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protein coding gene - ucp3 (SPBC21D10.05c) - ArfGAP, GTPase activating protein for Arf6, Ucp3

Gene summary

Standard name
ucp3
Systematic ID
SPBC21D10.05c
Product
ArfGAP, GTPase activating protein for Arf6, Ucp3
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
soc2
UniProt ID
O74345
ORFeome ID
37/37B10
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome II: 2439023..2442631 forward strand

Annotation

GO biological process

GO:0051523 - cell growth mode switching, monopolar to bipolar

References:

GO cellular component

GO:0030479 - actin cortical patch

References:

GO:0051285 - cell cortex of cell tip

References:

GO:0032153 - cell division site

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GO:0071944 - cell periphery

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GO:0051286 - cell tip

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GO:0005829 - cytosol

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GO molecular function

GO:0005096 - GTPase activator activity

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GO:0031593 - polyubiquitin modification-dependent protein binding

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Modification

MOD:00046 - O-phospho-L-serine

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MOD:00047 - O-phospho-L-threonine

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MOD:01148 - ubiquitinylated lysine

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Protein features

PBO:0111815 - UBA domain protein

Qualitative gene expression

PomGeneEx:0000018 - protein level increased

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Quantitative gene expression

PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0000147 - abnormal NETO

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Genotypes:

FYPO:0005055 - binucleate multiseptate cell, septa grouped

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Genotypes:

FYPO:0002148 - inviable after spore germination, multiple cell divisions, abnormal morphology

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Genotypes:

FYPO:0002427 - inviable spore with abnormal shape

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Genotypes:

FYPO:0002061 - inviable vegetative cell population

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Genotypes:

FYPO:0001019 - monopolar actin cortical patch localization during vegetative growth

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Genotypes:

FYPO:0000276 - monopolar mitotic spindle

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Genotypes:

FYPO:0005960 - multipolar mitotic spindle

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Genotypes:

FYPO:0003702 - normal microtubule cytoskeleton morphology during vegetative growth

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Genotypes:

FYPO:0003858 - sensitive to etoposide

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Genotypes:

FYPO:0003305 - separate mitotic half spindles present

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Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011063 - conserved in fungi only

PBO:0006222 - predominantly single copy (one to one)

Protein features

IDNameInterPro nameDB name
PF01412ArfGapArfGAP_domPfam
cd08204ArfGapCDD
PS50030UBAUBAPROSITE profiles
PS50115ARFGAPArfGAP_domPROSITE profiles
SM00105ArfGapArfGAP_domSMART
SM00165UBAUBASMART
PR00405REVINTRACTNGArfGAP_domPRINTS
G3DSA:1.10.220.150:FF:000026CATH-FunFam
G3DSA:1.10.220.150ArfGAP_dom_sfCATH-Gene3D
G3DSA:1.10.8.10CATH-Gene3D
SSF46934UBA-like_sfSUPERFAMILY
SSF57863ARFGAP/RecO_Zfn_sfSUPERFAMILY
PTHR45705ARF_GTPase-activatingPANTHER
mobidb-lite-Disorderdisorder_predictionMobiDB-Disorder
mobidb-lite-Low-complexitydisorder_predictionMobiDB-Low-complexity

Orthologs

References / Literature

PMID:12672455 - UBA domain containing proteins in fission yeast.
Hartmann-Petersen R et al. Int J Biochem Cell Biol 2003 May;35(5):629-36
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.
Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:24945319 - CPF-associated phosphatase activity opposes condensin-mediated chromosome condensation.
Vanoosthuyse V et al. PLoS Genet 2014 Jun;10(6):e1004415
PMID:21107719 - Fission yeast ucp3 gene encodes a putative Arf6 GTPase-activating protein.
Fujita A et al. Mol Biol Rep 2011 Aug;38(6):3875-82
PMID:21340088 - Microarray-based target identification using drug hypersensitive fission yeast expressing ORFeome.
Arita Y et al. Mol Biosyst 2011 May;7(5):1463-72
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.
Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:21511999 - Comparative functional genomics of the fission yeasts.
Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PMID:31474649 - Identification of 15 New Bypassable Essential Genes of Fission Yeast.
Takeda A et al. Cell Struct Funct 2019 Sep 27;44(2):113-119
PMID:15797925 - The nuclear rim protein Amo1 is required for proper microtubule cytoskeleton organisation in fission yeast.
Pardo M et al. J Cell Sci 2005 Apr 15;118(Pt 8):1705-14
PMID:34958661 - Arf6 anchors Cdr2 nodes at the cell cortex to control cell size at division.
Opalko HE et al. J Cell Biol 2022 Feb 07;221(2)
PMID:28218250 - Chromatin remodeller Fun30 Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.
Lee J et al. Nat Commun 2017 Feb 20;8:14527
PMID:26412298 - A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.
Beckley JR et al. Mol Cell Proteomics 2015 Dec;14(12):3132-41
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:29996109 - Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe.
Swaffer MP et al. Cell Rep 2018 Jul 10;24(2):503-514
PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.
Strachan J et al. J Cell Sci 2023 Dec 01;136(23)