protein coding gene - rtp1 (SPBC20F10.08c) - RNA polymerase II nuclear import protein Rtp1

Gene summary

Standard name: rtp1
Systematic ID: SPBC20F10.08c
Product: RNA polymerase II nuclear import protein Rtp1
Organism: Schizosaccharomyces pombe (fission yeast)
UniProt ID: O42977
ORFeome ID: 28/28A09
Characterisation status: biological role inferred
Feature type: mRNA gene
Genomic location: chromosome II: 3297527..3301262 reverse strand

Annotation

GO biological process

GO:0006606 - protein import into nucleus

References:

GO_REF:0000024

GO cellular component

GO:0005829 - cytosol

References:

PMID:16823372

GO:0005634 - nucleus

References:

PMID:16823372

Modification

MOD:01148 - ubiquitinylated lysine

References:

PMID:37970674

Protein features

PBO:0111765 - HEAT repeat

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

PMID:23101633

Single locus phenotype

FYPO:0002230 - inviable swollen curved vegetative cell

References:

PMID:23697806

Genotypes:

rtp1delta

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

rtp1delta

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

ID	Name	InterPro name	DB name
PF10363	RTP1_C1	Rtp1_C1	PFAM
SSF48371	ARM repeat	ARM-type_fold	SUPERFAMILY
G3DSA:1.25.10.10		ARM-like	GENE3D
PTHR20959	TRANSPORT AND GOLGI ORGANIZATION PROTEIN 6 FAMILY MEMBER	TANGO6/Rtp1	PANTHER

Orthologs

TANGO6 (HGNC:25749) Homo sapiens
rtp1 (SJAG_01328) Schizosaccharomyces japonicus
RTP1 (YMR185W) Saccharomyces cerevisiae

References / Literature

PMID:21511999 - Comparative functional genomics of the fission yeasts.: Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.: Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.: Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.: Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).: Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:32059768 - Size-Dependent Increase in RNA Polymerase II Initiation Rates Mediates Gene Expression Scaling with Cell Size.: Sun XM et al. Curr Biol 2020 Apr 06;30(7):1217-1230.e7
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.: Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.: Strachan J et al. J Cell Sci 2023 Dec 01;136(23)
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.