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protein coding gene - kgd4 (SPBC21B10.14) - mitochondrial alpha-ketoglutarate dehydrogenase adaptor subunit Ymr31/Kgd4

Gene summary

Standard name
kgd4
Systematic ID
SPBC21B10.14
Product
mitochondrial alpha-ketoglutarate dehydrogenase adaptor subunit Ymr31/Kgd4
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
ymr31, prl41, SPNCRNA.41
UniProt ID
G2TRP3
Characterisation status
biological role inferred
Feature type
mRNA gene
Genomic location
chromosome II: 1652031..1652538 forward strand

Annotation

GO biological process

GO:0006099 - tricarboxylic acid cycle

References:

GO cellular component

GO:0005743 - mitochondrial inner membrane

References:

GO:0045252 - oxoglutarate dehydrogenase complex

References:

GO molecular function

GO:0030674 - protein-macromolecule adaptor activity

References:

Protein sequence feature

SO:0001808 - mitochondrial_targeting_signal

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Qualitative gene expression

PomGeneEx:0000018 - protein level increased

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Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0003743 - decreased cell population growth during glucose starvation

References:

Genotypes:

FYPO:0000251 - decreased cell population growth on galactose carbon source

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Genotypes:

FYPO:0009091 - decreased cell population growth on lysine and proline nitrogen source

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Genotypes:

FYPO:0009099 - decreased cell population growth on mannitol carbon source

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Genotypes:

FYPO:0002693 - resistance to diamide

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Genotypes:

FYPO:0009038 - resistance to egtazic acid

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Genotypes:

FYPO:0009085 - resistance to lithium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0009087 - resistance to magnesium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0001501 - sensitive to brefeldin A

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Genotypes:

FYPO:0000087 - sensitive to hydrogen peroxide

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Genotypes:

FYPO:0000088 - sensitive to hydroxyurea

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Genotypes:

FYPO:0001719 - sensitive to lithium

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Genotypes:

FYPO:0003656 - sensitive to vanadate

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Warnings

PBO:0000082 - new gene

References:

PBO:0000406 - previously annotated as ncRNA

PBO:0091733 - previously thought to be a ribosomal protein

Protein features

IDNameInterPro nameDB name
PF10937Kgd4-YMR31Kgd4/YMR-31PFAM

Orthologs

References / Literature

PMID:12597277 - Abundant poly(A)-bearing RNAs that lack open reading frames in Schizosaccharomyces pombe.
Watanabe T et al. DNA Res 2002 Dec 31;9(6):209-15
PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.
Skribbe M et al. Mol Cell 2025 Feb 19;
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:31626996 - Multiplexed proteome profiling of carbon source perturbations in two yeast species with SL-SP3-TMT.
Paulo JA et al. J Proteomics 2020 Jan 06;210:103531
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:36408920 - UniProt: the Universal Protein Knowledgebase in 2023.
UniProt Consortium Nucleic Acids Res 2023 Jan 06;51(D1):D523-D531
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6