protein coding gene - cdc7 (SPBC21.06c) - SIN signalling serine/threonine protein kinase Cdc7

Gene summary

Standard name

cdc7

Systematic ID

SPBC21.06c

Product

SIN signalling serine/threonine protein kinase Cdc7

Organism

Schizosaccharomyces pombe (fission yeast)

Synonyms

pld1, its10

UniProt ID

P41892

ORFeome ID

41/41A10

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome II: 3222351..3226505 reverse strand

Annotation

Protein features

Orthologs

• cdc7 (SJAG_04468) Schizosaccharomyces japonicus
• CDC15 (YAR019C) Saccharomyces cerevisiae

References / Literature

PMID:11676915 - S. pombe cdc11p, together with sid4p, provides an anchor for septation initiation network proteins on the spindle pole body.

Krapp A et al. Curr Biol 2001 Oct 16;11(20):1559-68

PMID:16141239 - Endocytosis in fission yeast is spatially associated with the actin cytoskeleton during polarised cell growth and cytokinesis.

Gachet Y et al. J Cell Sci 2005 Sep 15;118(Pt 18):4231-42

PMID:1527180 - Genetic interactions in the control of septation in Schizosaccharomyces pombe.

Marks J et al. J Cell Sci 1992 Apr;101 ( Pt 4):801-8

PMID:12791993 - Equatorial retention of the contractile actin ring by microtubules during cytokinesis.

Pardo M et al. Science 2003 Jun 06;300(5625):1569-74

PMID:19942852 - Fission yeast Pcp1 links polo kinase-mediated mitotic entry to gamma-tubulin-dependent spindle formation.

Fong CS et al. EMBO J 2010 Jan 06;29(1):120-30

PMID:10837231 - Mob1p interacts with the Sid2p kinase and is required for cytokinesis in fission yeast.

Hou MC et al. Curr Biol 2000 May 18;10(10):619-22

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:10775265 - The role of the sid1p kinase and cdc14p in regulating the onset of cytokinesis in fission yeast.

Guertin DA et al. EMBO J 2000 Apr 17;19(8):1803-15

PMID:11271422 - Bypass of the requirement for cdc16p GAP function in Schizosaccharomyces pombe by mutation of the septation initiation network genes.

Fournier N et al. Arch Microbiol 2001 Jan;175(1):62-9

PMID:23297348 - Comprehensive proteomics analysis reveals new substrates and regulators of the fission yeast clp1/cdc14 phosphatase.

Chen JS et al. Mol Cell Proteomics 2013 May;12(5):1074-86

PMID:16325501 - The fission yeast MO25 protein functions in polar growth and cell separation.

Mendoza M et al. Eur J Cell Biol 2005 Dec;84(12):915-26

PMID:10462526 - The S. pombe zfs1 gene is required to prevent septation if mitotic progression is inhibited.

Beltraminelli N et al. J Cell Sci 1999 Sep;112 Pt 18:3103-14

PMID:23093943 - Cytokinesis-based constraints on polarized cell growth in fission yeast.

Bohnert KA et al. PLoS Genet 2012;8(10):e1003004

PMID:22419817 - The fission yeast septation initiation network (SIN) kinase, Sid2, is required for SIN asymmetry and regulates the SIN scaffold, Cdc11.

Feoktistova A et al. Mol Biol Cell 2012 May;23(9):1636-45

PMID:15933715 - Etd1p is a novel protein that links the SIN cascade with cytokinesis.

Daga RR et al. EMBO J 2005 Jul 06;24(13):2436-46

PMID:38865179 - Transient PP2A SIP complex localization to mitotic SPBs for SIN inhibition is mediated solely by the Csc1 FHA domain.

Willet AH et al. Mol Biol Cell 2024 Jun 12;:mbcE24040196

PMID:10799520 - Byr4 localizes to spindle-pole bodies in a cell cycle-regulated manner to control Cdc7 localization and septation in fission yeast.

Li C et al. J Biol Chem 2000 May 12;275(19):14381-7

PMID:11694585 - Interactions among a fimbrin, a capping protein, and an actin-depolymerizing factor in organization of the fission yeast actin cytoskeleton.

Nakano K et al. Mol Biol Cell 2001 Nov;12(11):3515-26

PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.

Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87

PMID:10503548 - Analysis of the cps1 gene provides evidence for a septation checkpoint in Schizosaccharomyces pombe.

Le Goff X et al. Mol Gen Genet 1999 Aug;262(1):163-72

PMID:19547744 - Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.

Beltrao P et al. PLoS Biol 2009 Jun 16;7(6):e1000134

PMID:16224022 - Counting cytokinesis proteins globally and locally in fission yeast.

