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protein coding gene - tor2 (SPBC216.07c) - TORC1 serine/threonine protein kinase Tor2

Gene summary

Standard name
tor2
Systematic ID
SPBC216.07c
Product
TORC1 serine/threonine protein kinase Tor2
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
SPBC646.01c
UniProt ID
Q9Y7K2
ORFeome ID
34/34C09
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome II: 915085..922352 reverse strand

Annotation

PBO:0002663 - 2.7.1.137

Disease association

MONDO:0011818 - isolated focal cortical dysplasia type II

References:

MONDO:0014716 - macrocephaly-intellectual disability-neurodevelopmental disorder-small thorax syndrome

References:

MONDO:0100283 - overgrowth syndrome and/or cerebral malformations due to abnormalities in MTOR pathway genes

References:

GO biological process

GO:0110045 - negative regulation of cell cycle switching, mitotic to meiotic cell cycle

References:

GO:0031138 - negative regulation of conjugation with cellular fusion

References:

GO:0010972 - negative regulation of G2/M transition of mitotic cell cycle

References:

GO:0016242 - negative regulation of macroautophagy

References:

GO:0061188 - negative regulation of rDNA heterochromatin formation

References:

GO:0030307 - positive regulation of cell growth

References:

GO:2000767 - positive regulation of cytoplasmic translation

References:

GO:1900087 - positive regulation of G1/S transition of mitotic cell cycle

References:

GO:0120272 - positive regulation of nuclear mRNA surveillance of meiosis-specific transcripts

References:

GO:0032436 - positive regulation of proteasomal ubiquitin-dependent protein catabolic process

References:

GO:0060963 - positive regulation of ribosomal protein gene transcription by RNA polymerase II

References:

GO:0038202 - TORC1 signaling

References:

GO cellular component

GO:0000785 - chromatin

References:

GO:0005737 - cytoplasm

References:

GO:0005829 - cytosol

References:

GO:0030874 - nucleolar chromatin

References:

GO:0005634 - nucleus

References:

GO:0048471 - perinuclear region of cytoplasm

References:

GO:0034064 - Tor2-Mei2-Ste11 complex

References:

GO:0031931 - TORC1 complex

References:

GO:0005774 - vacuolar membrane

References:

GO molecular function

GO:0005515 - protein binding

References:

GO:0004672 - protein kinase activity

References:

GO:0004674 - protein serine/threonine kinase activity

References:

GO:0042134 - rRNA primary transcript binding

References:

Modification

MOD:00595 - monomannosylated residue

References:

MOD:00046 - O-phospho-L-serine

References:

MOD:00047 - O-phospho-L-threonine

References:

MOD:00048 - O4'-phospho-L-tyrosine

References:

MOD:00696 - phosphorylated residue

References:

Multi-locus phenotype

FYPO:0000400 - abnormal cell cycle arrest at mitotic G2/M phase transition

References:

Genotypes:

FYPO:0000444 - abnormal mitotic cell cycle arrest with replicated DNA

References:

Genotypes:

FYPO:0001430 - abnormal mitotic cell cycle arrest with unreplicated DNA

References:

Genotypes:

FYPO:0002678 - abolished protein phosphorylation

References:

Genotypes:

FYPO:0002033 - abolished protein phosphorylation during vegetative growth

References:

Genotypes:

FYPO:0000229 - cut

References:

Genotypes:

FYPO:0001592 - decreased arginine import

References:

Genotypes:

FYPO:0000082 - decreased cell population growth at high temperature

References:

Genotypes:

FYPO:0001407 - decreased cell population growth on glucose carbon source

References:

Genotypes:

FYPO:0007212 - decreased chromatin silencing at heterochromatin island

References:

Genotypes:

FYPO:0000708 - decreased mating efficiency

References:

Genotypes:

FYPO:0006470 - decreased mature rRNA level

References:

Genotypes:

FYPO:0003257 - decreased proline import

References:

