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protein coding gene - SPBC21H7.03c - multiple inositol polyphosphate phosphatase

Gene summary

Systematic ID
SPBC21H7.03c
Product
multiple inositol polyphosphate phosphatase
Organism
Schizosaccharomyces pombe (fission yeast)
UniProt ID
O60172
ORFeome ID
21/21E09
Characterisation status
biological role inferred
Feature type
mRNA gene
Genomic location
chromosome II: 2256557..2258340 reverse strand

Annotation

PBO:0002267 - 3.1.3.2

Disease association

MONDO:0030438 - pontocerebellar hypoplasia, type 16

References:

MONDO:0008566 - thyroid cancer, nonmedullary, 2

References:

GO biological process

GO:0043647 - inositol phosphate metabolic process

References:

GO:0046434 - organophosphate catabolic process

References:

GO cellular component

GO:0005576 - extracellular region

References:

GO molecular function

GO:0003993 - acid phosphatase activity

References:

GO:0052745 - inositol phosphate phosphatase activity

References:

Modification

MOD:00006 - N-glycosylated residue

References:

Protein sequence feature

SO:0000418 - signal_peptide

References:

Qualitative gene expression

PomGeneEx:0000019 - protein level decreased

References:

PomGeneEx:0000027 - ribosomal density decreased

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PomGeneEx:0000012 - RNA level decreased

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PomGeneEx:0000011 - RNA level increased

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Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0001355 - decreased vegetative cell population growth

References:

Genotypes:

FYPO:0000763 - resistance to cadmium

References:

Genotypes:

FYPO:0009038 - resistance to egtazic acid

References:

Genotypes:

FYPO:0001583 - resistance to lithium

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Genotypes:

FYPO:0009083 - resistance to lithium chloride and methyl methanesulfonate

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Genotypes:

FYPO:0009087 - resistance to magnesium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0009043 - resistance to potassium chloride and sodium dodecyl sulfate

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Genotypes:

FYPO:0005193 - resistance to torin1

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Genotypes:

FYPO:0000830 - resistance to vanadate

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Genotypes:

FYPO:0009086 - sensitive to lithium chloride and sodium dodecyl sulfate

References:

Genotypes:

FYPO:0009082 - sensitive to potassium chloride and methyl methanesulfonate

References:

Genotypes:

FYPO:0001457 - sensitive to tunicamycin

References:

Genotypes:

FYPO:0002060 - viable vegetative cell population

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Genotypes:

FYPO:0002177 - viable vegetative cell with normal cell morphology

References:

Genotypes:

Taxonomic conservation

PBO:0011065 - conserved in eukaryotes

PBO:0011071 - conserved in eukaryotes only

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

Protein features

IDNameInterPro nameDB name
PF00328His_Phos_2His_Pase_clade-2PFAM
cd07061HP_HAP_likeHis_Pase_clade-2CDD
PS00778HIS_ACID_PHOSPHAT_2Acid_Pase_ASPROSITE_PATTERNS
PS00616HIS_ACID_PHOSPHAT_1Acid_Pase_ASPROSITE_PATTERNS
G3DSA:3.40.50.1240:FF:000119FUNFAM
SSF53254Phosphoglycerate mutase-likeHis_PPase_superfamSUPERFAMILY
G3DSA:3.40.50.1240His_PPase_superfamGENE3D
PTHR20963MULTIPLE INOSITOL POLYPHOSPHATE PHOSPHATASE-RELATEDPANTHER
PIRSF000894Acid_PtaseHistidine_acid_Pase_eukPIRSF

Orthologs

References / Literature

PMID:16278451 - Activation of AP-1-dependent transcription by a truncated translation initiation factor.
Jenkins CC et al. Eukaryot Cell 2005 Nov;4(11):1840-50
PMID:22633491 - Mapping N-glycosylation sites across seven evolutionarily distant species reveals a divergent substrate proteome despite a common core machinery.
Zielinska DF et al. Mol Cell 2012 May 25;46(4):542-8
PMID:36408920 - UniProt: the Universal Protein Knowledgebase in 2023.
UniProt Consortium Nucleic Acids Res 2023 Jan 06;51(D1):D523-D531
GO_REF:0000024 - Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:33313903 - Ribosome profiling reveals ribosome stalling on tryptophan codons and ribosome queuing upon oxidative stress in fission yeast.
Rubio A et al. Nucleic Acids Res 2021 Jan 11;49(1):383-399
GO_REF:0000033 - Annotation inferences using phylogenetic trees
GO_REF:0000051 - S. pombe keyword mapping
PMID:36794724 - Cellular responses to long-term phosphate starvation of fission yeast: Maf1 determines fate choice between quiescence and death associated with aberrant tRNA biogenesis.
Garg A et al. Nucleic Acids Res 2023 Apr 24;51(7):3094-3115
PMID:39705284 - Proteomic and phosphoproteomic analyses reveal that TORC1 is reactivated by pheromone signaling during sexual reproduction in fission yeast.
Bérard M et al. PLoS Biol 2024 Dec 20;22(12):e3002963
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:16537923 - Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.
Todd BL et al. Mol Cell Biol 2006 Apr;26(7):2817-31
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:26896847 - Ensembl comparative genomics resources.
Herrero J et al. Database (Oxford) 2016;2016
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.
Hayles J et al. Open Biol 2013 May 22;3(5):130053
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:37787768 - Broad functional profiling of fission yeast proteins using phenomics and machine learning.
Rodríguez-López M et al. Elife 2023 Oct 03;12