Wu JQ et al. Science 2005 Oct 14;310(5746):310-4

PMID:35286199 - Mitotic spindle formation in the absence of Polo kinase.

Kim J et al. Proc Natl Acad Sci U S A 2022 Mar 22;119(12):e2114429119

PMID:10769201 - The S. pombe orthologue of the S. cerevisiae mob1 gene is essential and functions in signalling the onset of septum formation.

Salimova E et al. J Cell Sci 2000 May;113 ( Pt 10):1695-704

PMID:11514436 - Correct regulation of the septation initiation network in Schizosaccharomyces pombe requires the activities of par1 and par2.

Jiang W et al. Genetics 2001 Aug;158(4):1413-29

PMID:28218250 - Chromatin remodeller Fun30 Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.

Lee J et al. Nat Commun 2017 Feb 20;8:14527

PMID:10805785 - Sid4p is required to localize components of the septation initiation pathway to the spindle pole body in fission yeast.

Chang L et al. Proc Natl Acad Sci U S A 2000 May 09;97(10):5249-54

PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.

Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105

PMID:24920823 - Cdk1 promotes cytokinesis in fission yeast through activation of the septation initiation network.

Rachfall N et al. Mol Biol Cell 2014 Aug 01;25(15):2250-9

PMID:16866873 - Actin-capping protein is involved in controlling organization of actin cytoskeleton together with ADF/cofilin, profilin and F-actin crosslinking proteins in fission yeast.

Nakano K et al. Genes Cells 2006 Aug;11(8):893-905

PMID:34296454 - The TOR-dependent phosphoproteome and regulation of cellular protein synthesis.

Mak T et al. EMBO J 2021 Aug 16;40(16):e107911

PMID:14602073 - Spatial and temporal pathway for assembly and constriction of the contractile ring in fission yeast cytokinesis.

Wu JQ et al. Dev Cell 2003 Nov;5(5):723-34

PMID:9649519 - Isolation and characterization of new fission yeast cytokinesis mutants.

Balasubramanian MK et al. Genetics 1998 Jul;149(3):1265-75

PMID:12354095 - Calcineurin is implicated in the regulation of the septation initiation network in fission yeast.

Lu Y et al. Genes Cells 2002 Oct;7(10):1009-19

PMID:10545452 - Drc1p/Cps1p, a 1,3-beta-glucan synthase subunit, is essential for division septum assembly in Schizosaccharomyces pombe.

Liu J et al. Genetics 1999 Nov;153(3):1193-203

PMID:9405296 - Genes that cause aberrant cell morphology by overexpression in fission yeast: a role of a small GTP-binding protein Rho2 in cell morphogenesis.

Hirata D et al. J Cell Sci 1998 Jan;111 ( Pt 2):149-59

PMID:12637524 - Zinc finger protein Prz1 regulates Ca2+ but not Cl- homeostasis in fission yeast. Identification of distinct branches of calcineurin signaling pathway in fission yeast.

Hirayama S et al. J Biol Chem 2003 May 16;278(20):18078-84

PMID:20826805 - Fission yeast germinal center (GC) kinase Ppk11 interacts with Pmo25 and plays an auxiliary role in concert with the morphogenesis Orb6 network (MOR) in cell morphogenesis.

Goshima T et al. J Biol Chem 2010 Nov 05;285(45):35196-205

PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36

PMID:39476757 - Characterization of Ksg1 protein kinase-dependent phosphoproteome in the fission yeast S. pombe.

Cipak L et al. Biochem Biophys Res Commun 2024 Oct 25;736:150895

PMID:12456722 - Mob2p interacts with the protein kinase Orb6p to promote coordination of cell polarity with cell cycle progression.

Hou MC et al. J Cell Sci 2003 Jan 01;116(Pt 1):125-35

PMID:22267499 - Characterization of ypa1 and ypa2, the Schizosaccharomyces pombe orthologs of the peptidyl proyl isomerases that activate PP2A, reveals a role for Ypa2p in the regulation of cytokinesis.

Goyal A et al. Genetics 2012 Apr;190(4):1235-50

PMID:21131906 - Dma1 ubiquitinates the SIN scaffold, Sid4, to impede the mitotic localization of Plo1 kinase.

Johnson AE et al. EMBO J 2011 Jan 19;30(2):341-54

PMID:11870208 - F-actin ring formation and the role of F-actin cables in the fission yeast Schizosaccharomyces pombe.

Arai R et al. J Cell Sci 2002 Mar 01;115(Pt 5):887-98

PMID:9420333 - Asymmetric segregation on spindle poles of the Schizosaccharomyces pombe septum-inducing protein kinase Cdc7p.

