protein coding gene - hob1 (SPBC21D10.12) - BAR adaptor protein, amphiphysin, Hob1

Gene summary

Standard name

hob1

Systematic ID

SPBC21D10.12

Product

BAR adaptor protein, amphiphysin, Hob1

Organism

Schizosaccharomyces pombe (fission yeast)

UniProt ID

O74352

ORFeome ID

23/23F06

Characterisation status

biological role published

Feature type

mRNA gene

Genomic location

chromosome II: 2420263..2422276 reverse strand

Annotation

Protein features

Orthologs

• BIN1 (HGNC:1052) Homo sapiens
• BIN2 (HGNC:1053) Homo sapiens
• AMPH (HGNC:471) Homo sapiens
• hob1 (SJAG_00185) Schizosaccharomyces japonicus
• RVS167 (YDR388W) Saccharomyces cerevisiae

References / Literature

PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs

PMID:25040903 - Eng2 is a component of a dynamic protein complex required for endocytic uptake in fission yeast.

Encinar del Dedo J et al. Traffic 2014 Oct;15(10):1122-42

PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.

Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963

PMID:22119525 - SIN-inhibitory phosphatase complex promotes Cdc11p dephosphorylation and propagates SIN asymmetry in fission yeast.

Singh NS et al. Curr Biol 2011 Dec 06;21(23):1968-78

PMID:22806344 - Genome-wide screen reveals novel mechanisms for regulating cobalt uptake and detoxification in fission yeast.

Ryuko S et al. Mol Genet Genomics 2012 Aug;287(8):651-62

PMID:21712547 - Mitotic substrates of the kinase aurora with roles in chromatin regulation identified through quantitative phosphoproteomics of fission yeast.

Koch A et al. Sci Signal 2011 Jun 28;4(179):rs6

PMID:26412298 - A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.

Beckley JR et al. Mol Cell Proteomics 2015 Dec;14(12):3132-41

PMID:17671430 - Bin1 interacts with and restrains the DNA end-binding protein complex Ku.

Ramalingam A et al. Cell Cycle 2007 Aug 01;6(15):1914-8

PMID:29996109 - Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe.

Swaffer MP et al. Cell Rep 2018 Jul 10;24(2):503-514

PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.

Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623

PMID:33260998 - High-Throughput Flow Cytometry Combined with Genetic Analysis Brings New Insights into the Understanding of Chromatin Regulation of Cellular Quiescence.

Zahedi Y et al. Int J Mol Sci 2020 Nov 27;21(23)

PMID:42691030 - The G-patch protein Cwf28 interacts with the RNA helicase Cdc28 in catalytically active spliceosomes in Schizosaccharomyces pombe.

Karika LO et al. PLoS One 2026;21(9):e0357276

PMID:15615784 - Nak1 interacts with Hob1 and Wsp1 to regulate cell growth and polarity in Schizosaccharomyces pombe.

Huang TY et al. J Cell Sci 2005 Jan 01;118(Pt 1):199-210

PMID:12569356 - hob1+, the fission yeast homolog of Bin1, is dispensable for endocytosis or actin organization, but required for the response to starvation or genotoxic stress.

Routhier EL et al. Oncogene 2003 Feb 06;22(5):637-48

PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.

Marguerat S et al. Cell 2012 Oct 26;151(3):671-83

PMID:25720772 - Quantitative phosphoproteomics reveals pathways for coordination of cell growth and division by the conserved fission yeast kinase pom1.

Kettenbach AN et al. Mol Cell Proteomics 2015 May;14(5):1275-87

PMID:30726745 - Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex.

Tay YD et al. Cell Rep 2019 Feb 05;26(6):1654-1667.e7

PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.

Hayles J et al. Open Biol 2013 May 22;3(5):130053

PMID:33823663 - A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.

Halova L et al. Open Biol 2021 Apr;11(4):200405

PMID:23399914 - Increased expression of BIN1 mediates Alzheimer genetic risk by modulating tau pathology.

Chapuis J et al. Mol Psychiatry 2013 Nov;18(11):1225-34

GO_REF:0000033 - Annotation inferences using phylogenetic trees

PMID:40594858 - Dbl2 interacts with helicases and an endonuclease to maintain the integrity of repetitive regions.

Bakosova A et al. Sci Rep 2025 Jul 01;15(1):21895

PMID:27984744 - Survival in Quiescence Requires the Euchromatic Deployment of Clr4/SUV39H by Argonaute-Associated Small RNAs.

Joh RI et al. Mol Cell 2016 Dec 15;64(6):1088-1101

PMID:21511999 - Comparative functional genomics of the fission yeasts.

Rhind N et al. Science 2011 May 20;332(6032):930-6

PMID:28228545 - Ablation of RNA interference and retrotransposons accompany acquisition and evolution of transposases to heterochromatin protein CENPB.

Upadhyay U et al. Mol Biol Cell 2017 Apr 15;28(8):1132-1146

PMID:21504829 - Yeast SREBP cleavage activation requires the Golgi Dsc E3 ligase complex.

Stewart EV et al. Mol Cell 2011 Apr 22;42(2):160-71

GO_REF:0000050 - Manual transfer of GO annotation data to genes by curator judgment of sequence model

PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.

Rodríguez-López M et al. Elife 2023 Oct 03;12

PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36

PMID:28410370 - A systematic screen for morphological abnormalities during fission yeast sexual reproduction identifies a mechanism of actin aster formation for cell fusion.

Dudin O et al. PLoS Genet 2017 Apr;13(4):e1006721

PMID:37970674 - SUMOylation regulates Lem2 function in centromere clustering and silencing.

Strachan J et al. J Cell Sci 2023 Dec 01;136(23)

PMID:17611416 - Bin1 homolog hob1 supports a Rad6-Set1 pathway of transcriptional repression in fission yeast.

Ramalingam A et al. Cell Cycle 2007 Jul 01;6(13):1655-62

PMID:26670050 - Regulation of mRNA Levels by Decay-Promoting Introns that Recruit the Exosome Specificity Factor Mmi1.

Kilchert C et al. Cell Rep 2015 Dec 22;13(11):2504-2515

PMID:18257517 - Phosphoproteome analysis of fission yeast.

Wilson-Grady JT et al. J Proteome Res 2008 Mar;7(3):1088-97