protein coding gene - SPBC24C6.03 - mitochondrial proline-tRNA ligase

Gene summary

Systematic ID: SPBC24C6.03
Product: mitochondrial proline-tRNA ligase
Organism: Schizosaccharomyces pombe (fission yeast)
UniProt ID: O74765
ORFeome ID: 20/20D12
Characterisation status: biological role inferred
Feature type: mRNA gene
Genomic location: chromosome II: 2322938..2324873 forward strand

Annotation

PBO:0004004 - 6.1.1.15

Disease association

MONDO:0032752 - developmental and epileptic encephalopathy, 75

References:

PB_REF:0000006

MONDO:0018614 - undetermined early-onset epileptic encephalopathy

References:

PB_REF:0000003

GO biological process

GO:0070157 - mitochondrial prolyl-tRNA aminoacylation

References:

GO_REF:0000033

GO cellular component

GO:0005759 - mitochondrial matrix

References:

GO_REF:0000111

GO:0005739 - mitochondrion

References:

PMID:16823372

GO molecular function

GO:0005524 - ATP binding

References:

GO_REF:0000002

GO:0004827 - proline-tRNA ligase activity

References:

GO_REF:0000033

Protein sequence feature

SO:0001808 - mitochondrial_targeting_signal

References:

PMID:36408920

Qualitative gene expression

PomGeneEx:0000012 - RNA level decreased

References:

PMID:16537923

Quantitative gene expression

PBO:0006310 - protein level

References:

PBO:0011963 - RNA level

References:

PMID:23101633

Single locus phenotype

FYPO:0002111 - inviable tapered vegetative cell

References:

PMID:23697806

Genotypes:

SPBC24C6.03delta

FYPO:0002061 - inviable vegetative cell population

References:

Genotypes:

SPBC24C6.03delta

Taxonomic conservation

PBO:0011067 - conserved in bacteria

PBO:0011065 - conserved in eukaryotes

PBO:0011064 - conserved in fungi

PBO:0011069 - conserved in metazoa

PBO:0011070 - conserved in vertebrates

PBO:0006222 - predominantly single copy (one to one)

Protein features

ID	Name	InterPro name	DB name
PF03129	HGTP_anticodon	Anticodon-bd	PFAM
PF00587	tRNA-synt_2b	aa-tRNA-synt_IIb	PFAM
cd00779	ProRS_core_prok	ProRS_core_prok	CDD
cd00861	ProRS_anticodon_short	ProRS_anticodon_short	CDD
PS50862	AA_TRNA_LIGASE_II	aa-tRNA-synth_II	PROSITE_PROFILES
PR01046	TRNASYNTHPRO	Pro-tRNA-ligase_IIa	PRINTS
G3DSA:3.30.930.10:FF:000042			FUNFAM
G3DSA:3.40.50.800:FF:000032			FUNFAM
SSF52954	Class II aaRS ABD-related		SUPERFAMILY
SSF55681	Class II aaRS and biotin synthetases	aa-tRNA-synth_II/BPL/LPL	SUPERFAMILY
G3DSA:3.40.50.800		Anticodon-bd_dom_sf	GENE3D
G3DSA:3.30.930.10	Bira Bifunctional Protein; Domain 2	aa-tRNA-synth_II/BPL/LPL	GENE3D
PTHR42753	MITOCHONDRIAL RIBOSOME PROTEIN L39/PROLYL-TRNA LIGASE FAMILY MEMBER	Pro-tRNA_synthetase	PANTHER

Orthologs

PARS2 (HGNC:30563) Homo sapiens
SJAG_02236 Schizosaccharomyces japonicus
AIM10 (YER087W) Saccharomyces cerevisiae

References / Literature

GO_REF:0000111 - Gene Ontology annotations Inferred by Curator (IC) using at least one Inferred by Sequence Similarity (ISS) annotation to support the inference
PMID:24763107 - Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).: Carpy A et al. Mol Cell Proteomics 2014 Aug;13(8):1925-36
PMID:16537923 - Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.: Todd BL et al. Mol Cell Biol 2006 Apr;26(7):2817-31
PB_REF:0000006 - Disease associations from Monarch via human-pombe orthologs
PMID:36408920 - UniProt: the Universal Protein Knowledgebase in 2023.: UniProt Consortium Nucleic Acids Res 2023 Jan 06;51(D1):D523-D531
GO_REF:0000033 - Annotation inferences using phylogenetic trees
PMID:20473289 - Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe.: Kim DU et al. Nat Biotechnol 2010 Jun;28(6):617-623
PMID:23101633 - Quantitative analysis of fission yeast transcriptomes and proteomes in proliferating and quiescent cells.: Marguerat S et al. Cell 2012 Oct 26;151(3):671-83
PMID:23697806 - A genome-wide resource of cell cycle and cell shape genes of fission yeast.: Hayles J et al. Open Biol 2013 May 22;3(5):130053
PB_REF:0000003 - Disease Association Curation
PMID:16823372 - ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.: Matsuyama A et al. Nat Biotechnol 2006 Jul;24(7):841-7
GO_REF:0000002 - Comments
PMID:21511999 - Comparative functional genomics of the fission yeasts.: Rhind N et al. Science 2011 May 20;332(6032):930-6
PMID:31474649 - Identification of 15 New Bypassable Essential Genes of Fission Yeast.: Takeda A et al. Cell Struct Funct 2019 Sep 27;44(2):113-119