Genotypes:

FYPO:0001324 - decreased protein level during vegetative growth

References:

Genotypes:

FYPO:0002391 - decreased protein localization to chromatin at rDNA

References:

Genotypes:

FYPO:0010038 - decreased protein localization to Golgi apparatus, with protein mislocalized to plasma membrane

References:

Genotypes:

FYPO:0001838 - decreased protein phosphorylation during vegetative growth

References:

Genotypes:

FYPO:0002768 - decreased protein ubiquitination during vegetative growth

References:

Genotypes:

FYPO:0001117 - decreased RNA level during vegetative growth

References:

Genotypes:

FYPO:0004085 - decreased vegetative cell growth

References:

Genotypes:

FYPO:0001355 - decreased vegetative cell population growth

References:

Genotypes:

FYPO:0000761 - increased conjugation frequency

References:

Genotypes:

FYPO:0006345 - increased duration of protein phosphorylation during nitrogen starvation

References:

Genotypes:

FYPO:0006074 - increased histone H3-K9 dimethylation at rDNA during vegetative growth

References:

Genotypes:

FYPO:0001043 - increased mating efficiency

References:

Genotypes:

FYPO:0003258 - increased proline import

References:

Genotypes:

FYPO:0001219 - increased protein level during cellular response to nitrogen starvation

References:

Genotypes:

FYPO:0002082 - increased protein ubiquitination during vegetative growth

References:

Genotypes:

FYPO:0001571 - increased protein-protein interaction

References:

Genotypes:

FYPO:0001890 - increased RNA level

References:

Genotypes:

FYPO:0002020 - increased RNA level during nitrogen starvation

References:

Genotypes:

FYPO:0000825 - increased RNA level during vegetative growth

References:

Genotypes:

FYPO:0002151 - inviable spore

References:

Genotypes:

FYPO:0001489 - inviable vegetative cell

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

FYPO:0000245 - loss of viability in stationary phase

References:

Genotypes:

FYPO:0000047 - normal cell population growth

References:

Genotypes:

FYPO:0007226 - normal chromatin silencing at heterochromatin island

References:

Genotypes:

FYPO:0005993 - normal cytoplasmic translation

References:

Genotypes:

FYPO:0000960 - normal growth on ethanol

References:

Genotypes:

FYPO:0001164 - normal growth on glucose carbon source

References:

Genotypes:

FYPO:0002672 - normal growth on rapamycin

References:

Genotypes:

FYPO:0007281 - normal level of meiotic gene mRNA during vegetative growth

References:

Genotypes:

FYPO:0001147 - normal mating efficiency

References:

Genotypes:

FYPO:0001134 - normal mature 18S rRNA level

References:

Genotypes:

FYPO:0000411 - normal mitotic cell cycle

References:

Genotypes:

FYPO:0003259 - normal proline import

References:

Genotypes:

FYPO:0003075 - normal protein kinase activity

References:

Genotypes:

FYPO:0000833 - normal protein level during vegetative growth

References:

Genotypes:

FYPO:0000776 - normal protein phosphorylation during vegetative growth

References:

Genotypes:

FYPO:0001357 - normal vegetative cell population growth

References:

Genotypes:

FYPO:0000099 - sensitive to canavanine

References:

Genotypes:

FYPO:0005203 - sensitive to ethionine

References:

Genotypes:

FYPO:0001525 - sensitive to L-thialysine

References:

Genotypes:

FYPO:0000111 - sensitive to rapamycin

References:

Genotypes:

FYPO:0000271 - sensitive to salt stress

References:

Genotypes:

FYPO:0000280 - sterile

References:

Genotypes:

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

Qualitative gene expression

PomGeneEx:0000018 - protein level increased

References:

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0005097 - abnormal cell cycle arrest in mitotic G1 phase

References:

Genotypes:

FYPO:0001430 - abnormal mitotic cell cycle arrest with unreplicated DNA

References:

