protein coding gene - med8 (SPBC21.04) - mediator complex subunit Med8

Gene summary

Standard name

med8

Systematic ID

SPBC21.04

Product

mediator complex subunit Med8

Organism

Schizosaccharomyces pombe (fission yeast)

Synonyms

sep15

UniProt ID

O94646

ORFeome ID

43/43A10

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome II: 3219405..3222152 forward strand

Annotation

Protein features

Orthologs

• MED8 (HGNC:19971) Homo sapiens
• med8 (SJAG_03622) Schizosaccharomyces japonicus
• MED8 (YBR193C) Saccharomyces cerevisiae

References / Literature

PMID:28241144 - Mediator structure and rearrangements required for holoenzyme formation.

Tsai KL et al. Nature 2017 Apr 13;544(7649):196-201

PMID:10392445 - Eleven novel sep genes of Schizosaccharomyces pombe required for efficient cell separation and sexual differentiation.

Grallert A et al. Yeast 1999 Jun 15;15(8):669-86

PMID:11572939 - Analysis of Schizosaccharomyces pombe mediator reveals a set of essential subunits conserved between yeast and metazoan cells.

Spåhr H et al. Proc Natl Acad Sci U S A 2001 Oct 09;98(21):11985-90

PMID:19720063 - The Med8 mediator subunit interacts with the Rpb4 subunit of RNA polymerase II and Ace2 transcriptional activator in Schizosaccharomyces pombe.

Mehta S et al. FEBS Lett 2009 Oct 06;583(19):3115-20

PMID:28467824 - Core Mediator structure at 3.4 Å extends model of transcription initiation complex.

Nozawa K et al. Nature 2017 May 11;545(7653):248-251

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.

Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:15182371 - Mediator is required for activated transcription in a Schizosaccharomyces pombe in vitro system.

Tamayo E et al. Eur J Biochem 2004 Jun;271(12):2561-72

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.

Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7

PMID:23123849 - Structure of the Mediator head module.

Larivière L et al. Nature 2012 Dec 20;492(7429):448-51

PMID:18310102 - Two conserved modules of Schizosaccharomyces pombe Mediator regulate distinct cellular pathways.

Linder T et al. Nucleic Acids Res 2008 May;36(8):2489-504

PMID:12738880 - TRAP230/ARC240 and TRAP240/ARC250 Mediator subunits are functionally conserved through evolution.

Samuelsen CO et al. Proc Natl Acad Sci U S A 2003 May 27;100(11):6422-7

PMID:10625684 - Purification and characterization of RNA polymerase II holoenzyme from Schizosaccharomyces pombe.

Spåhr H et al. J Biol Chem 2000 Jan 14;275(2):1351-6

GO_REF:0000033 - Annotation inferences using phylogenetic trees

PMID:11191205 - The Schizosaccharomyces pombe sep15+ gene encodes a protein homologous to the Med8 subunit of the Saccharomyces cerevisiae transcriptional mediator complex.

Zilahi E et al. Curr Genet 2000 Dec;38(5):227-32

PMID:15829570 - Impairment of the TFIIH-associated CDK-activating kinase selectively affects cell cycle-regulated gene expression in fission yeast.

Lee KM et al. Mol Biol Cell 2005 Jun;16(6):2734-45

PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.

Strachan J et al. J Cell Sci 2023 Dec 01;136(23)

PMID:30355493 - Expanded Interactome of the Intrinsically Disordered Protein Dss1.

Schenstrøm SM et al. Cell Rep 2018 Oct 23;25(4):862-870

Pfam:PF10232 - Unknown title

PMID:19473263 - The involvement of the Schizosaccharomyces pombe sep9/spt8 gene in the regulation of septum cleavage.

Batta G et al. FEMS Yeast Res 2009 Aug;9(5):757-67

PMID:17922236 - Genomic expression patterns in cell separation mutants of Schizosaccharomyces pombe defective in the genes sep10 ( + ) and sep15 ( + ) coding for the Mediator subunits Med31 and Med8.

Miklos I et al. Mol Genet Genomics 2008 Mar;279(3):225-38

PMID:18381891 - Structure-system correlation identifies a gene regulatory Mediator submodule.

Larivière L et al. Genes Dev 2008 Apr 01;22(7):872-7