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protein coding gene - ral2 (SPBC21.05c) - Ras1-Scd pathway protein Ral2

Gene summary

Standard name
ral2
Systematic ID
SPBC21.05c
Product
Ras1-Scd pathway protein Ral2
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
P15258
ORFeome ID
33/33E05
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome II: 3219942..3222337 reverse strand

Annotation

PBO:0000384 - Ras1-Scd

GO biological process

GO:2000784 - positive regulation of establishment of cell polarity regulating cell shape

References:

GO:0031137 - regulation of conjugation with cellular fusion

References:

GO cellular component

GO:0005783 - endoplasmic reticulum

References:

Modification

MOD:00046 - O-phospho-L-serine

References:

Multi-locus phenotype

FYPO:0000708 - decreased mating efficiency

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

FYPO:0000590 - normal sporulation

References:

Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

References:

Genotypes:

Protein features

PBO:0111861 - BTB/POZ domain

PBO:0111882 - kelch repeat protein

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0000708 - decreased mating efficiency

References:

Genotypes:

FYPO:0000584 - decreased sporulation frequency

References:

Genotypes:

FYPO:0002048 - normal cell morphology during nitrogen starvation

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Genotypes:

FYPO:0000551 - pseudohyphal growth abolished

References:

Genotypes:

FYPO:0006680 - sensitive to bisphenol A

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Genotypes:

FYPO:0000280 - sterile

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Genotypes:

FYPO:0000024 - stubby vegetative cell

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Genotypes:

FYPO:0006617 - viable elongated vegetative cell with increased cell diameter

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Genotypes:

FYPO:0002380 - viable spheroid vegetative cell

References:

Genotypes:

FYPO:0002106 - viable stubby vegetative cell

References:

Genotypes:

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

FYPO:0002197 - viable vegetative cell with abnormal cell shape

References:

Genotypes:

FYPO:0006616 - viable vegetative cell with increased cell diameter

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011063 - conserved in fungi only

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF24681Kelch_KLHDC2_KLHL20_DRC7Pfam
G3DSA:3.30.710.10:FF:000142CATH-FunFam
G3DSA:2.120.10.80Kelch-typ_b-propellerCATH-Gene3D
G3DSA:3.30.710.10SKP1/BTB/POZ_sfCATH-Gene3D
SSF117281Kelch-typ_b-propellerSUPERFAMILY
PTHR43503PANTHER

Orthologs

References / Literature

PMID:19542312 - Functional genomics of adhesion, invasion, and mycelial formation in Schizosaccharomyces pombe.
Dodgson J et al. Eukaryot Cell 2009 Aug;8(8):1298-306
PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.
Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323
PMID:9133664 - The Schizosaccharomyces pombe mra1 gene, which is required for cell growth and mating, can suppress the mating inefficiency caused by a deficit in the Ras1 activity.
Hakuno F et al. Genes Cells 1996 Mar;1(3):303-15
PMID:24192486 - The conserved Fanconi anemia nuclease Fan1 and the SUMO E3 ligase Pli1 act in two novel Pso2-independent pathways of DNA interstrand crosslink repair in yeast.
Fontebasso Y et al. DNA Repair (Amst) 2013 Dec;12(12):1011-23
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:26098123 - Promoter nucleosome dynamics regulated by signalling through the CTD code.
Materne P et al. Elife 2015 Jun 22;4:e09008
PMID:8575018 - Two novel genes involved in the sexual development of Schizosaccharomyces pombe.
Molnar M et al. Curr Genet 1995 Oct;28(5):447-53
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:30647105 - Comparative Genomic Screen in Two Yeasts Reveals Conserved Pathways in the Response Network to Phenol Stress.
Alhoch B et al. G3 (Bethesda) 2019 Mar 07;9(3):639-650
PMID:25373780 - A genomic Multiprocess survey of machineries that control and link cell shape, microtubule organization, and cell-cycle progression.
Graml V et al. Dev Cell 2014 Oct 27;31(2):227-239
PMID:18257517 - Phosphoproteome analysis of fission yeast.
Wilson-Grady JT et al. J Proteome Res 2008 Mar;7(3):1088-97
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:2586528 - Characterization of the Schizosaccharomyces pombe ral2 gene implicated in activation of the ras1 gene product.
Fukui Y et al. Mol Cell Biol 1989 Dec;9(12):5617-22
PMID:23950735 - Global analysis of fission yeast mating genes reveals new autophagy factors.
Sun LL et al. PLoS Genet 2013;9(8):e1003715
PMID:3071741 - Isolation and characterization of Schizosaccharomyces pombe mutants phenotypically similar to ras1-.
Fukui Y et al. Mol Gen Genet 1988 Dec;215(1):26-31
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:21849474 - Spatial control of Cdc42 activation determines cell width in fission yeast.
Kelly FD et al. Mol Biol Cell 2011 Oct;22(20):3801-11
PMID:17016471 - Repression of ergosterol level during oxidative stress by fission yeast F-box protein Pof14 independently of SCF.
Tafforeau L et al. EMBO J 2006 Oct 04;25(19):4547-56
PMID:2038319 - Identification of a GTPase-activating protein homolog in Schizosaccharomyces pombe.
Imai Y et al. Mol Cell Biol 1991 Jun;11(6):3088-94
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.
Halova L et al. Open Biol 2021 Apr;11(4):200405