Genotypes:

FYPO:0004481 - abolished cell population growth at high temperature

References:

Genotypes:

FYPO:0002678 - abolished protein phosphorylation

References:

Genotypes:

FYPO:0001592 - decreased arginine import

References:

Genotypes:

FYPO:0000082 - decreased cell population growth at high temperature

References:

Genotypes:

FYPO:0001407 - decreased cell population growth on glucose carbon source

References:

Genotypes:

FYPO:0007317 - decreased cytoplasmic translation

References:

Genotypes:

FYPO:0007213 - decreased histone H3-K9 dimethylation at heterochromatin island during vegetative growth

References:

Genotypes:

FYPO:0003230 - decreased histone H3-K9 methylation at heterochromatin island during vegetative growth

References:

Genotypes:

FYPO:0004461 - decreased level of regulation of sexual differentiation gene mRNA during nitrogen starvation

References:

Genotypes:

FYPO:0000708 - decreased mating efficiency

References:

Genotypes:

FYPO:0003694 - decreased mature 18S rRNA level

References:

Genotypes:

FYPO:0006470 - decreased mature rRNA level

References:

Genotypes:

FYPO:0002583 - decreased mature tRNA level during vegetative growth

References:

Genotypes:

FYPO:0006748 - decreased pre-tRNA level during vegetative growth

References:

Genotypes:

FYPO:0003257 - decreased proline import

References:

Genotypes:

FYPO:0000846 - decreased protein degradation during vegetative growth

References:

Genotypes:

FYPO:0005746 - decreased protein export from nucleus during glucose starvation

References:

Genotypes:

FYPO:0001382 - decreased protein kinase activity

References:

Genotypes:

FYPO:0000835 - decreased protein level

References:

Genotypes:

FYPO:0001283 - decreased protein level during cellular response to nitrogen starvation

References:

Genotypes:

FYPO:0001324 - decreased protein level during vegetative growth

References:

Genotypes:

FYPO:0002391 - decreased protein localization to chromatin at rDNA

References:

Genotypes:

FYPO:0004455 - decreased protein localization to nucleus

References:

Genotypes:

FYPO:0002679 - decreased protein phosphorylation

References:

Genotypes:

FYPO:0008411 - decreased protein phosphorylation during mating

References:

Genotypes:

FYPO:0001838 - decreased protein phosphorylation during vegetative growth

References:

Genotypes:

FYPO:0001645 - decreased protein-protein interaction

References:

Genotypes:

FYPO:0003827 - decreased ribosomal S6 protein phosphorylation during vegetative growth

References:

Genotypes:

FYPO:0001152 - decreased RNA level during nitrogen starvation

References:

Genotypes:

FYPO:0001117 - decreased RNA level during vegetative growth

References:

Genotypes:

FYPO:0000581 - decreased spore germination frequency

References:

Genotypes:

FYPO:0001355 - decreased vegetative cell population growth

References:

Genotypes:

FYPO:0000712 - delayed onset of cell cycle arrest in mitotic G1 phase in response to nitrogen starvation

References:

Genotypes:

FYPO:0006345 - increased duration of protein phosphorylation during nitrogen starvation

References:

Genotypes:

FYPO:0006548 - increased gene expression

References:

Genotypes:

FYPO:0006074 - increased histone H3-K9 dimethylation at rDNA during vegetative growth

References:

Genotypes:

FYPO:0002173 - increased level of meiotic gene mRNA during vegetative growth

References:

Genotypes:

FYPO:0002172 - increased level of nitrogen starvation gene mRNA during vegetative growth

References:

Genotypes:

FYPO:0007788 - increased macroautophagy during vegetative growth

References:

Genotypes:

FYPO:0001043 - increased mating efficiency

References:

Genotypes:

FYPO:0000501 - increased mitophagy

References:

Genotypes:

FYPO:0001974 - increased number of cells with 1C DNA content

References:

Genotypes:

FYPO:0002700 - increased protein kinase activity

References:

Genotypes:

FYPO:0003152 - increased protein level during cellular response to heat

References:

Genotypes:

FYPO:0001327 - increased protein level during vegetative growth

References:

Genotypes:

FYPO:0004032 - increased protein localization to chromatin at rDNA

References:

Genotypes:

FYPO:0001130 - increased protein localization to nucleus during vegetative growth

References:

Genotypes:

FYPO:0004333 - increased protein phosphorylation during cellular response to hydrogen peroxide

References:

Genotypes:

FYPO:0004949 - increased protein phosphorylation during cellular response to rapamycin

References:

Genotypes:

FYPO:0005197 - increased protein phosphorylation during glucose starvation

References:

Genotypes:

FYPO:0002681 - increased protein phosphorylation during nitrogen starvation

References:

Genotypes:

FYPO:0001038 - increased protein phosphorylation during vegetative growth

References:

Genotypes:

FYPO:0002082 - increased protein ubiquitination during vegetative growth

References:

Genotypes:

FYPO:0001890 - increased RNA level

References:

Genotypes:

FYPO:0006542 - increased RNA level during mitosis

References:

Genotypes:

FYPO:0000825 - increased RNA level during vegetative growth

References:

Genotypes:

FYPO:0000780 - increased transcription during vegetative growth

References:

Genotypes:

FYPO:0001309 - increased viability in stationary phase

References:

Genotypes:

FYPO:0002430 - inviable after spore germination, multiple cell divisions

References:

Genotypes:

FYPO:0001991 - inviable after spore germination, without cell division

References:

Genotypes:

FYPO:0000951 - inviable small vegetative cell

References:

Genotypes:

FYPO:0002482 - inviable spheroid vegetative cell

References:

Genotypes:

FYPO:0002151 - inviable spore

References:

Genotypes:

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

FYPO:0003031 - mating without nitrogen starvation

References:

Genotypes:

FYPO:0001000 - normal cell cycle arrest in mitotic G1 phase during nitrogen starvation

References:

Genotypes:

FYPO:0001164 - normal growth on glucose carbon source

References:

Genotypes:

FYPO:0002672 - normal growth on rapamycin

References:

Genotypes:

FYPO:0002673 - normal growth on torin1

References:

Genotypes:

FYPO:0008380 - normal histone H2A phosphorylation during cellular response to camptothecin

References:

Genotypes:

FYPO:0010029 - normal histone H3-K9 dimethylation at rDNA during vegetative growth

References:

Genotypes:

FYPO:0003235 - normal histone H3-K9 methylation at centromere outer repeat during vegetative growth

References:

Genotypes:

FYPO:0005280 - normal level of glucose-repressed gene mRNA during vegetative growth

References:

Genotypes:

FYPO:0006750 - normal pre-tRNA level during nitrogen starvation

References:

Genotypes:

FYPO:0000833 - normal protein level during vegetative growth

References:

Genotypes:

FYPO:0002332 - normal protein localization to Golgi apparatus

References:

Genotypes:

FYPO:0007705 - normal protein localization to lateral cell cortex during glucose starvation

References:

Genotypes:

FYPO:0002674 - normal protein localization to plasma membrane

References:

Genotypes:

FYPO:0004422 - normal protein phosphorylation

References:

Genotypes:

FYPO:0001266 - normal protein phosphorylation during cellular response to salt stress

References:

Genotypes:

FYPO:0000776 - normal protein phosphorylation during vegetative growth

References:

Genotypes:

FYPO:0006249 - normal tRNA aminoacylation

References:

Genotypes:

FYPO:0002085 - normal vegetative cell growth

References:

Genotypes:

FYPO:0001357 - normal vegetative cell population growth

References:

Genotypes:

FYPO:0001420 - normal vegetative cell population growth rate

References:

Genotypes:

FYPO:0001029 - resistance to canavanine

References:

Genotypes:

FYPO:0001524 - resistance to L-thialysine

References:

Genotypes:

FYPO:0004513 - resistance to latrunculin A

References:

Genotypes:

FYPO:0005193 - resistance to torin1

References:

Genotypes:

FYPO:0001501 - sensitive to brefeldin A

References:

Genotypes:

FYPO:0004375 - sensitive to Ku-0063794

References:

Genotypes:

FYPO:0003116 - sensitive to plumbagin

References:

Genotypes:

FYPO:0000111 - sensitive to rapamycin

References:

Genotypes:

FYPO:0002701 - sensitive to torin1

References:

Genotypes:

FYPO:0003859 - sensitive to wortmannin

References:

Genotypes:

FYPO:0000280 - sterile

References:

Genotypes:

FYPO:0000648 - viable small vegetative cell

References:

Genotypes:

FYPO:0006822 - viable small vegetative cell with normal cell growth rate

References:

Genotypes:

FYPO:0001877 - viable thin vegetative cell

References:

Genotypes:

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF02260FATCFATC_domPFAM
PF00454PI3_PI4_kinasePI3/4_kinase_cat_domPFAM
PF11865mTOR_dommTOR_domPFAM
PF23593HEAT_ATRHEAT_ATRPFAM
PF02259FATPIK-rel_kinase_FATPFAM
PF13513HEAT_EZPFAM
PF08771FRB_domFRB_domPFAM
cd05169PIKKc_TORTOR_catCDD
PS00916PI3_4_KINASE_2PI3/4_kinase_CSPROSITE_PATTERNS
PS00915PI3_4_KINASE_1PI3/4_kinase_CSPROSITE_PATTERNS
PS51189FATPIK_FATPROSITE_PROFILES
PS51190FATCFATC_domPROSITE_PROFILES
PS50290PI3_4_KINASE_3PI3/4_kinase_cat_domPROSITE_PROFILES
PS50077HEAT_REPEATHEAT_type_2PROSITE_PROFILES
SM01346DUF3385_3mTOR_domSMART
SM01343FATC_2FATC_domSMART
SM00146pi3k_hr1_6PI3/4_kinase_cat_domSMART
SM01345Rapamycin_bind_3SMART
G3DSA:1.25.10.10:FF:000371FUNFAM
G3DSA:1.10.1070.11:FF:000040FUNFAM
G3DSA:1.20.120.150:FF:000001FUNFAM
G3DSA:3.30.1010.10:FF:000004FUNFAM
SSF48371ARM repeatARM-type_foldSUPERFAMILY
SSF47212FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)FRB_sfSUPERFAMILY
SSF56112Protein kinase-like (PK-like)Kinase-like_dom_sfSUPERFAMILY
G3DSA:1.10.1070.11PI3/4_kinase_cat_sfGENE3D
G3DSA:1.25.10.10ARM-likeGENE3D
G3DSA:1.25.40.10Tetratricopeptide repeat domainTPR-like_helical_dom_sfGENE3D
G3DSA:1.20.120.150FRB_sfGENE3D
PTHR11139ATAXIA TELANGIECTASIA MUTATED ATM -RELATEDDDR_Repair_KinasePANTHER
CoilCoilCOILS