Sohrmann M et al. Genes Dev 1998 Jan 01;12(1):84-94

PMID:12242222 - The Scw1 RNA-binding domain protein regulates septation and cell-wall structure in fission yeast.

Karagiannis J et al. Genetics 2002 Sep;162(1):45-58

PMID:20805322 - The mitosis-to-interphase transition is coordinated by cross talk between the SIN and MOR pathways in Schizosaccharomyces pombe.

Ray S et al. J Cell Biol 2010 Sep 06;190(5):793-805

PMID:9638658 - Byr4, a dosage-dependent regulator of cytokinesis in S. pombe, interacts with a possible small GTPase pathway including Spg1 and Cdc16.

Jwa M et al. Mol Cells 1998 Apr 30;8(2):240-5

PMID:23862021 - The C-terminus of S. pombe DDK subunit Dfp1 is required for meiosis-specific transcription and cohesin cleavage.

Le AH et al. Biol Open 2013 Jul 15;2(7):728-38

PMID:38938413 - Characterization of temperature-sensitive Schizosaccharomyces pombe mutants in the septation initiation network Spg1 GTPase.

Fletcher AB et al. MicroPubl Biol 2024;2024

PMID:19736319 - Proper timing of cytokinesis is regulated by Schizosaccharomyces pombe Etd1.

García-Cortés JC et al. J Cell Biol 2009 Sep 07;186(5):739-53

PMID:24790095 - Characterization of the roles of Blt1p in fission yeast cytokinesis.

Goss JW et al. Mol Biol Cell 2014 Jul 01;25(13):1946-57

PMID:9203579 - The Spg1p GTPase is an essential, dosage-dependent inducer of septum formation in Schizosaccharomyces pombe.

Schmidt S et al. Genes Dev 1997 Jun 15;11(12):1519-34

PMID:6943408 - Cell division cycle mutants altered in DNA replication and mitosis in the fission yeast Schizosaccharomyces pombe.

Nasmyth K et al. Mol Gen Genet 1981;182(1):119-24

PMID:22543982 - Hsp90 interaction with Cdc2 and Plo1 kinases contributes to actomyosin ring condensation in fission yeast.

Santino A et al. Curr Genet 2012 Aug;58(4):191-203

PMID:21712547 - Mitotic substrates of the kinase aurora with roles in chromatin regulation identified through quantitative phosphoproteomics of fission yeast.

Koch A et al. Sci Signal 2011 Jun 28;4(179):rs6

PMID:16096637 - Fission yeast MO25 protein is localized at SPB and septum and is essential for cell morphogenesis.

Kanai M et al. EMBO J 2005 Sep 07;24(17):3012-25

PMID:12546793 - Mitotic hyperphosphorylation of the fission yeast SIN scaffold protein cdc11p is regulated by the protein kinase cdc7p.

Krapp A et al. Curr Biol 2003 Jan 21;13(2):168-72

PMID:29996109 - Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe.

Swaffer MP et al. Cell Rep 2018 Jul 10;24(2):503-514

PMID:11952833 - The gamma-tubulin complex protein Alp4 provides a link between the metaphase checkpoint and cytokinesis in fission yeast.

Vardy L et al. Genes Cells 2002 Apr;7(4):365-73

PMID:16415366 - A role for the septation initiation network in septum assembly revealed by genetic analysis of sid2-250 suppressors.

Jin QW et al. Genetics 2006 Apr;172(4):2101-12

PMID:20876564 - Antagonistic roles of PP2A-Pab1 and Etd1 in the control of cytokinesis in fission yeast.

Lahoz A et al. Genetics 2010 Dec;186(4):1261-70

PMID:24838944 - Dma1-dependent degradation of SIN proteins during meiosis in Schizosaccharomyces pombe.

Krapp A et al. J Cell Sci 2014 Jul 15;127(Pt 14):3149-61

PMID:10459013 - Sid2p, a spindle pole body kinase that regulates the onset of cytokinesis.

Sparks CA et al. J Cell Biol 1999 Aug 23;146(4):777-90

PMID:35099006 - Fission yeast polycystin Pkd2p promotes cell size expansion and antagonizes the Hippo-related SIN pathway.

Sinha D et al. J Cell Sci 2022 Feb 15;135(4)

PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.

Halova L et al. Open Biol 2021 Apr;11(4):200405

PMID:11707284 - The protein phosphatase 2A B'-regulatory subunit par1p is implicated in regulation of the S. pombe septation initiation network.

