protein coding gene - rib7 (SPBC21C3.10c) - 5-amino-6-(5-phosphoribosylamino) uracil reductase Rib7

Gene summary

Standard name: rib7
Systematic ID: SPBC21C3.10c
Product: 5-amino-6-(5-phosphoribosylamino) uracil reductase Rib7
Organism: Schizosaccharomyces pombe (fission yeast)
UniProt ID: Q9P7L3
ORFeome ID: 10/10C06
Characterisation status: biological role inferred
Feature type: mRNA gene
Genomic location: chromosome II: 3812415..3813268 reverse strand

Annotation

PBO:0004678 - 1.1.1.193

GO biological process

GO:0009231 - riboflavin biosynthetic process

References:

GO_REF:0000024

GO cellular component

GO:0005829 - cytosol

References:

PMID:16823372

GO:0005634 - nucleus

References:

PMID:16823372

GO molecular function

GO:0008703 - 5-amino-6-(5-phosphoribosylamino)uracil reductase activity

References:

GO_REF:0000024

Modification

MOD:01148 - ubiquitinylated lysine

References:

PMID:37970674

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

PMID:23101633

Single locus phenotype

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

rib7delta

FYPO:0001511 - inviable vegetative cell, abnormal cell shape, normal cell size

References:

PMID:23697806

Genotypes:

rib7delta

Taxonomic conservation

PBO:0011067 - conserved in bacteria

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

Protein features

ID	Name	InterPro name	DB name
PF01872	RibD_C	RibDG_C	PFAM
G3DSA:3.40.430.10:FF:000011			FUNFAM
SSF53597	Dihydrofolate reductase-like	DHFR-like_dom_sf	SUPERFAMILY
G3DSA:3.40.430.10	Dihydrofolate Reductase, subunit A	DHFR-like_dom_sf	GENE3D
PTHR38011	DIHYDROFOLATE REDUCTASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_8G06820)	Riboflavin_Biosynth_HTPR	PANTHER

Orthologs

rib7 (SJAG_00491) Schizosaccharomyces japonicus
RIB7 (YBR153W) Saccharomyces cerevisiae

References / Literature

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.: Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.: Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323
PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.: Strachan J et al. J Cell Sci 2023 Dec 01;136(23)
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:20118936 - Schizosaccharomyces pombe genome-wide nucleosome mapping reveals positioning mechanisms distinct from those of Saccharomyces cerevisiae.: Lantermann AB et al. Nat Struct Mol Biol 2010 Feb;17(2):251-7
PMID:23695164 - Cross-species protein interactome mapping reveals species-specific wiring of stress response pathways.: Das J et al. Sci Signal 2013 May 21;6(276):ra38
PMID:21511999 - Comparative functional genomics of the fission yeasts.: Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).: Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.: Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.: Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.: Hayles J et al. Open Biol 2013 May 22;3(5):130053