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protein coding gene - rec6 (SPBC21B10.12) - meiotic recombination protein Rec6

Gene summary

Standard name
rec6
Systematic ID
SPBC21B10.12
Product
meiotic recombination protein Rec6
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
P40385
ORFeome ID
40/40A02
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome II: 1648948..1650156 reverse strand

Annotation

Comment

PBO:0001192 - promoter contains MCB

References:

Disease association

MONDO:0032747 - hydatidiform mole, recurrent, 4

References:

GO biological process

GO:0042138 - meiotic DNA double-strand break formation

References:

GO:0007131 - reciprocal meiotic recombination

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GO cellular component

GO:0005739 - mitochondrion

References:

GO:0005634 - nucleus

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Modification

MOD:00696 - phosphorylated residue

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Multi-locus phenotype

FYPO:0000581 - decreased spore germination frequency

References:

Genotypes:

Qualitative gene expression

PomGeneEx:0000019 - protein level decreased

References:

PomGeneEx:0000011 - RNA level increased

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Quantitative gene expression

PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0000151 - abnormal meiotic chromosome segregation

References:

Genotypes:

FYPO:0003181 - abolished meiotic DNA double-strand break formation

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Genotypes:

FYPO:0000484 - abolished meiotic recombination

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Genotypes:

FYPO:0009092 - decreased cell population growth on lysine and serine nitrogen source

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Genotypes:

FYPO:0003179 - decreased intragenic meiotic recombination

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Genotypes:

FYPO:0000708 - decreased mating efficiency

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Genotypes:

FYPO:0000581 - decreased spore germination frequency

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Genotypes:

FYPO:0001309 - increased viability in stationary phase

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Genotypes:

FYPO:0000969 - normal growth during cellular response to UV

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Genotypes:

FYPO:0000957 - normal growth on methyl methanesulfonate

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Genotypes:

FYPO:0004602 - normal linear element morphology

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Genotypes:

FYPO:0002052 - normal sporulation frequency

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Genotypes:

FYPO:0000764 - resistance to cycloheximide

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Genotypes:

FYPO:0001453 - resistance to ethanol

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Genotypes:

FYPO:0009043 - resistance to potassium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0003383 - resistance to tert-butyl hydroperoxide

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Genotypes:

FYPO:0000830 - resistance to vanadate

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Genotypes:

FYPO:0009086 - sensitive to lithium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0000089 - sensitive to methyl methanesulfonate

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Genotypes:

FYPO:0001234 - slow vegetative cell population growth

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Genotypes:

FYPO:0002060 - viable vegetative cell population

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Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

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Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

Warnings

PBO:0000070 - gene structure updated

References:

Protein features

IDNameInterPro nameDB name
mobidb-lite-Disorderdisorder_predictionMOBIDB-Disorder
mobidb-lite-Low-complexitydisorder_predictionMOBIDB-Low-complexity

Orthologs

References / Literature

PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.
Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704
PMID:28410370 - A systematic screen for morphological abnormalities during fission yeast sexual reproduction identifies a mechanism of actin aster formation for cell fusion.
Dudin O et al. PLoS Genet 2017 Apr;13(4):e1006721
PMID:10882124 - Meiotic DNA breaks associated with recombination in S. pombe.
Cervantes MD et al. Mol Cell 2000 May;5(5):883-8
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:25452419 - Parallel profiling of fission yeast deletion mutants for proliferation and for lifespan during long-term quiescence.
Sideri T et al. G3 (Bethesda) 2014 Dec 01;5(1):145-55
PMID:12161753 - The transcriptional program of meiosis and sporulation in fission yeast.
Mata J et al. Nat Genet 2002 Sep;32(1):143-7
PMID:25579976 - Phosphorylation of cohesin Rec11/SA3 by casein kinase 1 promotes homologous recombination by assembling the meiotic chromosome axis.
Sakuno T et al. Dev Cell 2015 Jan 26;32(2):220-30
PMID:22841486 - A central coupler for recombination initiation linking chromosome architecture to S phase checkpoint.
Miyoshi T et al. Mol Cell 2012 Sep 14;47(5):722-33
PMID:30388401 - Causative Mutations and Mechanism of Androgenetic Hydatidiform Moles.
Nguyen NMP et al. Am J Hum Genet 2018 Nov 01;103(5):740-751
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:2806887 - Meiotic recombination-deficient mutants of Schizosaccharomyces pombe.
Ponticelli AS et al. Genetics 1989 Sep;123(1):45-54
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:9136000 - The Schizosaccharomyces pombe rec16 gene product regulates multiple meiotic events.
Li YF et al. Genetics 1997 May;146(1):57-67
PMID:18818364 - Conservation and rewiring of functional modules revealed by an epistasis map in fission yeast.
Roguev A et al. Science 2008 Oct 17;322(5900):405-10
PMID:15238514 - Conserved and nonconserved proteins for meiotic DNA breakage and repair in yeasts.
Young JA et al. Genetics 2004 Jun;167(2):593-605
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:29259000 - Genes Important for Schizosaccharomyces pombe Meiosis Identified Through a Functional Genomics Screen.
Blyth J et al. Genetics 2018 Feb;208(2):589-603
PMID:8299939 - Region-specific activators of meiotic recombination in Schizosaccharomyces pombe.
DeVeaux LC et al. Genes Dev 1994 Jan;8(2):203-10
PMID:35820914 - Antagonistic effects of mitochondrial matrix and intermembrane space proteases on yeast aging.
Vega M et al. BMC Biol 2022 Jul 12;20(1):160
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:26917764 - The TopoVIB-Like protein family is required for meiotic DNA double-strand break formation.
Robert T et al. Science 2016 Feb 26;351(6276):943-9
PMID:8005432 - Transient, meiosis-induced expression of the rec6 and rec12 genes of Schizosaccharomyces pombe.
Lin Y et al. Genetics 1994 Mar;136(3):769-79
PMID:12529438 - Global transcriptional responses of fission yeast to environmental stress.
Chen D et al. Mol Biol Cell 2003 Jan;14(1):214-29
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:9671035 - Global control of meiotic recombination genes by Schizosaccharomyces pombe rec16 (rep1).
Ding R et al. Mol Gen Genet 1998 Jun;258(6):663-70
PMID:12665553 - Linear element formation and their role in meiotic sister chromatid cohesion and chromosome pairing.
Molnar M et al. J Cell Sci 2003 May 01;116(Pt 9):1719-31
PMID:11719193 - Mus81-Eme1 are essential components of a Holliday junction resolvase.
Boddy MN et al. Cell 2001 Nov 16;107(4):537-48
GO_REF:0000051 - S. pombe keyword mapping
PMID:27984744 - Survival in Quiescence Requires the Euchromatic Deployment of Clr4/SUV39H by Argonaute-Associated Small RNAs.
Joh RI et al. Mol Cell 2016 Dec 15;64(6):1088-1101
PMID:14648198 - DSC1-MCB regulation of meiotic transcription in Schizosaccharomyces pombe.
Cunliffe L et al. Mol Genet Genomics 2004 Feb;271(1):60-71