Le Goff X et al. FEBS Lett 2001 Nov 09;508(1):136-42

PMID:12479804 - Dma1 prevents mitotic exit and cytokinesis by inhibiting the septation initiation network (SIN).

Guertin DA et al. Dev Cell 2002 Dec;3(6):779-90

PMID:11250892 - The role of Plo1 kinase in mitotic commitment and septation in Schizosaccharomyces pombe.

Tanaka K et al. EMBO J 2001 Mar 15;20(6):1259-70

PMID:27385337 - Roles of the novel coiled-coil protein Rng10 in septum formation during fission yeast cytokinesis.

Liu Y et al. Mol Biol Cell 2016 Aug 15;27(16):2528-41

PMID:7634333 - The S. pombe cdc15 gene is a key element in the reorganization of F-actin at mitosis.

Fankhauser C et al. Cell 1995 Aug 11;82(3):435-44

PMID:12161753 - The transcriptional program of meiosis and sporulation in fission yeast.

Mata J et al. Nat Genet 2002 Sep;32(1):143-7

PMID:11739799 - Localization of fission yeast type II myosin, Myo2, to the cytokinetic actin ring is regulated by phosphorylation of a C-terminal coiled-coil domain and requires a functional septation initiation network.

Mulvihill DP et al. Mol Biol Cell 2001 Dec;12(12):4044-53

PMID:12411492 - Plo1(+) regulates gene transcription at the M-G(1) interval during the fission yeast mitotic cell cycle.

Anderson M et al. EMBO J 2002 Nov 01;21(21):5745-55

PMID:12234926 - Fission yeast Mor2/Cps12, a protein similar to Drosophila Furry, is essential for cell morphogenesis and its mutation induces Wee1-dependent G(2) delay.

Hirata D et al. EMBO J 2002 Sep 16;21(18):4863-74

PMID:15647375 - The roles of fission yeast ase1 in mitotic cell division, meiotic nuclear oscillation, and cytokinesis checkpoint signaling.

Yamashita A et al. Mol Biol Cell 2005 Mar;16(3):1378-95

PMID:16787941 - The Schizosaccharomyces pombe septation initiation network (SIN) is required for spore formation in meiosis.

Krapp A et al. J Cell Sci 2006 Jul 15;119(Pt 14):2882-91

PMID:16467379 - Actin-depolymerizing protein Adf1 is required for formation and maintenance of the contractile ring during cytokinesis in fission yeast.

Nakano K et al. Mol Biol Cell 2006 Apr;17(4):1933-45

PMID:25501814 - The septation initiation network controls the assembly of nodes containing Cdr2p for cytokinesis in fission yeast.

Pu KM et al. J Cell Sci 2015 Feb 01;128(3):441-6

PMID:8039497 - The cdc7 protein kinase is a dosage dependent regulator of septum formation in fission yeast.

Fankhauser C et al. EMBO J 1994 Jul 01;13(13):3011-9

PMID:22119525 - SIN-inhibitory phosphatase complex promotes Cdc11p dephosphorylation and propagates SIN asymmetry in fission yeast.

Singh NS et al. Curr Biol 2011 Dec 06;21(23):1968-78

PMID:20826461 - The role of Schizosaccharomyces pombe dma1 in spore formation during meiosis.

Krapp A et al. J Cell Sci 2010 Oct 01;123(Pt 19):3284-93

PMID:20980623 - A novel role of Dma1 in regulating forespore membrane assembly and sporulation in fission yeast.

Li WZ et al. Mol Biol Cell 2010 Dec;21(24):4349-60

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:8886983 - The fission yeast sts5+ gene is required for maintenance of growth polarity and functionally interacts with protein kinase C and an osmosensing MAP-kinase pathway.

Toda T et al. J Cell Sci 1996 Sep;109 ( Pt 9):2331-42

PMID:18397994 - Slk1 is a meiosis-specific Sid2-related kinase that coordinates meiotic nuclear division with growth of the forespore membrane.

Pérez-Hidalgo L et al. J Cell Sci 2008 May 01;121(Pt 9):1383-92

GO_REF:0000033 - Annotation inferences using phylogenetic trees

PMID:18303049 - Chemical genetic analysis of the regulatory role of Cdc2p in the S. pombe septation initiation network.

Dischinger S et al. J Cell Sci 2008 Mar 15;121(Pt 6):843-53

PMID:16085489 - The 14-3-3 protein rad24p modulates function of the cdc14p family phosphatase clp1p/flp1p in fission yeast.

Mishra M et al. Curr Biol 2005 Aug 09;15(15):1376-83

PMID:16687577 - Cell cycle-dependent roles for the FCH-domain protein Cdc15p in formation of the actomyosin ring in Schizosaccharomyces pombe.

