protein coding gene - spo4 (SPBC21C3.18) - serine/threonine protein kinase (DDK family) Spo4

Gene summary

Standard name

spo4

Systematic ID

SPBC21C3.18

Product

serine/threonine protein kinase (DDK family) Spo4

Organism

Schizosaccharomyces pombe (fission yeast)

UniProt ID

Q9UQY9

ORFeome ID

40/40F07

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome II: 3827178..3828960 forward strand

Annotation

Protein features

Orthologs

• CDC7 (HGNC:1745) Homo sapiens
• spo4 (SJAG_00486) Schizosaccharomyces japonicus
• CDC7 (YDL017W) Saccharomyces cerevisiae

References / Literature

PMID:15893732 - Negative control contributes to an extensive program of meiotic splicing in fission yeast.

Averbeck N et al. Mol Cell 2005 May 13;18(4):491-8

PMID:36408920 - UniProt: the Universal Protein Knowledgebase in 2023.

UniProt Consortium Nucleic Acids Res 2023 Jan 06;51(D1):D523-D531

PMID:25452419 - Parallel profiling of fission yeast deletion mutants for proliferation and for lifespan during long-term quiescence.

Sideri T et al. G3 (Bethesda) 2014 Dec 01;5(1):145-55

PMID:1417417 - Electron microscopic examination of sporulation-deficient mutants of the fission yeast Schizosaccharomyces pombe.

Hirata A et al. Arch Microbiol 1992;158(4):249-55

PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.

Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7

PMID:31657618 - A Genome-Wide Screen for Wortmannin-Resistant Mutants in Schizosaccharomyces pombe: The Phosphorylation-Impaired Mutants Are Resistant to Signaling Defect.

Yılmazer M et al. DNA Cell Biol 2019 Dec;38(12):1427-1436

PMID:11739743 - Novel fission yeast Cdc7-Dbf4-like kinase complex required for the initiation and progression of meiotic second division.

Nakamura T et al. Mol Cell Biol 2002 Jan;22(1):309-20

PMID:28410370 - A systematic screen for morphological abnormalities during fission yeast sexual reproduction identifies a mechanism of actin aster formation for cell fusion.

Dudin O et al. PLoS Genet 2017 Apr;13(4):e1006721

PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.

Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105

PMID:22681890 - Hierarchical modularity and the evolution of genetic interactomes across species.

Ryan CJ et al. Mol Cell 2012 Jun 08;46(5):691-704

PMID:20970342 - Virtual breakdown of the nuclear envelope in fission yeast meiosis.

Asakawa H et al. Curr Biol 2010 Nov 09;20(21):1919-25

PMID:15821139 - Systematic deletion analysis of fission yeast protein kinases.

Bimbó A et al. Eukaryot Cell 2005 Apr;4(4):799-813

GO_REF:0000043 - Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping

PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.

Rodríguez-López M et al. Elife 2023 Oct 03;12

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:19264558 - Screening a genome-wide S. pombe deletion library identifies novel genes and pathways involved in genome stability maintenance.

Deshpande GP et al. DNA Repair (Amst) 2009 May 01;8(5):672-9

PMID:8203159 - Structural modification of spindle pole bodies during meiosis II is essential for the normal formation of ascospores in Schizosaccharomyces pombe: ultrastructural analysis of spo mutants.

Hirata A et al. Yeast 1994 Feb;10(2):173-83

PMID:29259000 - Genes Important for Schizosaccharomyces pombe Meiosis Identified Through a Functional Genomics Screen.

Blyth J et al. Genetics 2018 Feb;208(2):589-603

PMID:23370392 - A knockout screen for protein kinases required for the proper meiotic segregation of chromosomes in the fission yeast Schizosaccharomyces pombe.

Kovacikova I et al. Cell Cycle 2013 Feb 15;12(4):618-24

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

GO_REF:0000033 - Annotation inferences using phylogenetic trees

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:30647105 - Comparative Genomic Screen in Two Yeasts Reveals Conserved Pathways in the Response Network to Phenol Stress.

Alhoch B et al. G3 (Bethesda) 2019 Mar 07;9(3):639-650

PMID:34250083 - Barcode sequencing and a high-throughput assay for chronological lifespan uncover ageing-associated genes in fission yeast.

Romila CA et al. Microb Cell 2021 Jul 05;8(7):146-160

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:3442824 - Genetic mapping of eleven spo genes essential for ascospore formation in the fission yeast Schizosaccharomyces pombe.

Kishida M et al. Curr Genet 1986;10(6):443-7

PMID:34984977 - Functional profiling of long intergenic non-coding RNAs in fission yeast.

Rodriguez-Lopez M et al. Elife 2022 Jan 05;11

PMID:24727291 - A genome-wide screen for sporulation-defective mutants in Schizosaccharomyces pombe.

Ucisik-Akkaya E et al. G3 (Bethesda) 2014 Apr 11;4(6):1173-82