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protein coding gene - trm140 (SPBC21C3.07c) - tRNA (cytosine-3) methyltransferase Trm140

Gene summary

Standard name
trm140
Systematic ID
SPBC21C3.07c
Product
tRNA (cytosine-3) methyltransferase Trm140
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
Q9P7L6
ORFeome ID
16/16H01
Characterisation status
biological role inferred
Feature type
mRNA gene
Genomic location
chromosome II: 3807091..3808853 reverse strand

Annotation

GO biological process

GO:0106217 - tRNA C3-cytosine methylation

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GO molecular function

GO:0052735 - tRNA (cytidine-N3)-methyltransferase activity

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Qualitative gene expression

PomGeneEx:0000019 - protein level decreased

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Quantitative gene expression

PBO:0006310 - protein level

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PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0000059 - abnormal mitotic cell cycle

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Genotypes:

FYPO:0009053 - decreased cell population growth on glutamate nitrogen source

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Genotypes:

FYPO:0009091 - decreased cell population growth on lysine and proline nitrogen source

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Genotypes:

FYPO:0009092 - decreased cell population growth on lysine and serine nitrogen source

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Genotypes:

FYPO:0009073 - decreased cell population growth on lysine nitrogen source

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Genotypes:

FYPO:0000250 - decreased cell population growth on proline nitrogen source

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FYPO:0007562 - decreased cell population growth on serine nitrogen source

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Genotypes:

FYPO:0001176 - decreased cell population growth on sucrose carbon source

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Genotypes:

FYPO:0000470 - decreased mating type switching

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Genotypes:

FYPO:0000245 - loss of viability in stationary phase

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FYPO:0000067 - resistance to brefeldin A

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FYPO:0001450 - resistance to cold

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FYPO:0009038 - resistance to egtazic acid

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FYPO:0001103 - resistance to hydrogen peroxide

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FYPO:0009085 - resistance to lithium chloride and sodium dodecyl sulfate

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FYPO:0009087 - resistance to magnesium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0007933 - sensitive to 2,2′-dipyridyl

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Genotypes:

FYPO:0001097 - sensitive to amitrole

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FYPO:0009067 - sensitive to amorolfine

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FYPO:0000097 - sensitive to caffeine during vegetative growth

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FYPO:0009069 - sensitive to ciclopirox olamine

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FYPO:0000799 - sensitive to diamide

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FYPO:0007928 - sensitive to ethylenediaminetetraacetic acid

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FYPO:0007924 - sensitive to potassium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0002328 - sensitive to terbinafine

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FYPO:0000115 - sensitive to valproic acid

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FYPO:0003656 - sensitive to vanadate

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Genotypes:

FYPO:0002215 - viable curved elongated vegetative cell

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Genotypes:

FYPO:0002060 - viable vegetative cell population

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Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Warnings

PBO:0004671 - tandem fusion protein in S. cerevisiae, SPBC21C3.07c is related to the C-terminal region of YOR239W

Protein features

IDNameInterPro nameDB name
PF08242Methyltransf_12Methyltransf_12PFAM
cd02440AdoMet_MTasesCDD
G3DSA:3.40.50.150:FF:000298FUNFAM
SSF53335S-adenosyl-L-methionine-dependent methyltransferasesSAM-dependent_MTases_sfSUPERFAMILY
G3DSA:3.40.50.150Vaccinia Virus protein VP39SAM-dependent_MTases_sfGENE3D
PTHR22809METHYLTRANSFERASE-RELATEDMETTL2/6/8-likePANTHER
PIRSF037755Mettl2METTL2/6/8-likePIRSF

Orthologs

References / Literature

PMID:40015273 - A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin.
Skribbe M et al. Mol Cell 2025 Feb 19;
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:29852001 - New insights into donor directionality of mating-type switching in Schizosaccharomyces pombe.
Maki T et al. PLoS Genet 2018 May;14(5):e1007424
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:27354703 - Evolving specificity of tRNA 3-methyl-cytidine-32 (m3C32) modification: a subset of tRNAsSer requires N6-isopentenylation of A37.
Arimbasseri AG et al. RNA 2016 Sep;22(9):1400-10
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:28281664 - Genetic interactions and functional analyses of the fission yeast gsk3 and amk2 single and double mutants defective in TORC1-dependent processes.
Rallis C et al. Sci Rep 2017 Mar 10;7:44257
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12
PMID:34250083 - Barcode sequencing and a high-throughput assay for chronological lifespan uncover ageing-associated genes in fission yeast.
Romila CA et al. Microb Cell 2021 Jul 05;8(7):146-160
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105