Wachtler V et al. Mol Biol Cell 2006 Jul;17(7):3254-66

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:23966468 - Cooperation between Rho-GEF Gef2 and its binding partner Nod1 in the regulation of fission yeast cytokinesis.

Zhu YH et al. Mol Biol Cell 2013 Oct;24(20):3187-204

PMID:17317928 - A method for Pmo25-associated kinase assay in fission yeast: the activity is dependent on two gC kinases Nak1 and Sid1.

Kume K et al. Biosci Biotechnol Biochem 2007 Feb;71(2):615-7

PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.

Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704

PMID:12796296 - Scw1p antagonizes the septation initiation network to regulate septum formation and cell separation in the fission yeast Schizosaccharomyces pombe.

Jin QW et al. Eukaryot Cell 2003 Jun;2(3):510-20

PMID:10924454 - A new genetic method for isolating functionally interacting genes: high plo1(+)-dependent mutants and their suppressors define genes in mitotic and septation pathways in fission yeast.

Cullen CF et al. Genetics 2000 Aug;155(4):1521-34

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:19486165 - Pleiotropic phenotypes caused by an opal nonsense mutation in an essential gene encoding HMG-CoA reductase in fission yeast.

Fang Y et al. Genes Cells 2009 Jun;14(6):759-71

PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.

Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323

PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.

Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7

PMID:20967237 - Fission yeast cells undergo nuclear division in the absence of spindle microtubules.

Castagnetti S et al. PLoS Biol 2010 Oct 12;8(10):e1000512

PMID:18562696 - The meiosis-specific Sid2p-related protein Slk1p regulates forespore membrane assembly in fission yeast.

Yan H et al. Mol Biol Cell 2008 Sep;19(9):3676-90

PMID:11683392 - Flp1, a fission yeast orthologue of the s. cerevisiae CDC14 gene, is not required for cyclin degradation or rum1p stabilisation at the end of mitosis.

Cueille N et al. J Cell Sci 2001 Jul;114(Pt 14):2649-64

PMID:15743909 - Profilin-mediated competition between capping protein and formin Cdc12p during cytokinesis in fission yeast.

Kovar DR et al. Mol Biol Cell 2005 May;16(5):2313-24

PMID:17496123 - The Schizosaccharomyces pombe Cdc7 protein kinase required for septum formation is a client protein of Cdc37.

Liang J et al. Eukaryot Cell 2007 Jul;6(7):1089-96

PMID:22740629 - α-Actinin and fimbrin cooperate with myosin II to organize actomyosin bundles during contractile-ring assembly.

Laporte D et al. Mol Biol Cell 2012 Aug;23(16):3094-110

PMID:11950932 - The spindle pole body protein Cdc11p links Sid4p to the fission yeast septation initiation network.

Tomlin GC et al. Mol Biol Cell 2002 Apr;13(4):1203-14

PMID:18225957 - Nuc2p, a subunit of the anaphase-promoting complex, inhibits septation initiation network following cytokinesis in fission yeast.

Chew TG et al. PLoS Genet 2008 Jan;4(1):e17

PMID:24055157 - CK1 is required for a mitotic checkpoint that delays cytokinesis.

Johnson AE et al. Curr Biol 2013 Oct 07;23(19):1920-6

PMID:8876193 - Microtubules mediate mitochondrial distribution in fission yeast.

Yaffe MP et al. Proc Natl Acad Sci U S A 1996 Oct 15;93(21):11664-8

PMID:22891259 - Fission yeast Ags1 confers the essential septum strength needed for safe gradual cell abscission.

Cortés JC et al. J Cell Biol 2012 Aug 20;198(4):637-56

PMID:33506191 - Escape from mitotic catastrophe by actin-dependent nuclear displacement in fission yeast.

Yukawa M et al. iScience 2021 Jan 22;24(1):102031

PMID:10381387 - Asymmetry of the spindle pole bodies and spg1p GAP segregation during mitosis in fission yeast.

Cerutti L et al. J Cell Sci 1999 Jul;112 ( Pt 14):2313-21

PMID:16469735 - Identification of functional domains within the septation initiation network kinase, Cdc7.

Mehta S et al. J Biol Chem 2006 Apr 14;281(15):9935-41

PMID:15265986 - The Clp1p/Flp1p phosphatase ensures completion of cytokinesis in response to minor perturbation of the cell division machinery in Schizosaccharomyces pombe.

Mishra M et al. J Cell Sci 2004 Aug 01;117(Pt 17):3897-910