Orthologs

References / Literature

PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.
Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:22344254 - The Vam6 and Gtr1-Gtr2 pathway activates TORC1 in response to amino acids in fission yeast.
Valbuena N et al. J Cell Sci 2012 Apr 15;125(Pt 8):1920-8
PMID:26776736 - Nutritional Control of Cell Size by the Greatwall-Endosulfine-PP2A·B55 Pathway.
Chica N et al. Curr Biol 2016 Feb 08;26(3):319-30
PMID:25814783 - Conservation of the Tsc/Rheb/TORC1/S6K/S6 Signaling in Fission Yeast.
Nakashima A et al. Enzymes 2010;28:167-187
PMID:39910760 - Novel TORC1 inhibitor Ecl1 is regulated by phosphorylation in fission yeast.
Ohtsuka H et al. Aging Cell 2025 Feb 05;:e14450
PMID:17046992 - Fission yeast Tor2 promotes cell growth and represses cell differentiation.
Alvarez B et al. J Cell Sci 2006 Nov 01;119(Pt 21):4475-85
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:19620394 - Distinctive responses to nitrogen starvation in the dominant active mutants of the fission yeast Rheb GTPase.
Murai T et al. Genetics 2009 Oct;183(2):517-27
PMID:29079657 - TORC1 and TORC2 converge to regulate the SAGA co-activator in response to nutrient availability.
Laboucarié T et al. EMBO Rep 2017 Dec;18(12):2197-2218
PMID:23934889 - TORC1 signaling is governed by two negative regulators in fission yeast.
Ma N et al. Genetics 2013 Oct;195(2):457-68
PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.
Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87
PMID:29199950 - Ragulator and GATOR1 complexes promote fission yeast growth by attenuating TOR complex 1 through Rag GTPases.
Chia KH et al. Elife 2017 Dec 04;6
PMID:31474649 - Identification of 15 New Bypassable Essential Genes of Fission Yeast.
Takeda A et al. Cell Struct Funct 2019 Sep 27;44(2):113-119
PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.
Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963
PMID:35639710 - Characterization of canavanine-resistance of cat1 and vhc1 deletions and a dominant any1 mutation in fission yeast.
Ait Saada A et al. PLoS One 2022;17(5):e0269276
PMID:38780300 - Nitrogen availability is important for preventing catastrophic mitosis in fission yeast.
Zemlianski V et al. J Cell Sci 2024 May 23;
PMID:27227887 - The Loss of Lam2 and Npr2-Npr3 Diminishes the Vacuolar Localization of Gtr1-Gtr2 and Disinhibits TORC1 Activity in Fission Yeast.
Ma N et al. PLoS One 2016;11(5):e0156239
PMID:41227381 - The BUD31 Homologous Gene in Schizosaccharomyces pombe Is Evolutionarily Conserved and Can Be Linked to Cellular Processes Regulated by the TOR Pathway.
Vig I et al. Cells 2025 Nov 05;14(21)
PMID:24741065 - S. pombe TORC1 activates the ubiquitin-proteasomal degradation of the meiotic regulator Mei2 in cooperation with Pat1 kinase.
Otsubo Y et al. J Cell Sci 2014 Jun 15;127(Pt 12):2639-46
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:21625337 - Rab small GTPase emerges as a regulator of TOR complex 2.
Tatebe H et al. Small GTPases 2010 Nov;1(3):180-182
PMID:20144990 - Fission yeast TORC1 regulates phosphorylation of ribosomal S6 proteins in response to nutrients and its activity is inhibited by rapamycin.
Nakashima A et al. J Cell Sci 2010 Mar 01;123(Pt 5):777-86
PMID:26644575 - Discovery of a nucleocytoplasmic O-mannose glycoproteome in yeast.
Halim A et al. Proc Natl Acad Sci U S A 2015 Dec 22;112(51):15648-53
PMID:28041796 - A PP2A-B55-Mediated Crosstalk between TORC1 and TORC2 Regulates the Differentiation Response in Fission Yeast.
Martín R et al. Curr Biol 2017 Jan 23;27(2):175-188
PMID:37913773 - TOR inactivation triggers heterochromatin formation in rDNA during glucose starvation.
