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protein coding gene - dpm2 (SPBC21B10.11) - dolichol-phosphate mannosyltransferase regulatory subunit Dpm2

Gene summary

Standard name
dpm2
Systematic ID
SPBC21B10.11
Product
dolichol-phosphate mannosyltransferase regulatory subunit Dpm2
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
Q9USW6
ORFeome ID
01/01B12
Characterisation status
biological role inferred
Feature type
mRNA gene
Genomic location
chromosome II: 1650289..1650680 reverse strand

Annotation

Disease association

MONDO:0015286 - congenital disorder of glycosylation

References:

MONDO:0014023 - congenital muscular dystrophy with intellectual disability and severe epilepsy

References:

MONDO:0005066 - metabolic disease

References:

GO biological process

GO:0180047 - dolichol phosphate mannose biosynthetic process

References:

GO:0006506 - GPI anchor biosynthetic process

References:

GO cellular component

GO:0005737 - cytoplasm

References:

GO:0033185 - dolichol-phosphate-mannose synthase complex

References:

GO:0005783 - endoplasmic reticulum

References:

GO:0005789 - endoplasmic reticulum membrane

References:

GO molecular function

GO:0008047 - enzyme activator activity

References:

Protein sequence feature

SO:0000418 - signal_peptide

SO:0001812 - transmembrane_helix

References:

Qualitative gene expression

PomGeneEx:0000011 - RNA level increased

References:

Quantitative gene expression

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

FYPO:0001511 - inviable vegetative cell, abnormal cell shape, normal cell size

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF07297DPM2DPM2Pfam
PTHR15039DPM2PANTHER
Transmembrane alpha helixDeepTMHMM

Orthologs

References / Literature

GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:27984744 - Survival in Quiescence Requires the Euchromatic Deployment of Clr4/SUV39H by Argonaute-Associated Small RNAs.
Joh RI et al. Mol Cell 2016 Dec 15;64(6):1088-1101
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:18387370 - Dolichol-phosphate mannose synthase: structure, function and regulation.
Maeda Y et al. Biochim Biophys Acta 2008 Jun;1780(6):861-8
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
GO_REF:0000002 - Comments
PMID:33109728 - High-Throughput Identification of Nuclear Envelope Protein Interactions in Schizosaccharomyces pombe Using an Arrayed Membrane Yeast-Two Hybrid Library.
Varberg JM et al. G3 (Bethesda) 2020 Dec 03;10(12):4649-4663
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
Pfam:PF07297 - Unknown title
PMID:10835346 - Human dolichol-phosphate-mannose synthase consists of three subunits, DPM1, DPM2 and DPM3.
Maeda Y et al. EMBO J 2000 Jun 01;19(11):2475-82
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:12161753 - The transcriptional program of meiosis and sporulation in fission yeast.
Mata J et al. Nat Genet 2002 Sep;32(1):143-7
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.
Skribbe M et al. Mol Cell 2025 Feb 19;
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:11152613 - Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes.
Krogh A et al. J Mol Biol 2001 Jan 19;305(3):567-80
PB_REF:0000003 - Disease Association Curation