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protein coding gene - map4 (SPBC21D10.06c) - cell surface adhesion protein for conjugation Map4

Gene summary

Standard name
map4
Systematic ID
SPBC21D10.06c
Product
cell surface adhesion protein for conjugation Map4
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
O74346
ORFeome ID
47/47C09
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome II: 2434474..2438482 forward strand

Annotation

Comment

PBO:0114316 - repeat containing

PBO:0004058 - required in h+ but not in h-cells

References:

GO biological process

GO:0000752 - agglutination involved in conjugation with cellular fusion

References:

GO cellular component

GO:0070263 - external side of fungal-type cell wall

References:

GO:0043332 - mating projection tip

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GO molecular function

GO:0098631 - cell adhesion mediator activity

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Miscellaneous functional group

PBO:0000068 - cell surface glycoprotein

Modification

MOD:00693 - glycosylated residue

References:

MOD:00006 - N-glycosylated residue

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Protein features

PBO:0111907 - DIPSY domain

Protein sequence feature

SO:0000418 - signal_peptide

References:

Qualitative gene expression

PomGeneEx:0000018 - protein level increased

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PomGeneEx:0000011 - RNA level increased

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Quantitative gene expression

PBO:0011963 - RNA level

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Single locus phenotype

FYPO:0003709 - decreased agglutination

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Genotypes:

FYPO:0002521 - decreased frequency of conjugation with h- cells

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Genotypes:

FYPO:0000708 - decreased mating efficiency

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Genotypes:

FYPO:0000584 - decreased sporulation frequency

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Genotypes:

FYPO:0001871 - increased agglutination

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Genotypes:

FYPO:0001867 - increased shmoo formation

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Genotypes:

FYPO:0003708 - normal frequency of conjugation with h+ cells

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Genotypes:

FYPO:0000022 - shmoo with long tip

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Genotypes:

FYPO:0002060 - viable vegetative cell population

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Genotypes:

Taxonomic conservation

PBO:0011064 - conserved in fungi

PBO:0011063 - conserved in fungi only

PBO:0000055 - no apparent S. cerevisiae ortholog

Warnings

PBO:0109348 - 9 [SWVTETVTSGSVGFTTTIATPIGTTAGTVLVDIPTP-consensus] repeats reported (5 copies in reference)

References:

PBO:0000129 - sequence error in genomic data

References:

Protein features

IDNameInterPro nameDB name
PF11763DIPSYDIPSYPFAM
PS51825DIPSYDIPSYPROSITE_PROFILES
PTHR31492M CELL-TYPE AGGLUTINATION PROTEIN MAM3-RELATEDS_pombe_Mam3/Map4PANTHER
mobidb-lite-Disorderdisorder_predictionMOBIDB-Disorder
mobidb-lite-Low-complexitydisorder_predictionMOBIDB-Low-complexity
mobidb-lite-Polardisorder_predictionMOBIDB-Polar

Orthologs

References / Literature

PMID:16857197 - The fission yeast Map4 protein is a novel adhesin required for mating.
Sharifmoghadam MR et al. FEBS Lett 2006 Aug 07;580(18):4457-62
PMID:16537923 - Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.
Todd BL et al. Mol Cell Biol 2006 Apr;26(7):2817-31
PMID:17870620 - Molecular phylogenetics of ascomycotal adhesins--a novel family of putative cell-surface adhesive proteins in fission yeasts.
Linder T et al. Fungal Genet Biol 2008 Apr;45(4):485-97
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:31626996 - Multiplexed proteome profiling of carbon source perturbations in two yeast species with SL-SP3-TMT.
Paulo JA et al. J Proteomics 2020 Jan 06;210:103531
PMID:34967420 - Genetic screen for suppression of transcriptional interference reveals fission yeast 14-3-3 protein Rad24 as an antagonist of precocious Pol2 transcription termination.
Garg A et al. Nucleic Acids Res 2022 Jan 25;50(2):803-819
PMID:36408920 - UniProt: the Universal Protein Knowledgebase in 2023.
UniProt Consortium Nucleic Acids Res 2023 Jan 06;51(D1):D523-D531
PMID:39367033 - Quantitative proteomics and phosphoproteomics profiling of meiotic divisions in the fission yeast Schizosaccharomyces pombe.
Sivakova B et al. Sci Rep 2024 Oct 04;14(1):23105
PMID:27984744 - Survival in Quiescence Requires the Euchromatic Deployment of Clr4/SUV39H by Argonaute-Associated Small RNAs.
Joh RI et al. Mol Cell 2016 Dec 15;64(6):1088-1101
PMID:8668157 - Schizosaccharomyces pombe map1+ encodes a MADS-box-family protein required for cell-type-specific gene expression.
Yabana N et al. Mol Cell Biol 1996 Jul;16(7):3420-8
GO_REF:0000050 - Manual transfer of GO annotation data to genes by curator judgment of sequence model
PMID:20519959 - S. pombe genome deletion project: an update.
Spirek M et al. Cell Cycle 2010 Jun 15;9(12):2399-402
PMID:26896847 - Ensembl comparative genomics resources.
Herrero J et al. Database (Oxford) 2016;2016