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protein coding gene - gea1 (SPBC211.03c) - ArfGEF

Gene summary

Standard name
gea1
Systematic ID
SPBC211.03c
Product
ArfGEF
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
Q9P7R8
ORFeome ID
30/30G11
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome II: 3875125..3879920 reverse strand

Annotation

Disease association

MONDO:0011675 - Charcot-Marie-Tooth Disease, axonal, type 2GG

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GO biological process

GO:0030036 - actin cytoskeleton organization

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GO:0043001 - Golgi to plasma membrane protein transport

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GO:0006890 - retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum

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GO cellular component

GO:0005737 - cytoplasm

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GO:0005829 - cytosol

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GO:0005794 - Golgi apparatus

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GO:0000139 - Golgi membrane

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GO molecular function

GO:0005085 - guanyl-nucleotide exchange factor activity

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Modification

MOD:00046 - O-phospho-L-serine

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MOD:00047 - O-phospho-L-threonine

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Qualitative gene expression

PomGeneEx:0000018 - protein level increased

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Quantitative gene expression

PBO:0006310 - protein level

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PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0000230 - abnormal actomyosin contractile ring actin filament organization

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Genotypes:

FYPO:0002719 - decreased protein localization to septum

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Genotypes:

FYPO:0000538 - decreased protein secretion during vegetative growth

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Genotypes:

FYPO:0000650 - increased septation index

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Genotypes:

FYPO:0001406 - increased septum thickness

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Genotypes:

FYPO:0002429 - inviable after spore germination, multiple cell divisions, abnormal cell shape, normal cell size

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Genotypes:

FYPO:0002151 - inviable spore

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Genotypes:

FYPO:0002061 - inviable vegetative cell population

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Genotypes:

FYPO:0000123 - large vacuoles during vegetative growth

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Genotypes:

FYPO:0001390 - misoriented septum during vegetative growth

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Genotypes:

FYPO:0000426 - normal endocytosis

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Genotypes:

FYPO:0002715 - normal Golgi apparatus morphology

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Genotypes:

FYPO:0001164 - normal growth on glucose carbon source

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Genotypes:

FYPO:0001402 - normal protein localization to cell cortex during vegetative growth

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Genotypes:

FYPO:0002332 - normal protein localization to Golgi apparatus

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Genotypes:

FYPO:0002717 - normal vacuole fusion during cellular hypotonic response

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Genotypes:

FYPO:0002714 - protein mislocalized to Golgi apparatus

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Genotypes:

FYPO:0000067 - resistance to brefeldin A

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Genotypes:

FYPO:0001450 - resistance to cold

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Genotypes:

FYPO:0001379 - resistance to tacrolimus

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Genotypes:

FYPO:0001501 - sensitive to brefeldin A

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Genotypes:

FYPO:0000086 - sensitive to tacrolimus

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Genotypes:

FYPO:0000115 - sensitive to valproic acid

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Genotypes:

FYPO:0001496 - viable elongated multiseptate vegetative cell

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Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF01369Sec7Sec7_domPfam
PF12783Sec7-like_HUSMon2/Sec7/BIG1-like_HUSPfam
PF23325TPR_28GBF1-like_TPRPfam
cd00171Sec7Sec7_domCDD
PS50190SEC7Sec7_domPROSITE profiles
SM00222Sec7Sec7_domSMART
G3DSA:1.10.1000.11:FF:000002CATH-FunFam
G3DSA:1.10.1000.11Sec7_C_sfCATH-Gene3D
G3DSA:1.10.220.20CATH-Gene3D
SSF48371ARM-type_foldSUPERFAMILY
SSF48425Sec7_dom_sfSUPERFAMILY
PTHR10663PANTHER

Orthologs

References / Literature

PMID:18257517 - Phosphoproteome analysis of fission yeast.
Wilson-Grady JT et al. J Proteome Res 2008 Mar;7(3):1088-97
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:26167880 - SR protein kinases promote splicing of nonconsensus introns.
Lipp JJ et al. Nat Struct Mol Biol 2015 Aug;22(8):611-7
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:29996109 - Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe.
Swaffer MP et al. Cell Rep 2018 Jul 10;24(2):503-514
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.
Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.
Halova L et al. Open Biol 2021 Apr;11(4):200405
PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.
Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963
PMID:34296454 - The TOR-dependent phosphoproteome and regulation of cellular protein synthesis.
Mak T et al. EMBO J 2021 Aug 16;40(16):e107911
PMID:39476757 - Characterization of Ksg1 protein kinase-dependent phosphoproteome in the fission yeast S. pombe.
Cipak L et al. Biochem Biophys Res Commun 2024 Oct 25;736:150895
PMID:23457617 - Haploinsufficiency of the Sec7 guanine nucleotide exchange factor gea1 impairs septation in fission yeast.
Eckler AM et al. PLoS One 2013;8(2):e56807
GO_REF:0000044 - Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt.
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.
Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:21712547 - Mitotic substrates of the kinase aurora with roles in chromatin regulation identified through quantitative phosphoproteomics of fission yeast.
Koch A et al. Sci Signal 2011 Jun 28;4(179):rs6
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:22146723 - Systematic localization study on novel proteins encoded by meiotically up-regulated ORFs in fission yeast.
Ikebe C et al. Biosci Biotechnol Biochem 2011;75(12):2364-70