleic Acids Res 2023 Apr 24;51(7):3094-3115
PMID:39476757 - Characterization of Ksg1 protein kinase-dependent phosphoproteome in the fission yeast S. pombe.
Cipak L et al. Biochem Biophys Res Commun 2024 Oct 25;736:150895
PMID:30922219 - A genome-wide analysis of carbon catabolite repression in Schizosaccharomyces pombe.
Vassiliadis D et al. BMC Genomics 2019 Mar 29;20(1):251
PMID:9535817 - Isolation and characterization of an invertase and its repressor genes from Schizosaccharomyces pombe.
Tanaka N et al. Biochem Biophys Res Commun 1998 Apr 07;245(1):246-53
PMID:27298342 - Identification of S-phase DNA damage-response targets in fission yeast reveals conservation of damage-response networks.
Willis NA et al. Proc Natl Acad Sci U S A 2016 Jun 28;113(26):E3676-85
PMID:23695302 - Functional characterization of fission yeast transcription factors by overexpression analysis.
Vachon L et al. Genetics 2013 Aug;194(4):873-84
PMID:28218250 - Chromatin remodeller Fun30 Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.
Lee J et al. Nat Commun 2017 Feb 20;8:14527
PMID:29996109 - Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe.
Swaffer MP et al. Cell Rep 2018 Jul 10;24(2):503-514
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:36358992 - Multi-Layered Regulations on the Chromatin Architectures: Establishing the Tight and Specific Responses of Fission Yeast fbp1 Gene Transcription.
Asada R et al. Biomolecules 2022 Nov 05;12(11)