Hirai H et al. Cell Rep 2023 Nov 28;42(11):113320
PMID:23163955 - Analysis of stress-induced duplex destabilization (SIDD) properties of replication origins, genes and intergenes in the fission yeast, Schizosaccharomyces pombe.
Yadav MP et al. BMC Res Notes 2012 Nov 19;5:643
PMID:33574613 - TOR targets an RNA processing network to regulate facultative heterochromatin, developmental gene expression and cell proliferation.
Wei Y et al. Nat Cell Biol 2021 Mar;23(3):243-256
PMID:22976295 - Psk1, an AGC kinase family member in fission yeast, is directly phosphorylated and controlled by TORC1 and functions as S6 kinase.
Nakashima A et al. J Cell Sci 2012 Dec 01;125(Pt 23):5840-9
PMID:19417002 - Fission yeast Tor1 functions as part of TORC1 to control mitotic entry through the stress MAPK pathway following nutrient stress.
Hartmuth S et al. J Cell Sci 2009 Jun 01;122(Pt 11):1737-46
PMID:27191590 - Fission Yeast SCYL1/2 Homologue Ppk32: A Novel Regulator of TOR Signalling That Governs Survival during Brefeldin A Induced Stress to Protein Trafficking.
Kowalczyk KM et al. PLoS Genet 2016 May;12(5):e1006041
PMID:26689777 - Tor Signaling Regulates Transcription of Amino Acid Permeases through a GATA Transcription Factor Gaf1 in Fission Yeast.
Ma Y et al. PLoS One 2015;10(12):e0144677
PMID:31641022 - The cytosolic form of aspartate aminotransferase is required for full activation of TOR complex 1 in fission yeast.
Reidman S et al. J Biol Chem 2019 Nov 29;294(48):18244-18255
PMID:40132111 - A fission yeast CENP-B homologue Abp1 prevents RNAi-mediated heterochromatin formation at ribosomal DNA repeats.
Tsunemine S et al. Genetics 2025 Mar 25;
PMID:31456006 - Leucine depletion extends the lifespans of leucine-auxotrophic fission yeast by inducing Ecl1 family genes via the transcription factor Fil1.
Ohtsuka H et al. Mol Genet Genomics 2019 Dec;294(6):1499-1509
PMID:27876895 - Multiple crosstalk between TOR and the cell integrity MAPK signaling pathway in fission yeast.
Madrid M et al. Sci Rep 2016 Nov 23;6:37515
PMID:17261596 - Loss of the TOR kinase Tor2 mimics nitrogen starvation and activates the sexual development pathway in fission yeast.
Matsuo T et al. Mol Cell Biol 2007 Apr;27(8):3154-64
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:26447710 - Constitutive Tor2 Activity Promotes Retention of the Amino Acid Transporter Agp3 at Trans-Golgi/Endosomes in Fission Yeast.
Liu Q et al. PLoS One 2015;10(10):e0139045
PMID:21340088 - Microarray-based target identification using drug hypersensitive fission yeast expressing ORFeome.
Arita Y et al. Mol Biosyst 2011 May;7(5):1463-72
PMID:29996109 - Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe.
Swaffer MP et al. Cell Rep 2018 Jul 10;24(2):503-514
PMID:22645648 - The reverse, but coordinated, roles of Tor2 (TORC1) and Tor1 (TORC2) kinases for growth, cell cycle and separase-mediated mitosis in Schizosaccharomyces pombe.
Ikai N et al. Open Biol 2011 Nov;1(3):110007
PMID:30321377 - Proteomic profiling and functional characterization of post-translational modifications of the fission yeast RNA exosome.
Telekawa C et al. Nucleic Acids Res 2018 Nov 30;46(21):11169-11183
PMID:30301783 - The RHEB-mTOR axis regulates expression of Tf2 transposons in fission yeast.
Nakase Y et al. J Cell Sci 2018 Nov 21;131(22)
PMID:39010328 - Fission yeast Pib2 localizes to vacuolar membranes and regulates TOR complex 1 through evolutionarily conserved domains.
Morozumi Y et al. FEBS Lett 2024 Jul 15;
PMID:41258116 - TORC2 inactivation promotes heterochromatin formation in rDNA and prolongs viability of quiescent fission yeast cells.
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