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protein coding gene - mat1-Mc (SPBC23G7.09) - M-specific trancription factor Mc

Gene summary

Standard name
mat1-Mc
Systematic ID
SPBC23G7.09
Product
M-specific trancription factor Mc
Organism
Schizosaccharomyces pombe (fission yeast)
Synonyms
matMc, mat1Mc, matmc_1
UniProt ID
P0CY17
ORFeome ID
05/05E10
Characterisation status
biological role published
Feature type
mRNA gene
Genomic location
chromosome II: 2114482..2115027 forward strand

Annotation

GO biological process

GO:0007531 - mating type determination

References:

GO:0031139 - positive regulation of conjugation with cellular fusion

References:

GO:0045944 - positive regulation of transcription by RNA polymerase II

References:

GO cellular component

GO:0000785 - chromatin

References:

GO:0090575 - RNA polymerase II transcription regulator complex

References:

GO molecular function

GO:0001228 - DNA-binding transcription activator activity, RNA polymerase II-specific

References:

GO:0005515 - protein binding

References:

GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding

References:

GO:0044377 - RNA polymerase II cis-regulatory region sequence-specific DNA binding, bending

References:

GO:0044374 - sequence-specific DNA binding, bending

References:

GO:0003713 - transcription coactivator activity

References:

Multi-locus phenotype

FYPO:0005118 - decreased transcription during nitrogen starvation

References:

Genotypes:

FYPO:0001355 - decreased vegetative cell population growth

References:

Genotypes:

FYPO:0001890 - increased RNA level

References:

Genotypes:

FYPO:0001886 - meiotic cell cycle entry and sporulation in haploid

References:

Genotypes:

Protein features

PBO:0111771 - HMG box

PBO:0111926 - mating-type m-specific polypeptide matMc

Qualitative gene expression

PomGeneEx:0000011 - RNA level increased

References:

PomGeneEx:0000014 - RNA present

References:

Quantitative gene expression

PBO:0011963 - RNA level

References:

Single locus phenotype

FYPO:0000569 - abolished shmoo formation

References:

Genotypes:

FYPO:0000046 - decreased cell population growth

References:

Genotypes:

FYPO:0001324 - decreased protein level during vegetative growth

References:

Genotypes:

FYPO:0003573 - decreased protein localization to heterochromatin at silent mating-type cassette

References:

Genotypes:

FYPO:0003847 - h- specific sterility

References:

Genotypes:

FYPO:0001996 - RNA absent from cell during nitrogen starvation

References:

Genotypes:

FYPO:0000280 - sterile

References:

Genotypes:

FYPO:0002060 - viable vegetative cell population

References:

Genotypes:

Taxonomic conservation

PBO:0011064 - conserved in fungi

PBO:0011063 - conserved in fungi only

PBO:0000055 - no apparent S. cerevisiae ortholog

Protein features

IDNameInterPro nameDB name
PF00505HMG_boxHMG_box_domPfam
cd01389HMG-box_ROX1-likeCDD
PS50118HMG_BOX_2HMG_box_domPROSITE profiles
SM00398HMGHMG_box_domSMART
G3DSA:1.10.30.10:FF:000041CATH-FunFam
G3DSA:1.10.30.10HMG_box_dom_sfCATH-Gene3D
SSF47095HMG_box_dom_sfSUPERFAMILY
PTHR10270SRY-related_HMG-box_TF-likePANTHER

Orthologs

References / Literature

PMID:20519959 - S. pombe genome deletion project: an update.
Spirek M et al. Cell Cycle 2010 Jun 15;9(12):2399-402
PMID:23163955 - Analysis of stress-induced duplex destabilization (SIDD) properties of replication origins, genes and intergenes in the fission yeast, Schizosaccharomyces pombe.
Yadav MP et al. BMC Res Notes 2012 Nov 19;5:643
PMID:9233811 - Cell differentiation by interaction of two HMG-box proteins: Mat1-Mc activates M cell-specific genes in S.pombe by recruiting the ubiquitous transcription factor Ste11 to weak binding sites.
Kjaerulff S et al. EMBO J 1997 Jul 01;16(13):4021-33
PMID:2900761 - Four mating-type genes control sexual differentiation in the fission yeast.
Kelly M et al. EMBO J 1988 May;7(5):1537-47
PMID:10867006 - Sequence-specific high mobility group box factors recognize 10-12-base pair minor groove motifs.
van Beest M et al. J Biol Chem 2000 Sep 01;275(35):27266-73
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.
Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:2328719 - The pat1 protein kinase controls transcription of the mating-type genes in fission yeast.
Nielsen O et al. EMBO J 1990 May;9(5):1401-6
PMID:35924983 - Genetic-interaction screens uncover novel biological roles and regulators of transcription factors in fission yeast.
Chatfield-Reed K et al. G3 (Bethesda) 2022 Aug 25;12(9)
GO_REF:0000051 - S. pombe keyword mapping
PMID:22042869 - A homolog of male sex-determining factor SRY cooperates with a transposon-derived CENP-B protein to control sex-specific directed recombination.
Matsuda E et al. Proc Natl Acad Sci U S A 2011 Nov 15;108(46):18754-9
PMID:23695302 - Functional characterization of fission yeast transcription factors by overexpression analysis.
Vachon L et al. Genetics 2013 Aug;194(4):873-84
PMID:26771498 - A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.
Vo TV et al. Cell 2016 Jan 14;164(1-2):310-323
PMID:2300054 - Schizosaccharomyces pombe ras1 and byr1 are functionally related genes of the ste family that affect starvation-induced transcription of mating-type genes.
Nadin-Davis SA et al. Mol Cell Biol 1990 Feb;10(2):549-60
PMID:26896847 - Ensembl comparative genomics resources.
Herrero J et al. Database (Oxford) 2016;2016
PMID:34460892 - Transcriptome sequencing and screening of genes related to glucose availability in Schizosaccharomyces pombe by RNA-seq analysis.
Tarhan Ç et al. Genet Mol Biol 2021;44(3):e20200245
PMID:7651414 - Two-step activation of meiosis by the mat1 locus in Schizosaccharomyces pombe.
Willer M et al. Mol Cell Biol 1995 Sep;15(9):4964-70
PMID:29610759 - Molecular signature of the imprintosome complex at the mating-type locus in fission yeast.
Raimondi C et al. Microb Cell 2018 Jan 16;5(4):169-183
PMID:7900424 - Assessment of pheromone production and response in fission yeast by a halo test of induced sporulation.
Egel R et al. Yeast 1994 Oct;10(10):1347-54
PMID:1657709 - Schizosaccharomyces pombe ste11+ encodes a transcription factor with an HMG motif that is a critical regulator of sexual development.
Sugimoto A et al. Genes Dev 1991 Nov;5(11):1990-9
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.
Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:8227043 - The Schizosaccharomyces pombe mating-type gene mat-Mc encodes a sequence-specific DNA-binding high mobility group box protein.
Dooijes D et al. J Biol Chem 1993 Nov 25;268(33):24813-7
PMID:8196631 - Analysis of the structural genes encoding M-factor in the fission yeast Schizosaccharomyces pombe: identification of a third gene, mfm3.
Kjaerulff S et al. Mol Cell Biol 1994 Jun;14(6):3895-905